Trait: paroxysmal tachycardia

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009493
Description A form of tachycardia which begins and ends in an acute (or paroxysmal) manner.
Trait category
Other trait
Synonym Bouveret-Hoffmann syndrome

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019190
(TPMI_427.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 70
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019190/ScoringFiles/PGS019190.txt.gz
PGS019191
(TPMI_427.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 215,523
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019191/ScoringFiles/PGS019191.txt.gz
PGS019192
(TPMI_427.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 593,905
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019192/ScoringFiles/PGS019192.txt.gz
PGS019193
(TPMI_427.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019193/ScoringFiles/PGS019193.txt.gz
PGS019194
(TPMI_427.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Paroxysmal tachycardia unspecified paroxysmal tachycardia 1,005,558
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019194/ScoringFiles/PGS019194.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037372 PGS019190
(TPMI_427.1_Lassosum2)
 PSS013088|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60796 R²: 0.00608 sex, age, array, PCs 1-10 —
PPM037373 PGS019191
(TPMI_427.1_LDpred2)
 PSS013087|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60822 R²: 0.00609 sex, age, array, PCs 1-10 —
PPM037374 PGS019192
(TPMI_427.1_MegaPRS)
 PSS013089|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.6094 R²: 0.00622 sex, age, array, PCs 1-10 —
PPM037375 PGS019193
(TPMI_427.1_PRS-CS)
 PSS013090|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60689 R²: 0.00598 sex, age, array, PCs 1-10 —
PPM037376 PGS019194
(TPMI_427.1_SBayesR)
 PSS013091|
East Asian Ancestry|
17,754 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Paroxysmal tachycardia unspecified — AUROC: 0.60875 R²: 0.00611 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013087 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013088 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013089 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013090 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013091 427.0, 427.1, 427.2,I47, I49.2 —
[
  • 237 cases
  • , 17,517 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —