Trait: executive function measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009332
Description Quantification of executive function in an individual, for example using the Behavioural Rating Inventory of Executive Function (BRIEF). Tests of executive function may be performed as part of a more comprehensive assessment to diagnose neurological and psychiatric disorders.
Trait category
Other measurement
Mapped term PMID:29769613

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
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Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS003723
(cEF)
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Common executive function executive function measurement 6,683,248
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003723/ScoringFiles/PGS003723.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018417 PGS003723
(cEF)
 PSS010959|
European Ancestry|
916 individuals
 PGP000465 |
Hatoum AS et al. Biol Psychiatry (2022)
 Reported Trait: Common Executive Function β: 0.171 — R²: 0.136 PCs1-10, genotyping batch, IQ PGS cEF and IQ were genetically correlated (0.61) so were used as covariates in the PGS prediction model.

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010959 — — 916 individuals — European — COL_Twin —