Trait: Chronic Obstructive Asthma

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009759
Description Chronic airway obstruction caused by asthma.
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019285
(TPMI_495.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 27,488
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019285/ScoringFiles/PGS019285.txt.gz
PGS019286
(TPMI_495.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 939,808
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019286/ScoringFiles/PGS019286.txt.gz
PGS019287
(TPMI_495.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 619,851
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019287/ScoringFiles/PGS019287.txt.gz
PGS019288
(TPMI_495.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 983,770
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019288/ScoringFiles/PGS019288.txt.gz
PGS019289
(TPMI_495.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic obstructive asthma Chronic Obstructive Asthma 1,041,003
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019289/ScoringFiles/PGS019289.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037467 PGS019285
(TPMI_495.1_Lassosum2)
 PSS013188|
East Asian Ancestry|
17,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic obstructive asthma — AUROC: 0.68678 R²: 0.03596 sex, age, array, PCs 1-10 —
PPM037468 PGS019286
(TPMI_495.1_LDpred2)
 PSS013187|
East Asian Ancestry|
17,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic obstructive asthma — AUROC: 0.68669 R²: 0.0359 sex, age, array, PCs 1-10 —
PPM037469 PGS019287
(TPMI_495.1_MegaPRS)
 PSS013189|
East Asian Ancestry|
17,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic obstructive asthma — AUROC: 0.68653 R²: 0.03591 sex, age, array, PCs 1-10 —
PPM037470 PGS019288
(TPMI_495.1_PRS-CS)
 PSS013190|
East Asian Ancestry|
17,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic obstructive asthma — AUROC: 0.68698 R²: 0.03593 sex, age, array, PCs 1-10 —
PPM037471 PGS019289
(TPMI_495.1_SBayesR)
 PSS013191|
East Asian Ancestry|
17,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic obstructive asthma — AUROC: 0.68745 R²: 0.03598 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013187 493.2, —
[
  • 532 cases
  • , 17,110 controls
]
,
46.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013188 493.2, —
[
  • 532 cases
  • , 17,110 controls
]
,
46.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013189 493.2, —
[
  • 532 cases
  • , 17,110 controls
]
,
46.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013190 493.2, —
[
  • 532 cases
  • , 17,110 controls
]
,
46.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013191 493.2, —
[
  • 532 cases
  • , 17,110 controls
]
,
46.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —