Trait: left ventricular ejection fraction measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0008373
Description quantification of the volumetric fraction of blood pumped out of the left ventricle
Trait category
Cardiovascular measurement
Mapped term PMID:28763429

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001412
(GBE_INI22420)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
LV ejection fraction left ventricular ejection fraction measurement 266
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001412/ScoringFiles/PGS001412.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005315 PGS001412
(GBE_INI22420)
PSS004986|
African Ancestry|
192 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: LV ejection fraction : 0.07902 [0.06643, 0.0916]
Incremental R2 (full-covars): 0.0065
PGS R2 (no covariates): 0.00921 [0.00459, 0.01383]
age, sex, UKB array type, Genotype PCs
PPM005316 PGS001412
(GBE_INI22420)
PSS004987|
East Asian Ancestry|
110 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: LV ejection fraction : 0.21638 [0.18183, 0.25092]
Incremental R2 (full-covars): 0.00243
PGS R2 (no covariates): 0.0051 [-0.00163, 0.01183]
age, sex, UKB array type, Genotype PCs
PPM005317 PGS001412
(GBE_INI22420)
PSS004988|
European Ancestry|
1,708 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: LV ejection fraction : 0.07182 [0.06564, 0.07799]
Incremental R2 (full-covars): 0.0014
PGS R2 (no covariates): 0.00189 [0.00081, 0.00297]
age, sex, UKB array type, Genotype PCs
PPM005318 PGS001412
(GBE_INI22420)
PSS004989|
South Asian Ancestry|
319 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: LV ejection fraction : 0.06719 [0.05648, 0.07789]
Incremental R2 (full-covars): 0.00348
PGS R2 (no covariates): 0.00252 [0.00031, 0.00474]
age, sex, UKB array type, Genotype PCs
PPM005319 PGS001412
(GBE_INI22420)
PSS004990|
European Ancestry|
5,528 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: LV ejection fraction : 0.04862 [0.04545, 0.05179]
Incremental R2 (full-covars): 0.00384
PGS R2 (no covariates): 0.00375 [0.00283, 0.00468]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004988 1,708 individuals European non-white British ancestry UKB
PSS004989 319 individuals South Asian UKB
PSS004990 5,528 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS004986 192 individuals African unspecified UKB
PSS004987 110 individuals East Asian UKB