Trait: knee injury

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009507
Description Injury to a knee.
Trait category
Other trait
Mapped terms 4 mapped terms
  • ICD10:M23
  • ICD10:S83
  • MedDRA:10049032
  • NCIt:C34753

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001027
(GBE_HC1228)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Internal derangement of knee (time-to-event) knee injury 118
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001027/ScoringFiles/PGS001027.txt.gz
PGS004482
(disease.M23.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 M23 (Internal derangement of knee) knee injury 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004482/ScoringFiles/PGS004482.txt.gz
PGS004552
(meta.M23.score)
 PGP000561 |
Jung H et al. Commun Biol (2024)
 M23 (Internal derangement of knee) knee injury 1,059,939
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004552/ScoringFiles/PGS004552.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007898 PGS001027
(GBE_HC1228)
 PSS004218|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE internal derangement of knee — AUROC: 0.56341 [0.52693, 0.59989] R²: 0.00585
Incremental AUROC (full-covars): 0.00115
PGS R2 (no covariates): 3e-05
PGS AUROC (no covariates): 0.50405 [0.46861, 0.5395]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007899 PGS001027
(GBE_HC1228)
 PSS004219|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE internal derangement of knee — AUROC: 0.64127 [0.55335, 0.72919] R²: 0.03262
Incremental AUROC (full-covars): -0.00558
PGS R2 (no covariates): 0.00257
PGS AUROC (no covariates): 0.46969 [0.36107, 0.57831]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007900 PGS001027
(GBE_HC1228)
 PSS004220|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE internal derangement of knee — AUROC: 0.56835 [0.55076, 0.58594] R²: 0.00846
Incremental AUROC (full-covars): 0.00602
PGS R2 (no covariates): 0.00183
PGS AUROC (no covariates): 0.53474 [0.51634, 0.55313]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007901 PGS001027
(GBE_HC1228)
 PSS004221|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE internal derangement of knee — AUROC: 0.58042 [0.55004, 0.61081] R²: 0.00979
Incremental AUROC (full-covars): 0.0024
PGS R2 (no covariates): 0.00073
PGS AUROC (no covariates): 0.52142 [0.48981, 0.55302]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007902 PGS001027
(GBE_HC1228)
 PSS004222|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: TTE internal derangement of knee — AUROC: 0.57119 [0.56069, 0.58168] R²: 0.00868
Incremental AUROC (full-covars): 0.00602
PGS R2 (no covariates): 0.00125
PGS AUROC (no covariates): 0.52611 [0.51534, 0.53687]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM020597 PGS004482
(disease.M23.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: M23 (Internal derangement of knee) OR: 1.16467 — — — —
PPM020667 PGS004552
(meta.M23.score)
 PSS011364|
European Ancestry|
56,192 individuals
 PGP000561 |
Jung H et al. Commun Biol (2024)
 Reported Trait: M23 (Internal derangement of knee) OR: 1.21389 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004220 — —
[
  • 1,002 cases
  • , 23,903 controls
]
 — European non-white British ancestry UKB —
PSS004221 — —
[
  • 348 cases
  • , 7,483 controls
]
 — South Asian — UKB —
PSS004222 — —
[
  • 2,893 cases
  • , 64,532 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)
PSS011364 — — 56,192 individuals — European — UKB —
PSS004218 — —
[
  • 253 cases
  • , 6,244 controls
]
 — African unspecified — UKB —
PSS004219 — —
[
  • 36 cases
  • , 1,668 controls
]
 — East Asian — UKB —