Trait: stage 5 chronic kidney disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009909
Description A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine.
Trait category
Other trait
Synonyms 5 synonyms
  • End stage renal disease
  • End stage renal failure
  • End-stage renal failure
  • chronic renal failure
  • end-stage renal disease

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019437
(TPMI_585.32_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 289,757
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019437/ScoringFiles/PGS019437.txt.gz
PGS019438
(TPMI_585.32_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 939,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019438/ScoringFiles/PGS019438.txt.gz
PGS019439
(TPMI_585.32_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 594,737
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019439/ScoringFiles/PGS019439.txt.gz
PGS019440
(TPMI_585.32_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 983,786
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019440/ScoringFiles/PGS019440.txt.gz
PGS019441
(TPMI_585.32_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 End stage renal disease stage 5 chronic kidney disease 1,019,216
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019441/ScoringFiles/PGS019441.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037619 PGS019437
(TPMI_585.32_Lassosum2)
 PSS013330|
East Asian Ancestry|
17,095 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: End stage renal disease — AUROC: 0.656 R²: 0.03379 sex, age, array, PCs 1-10 —
PPM037620 PGS019438
(TPMI_585.32_LDpred2)
 PSS013329|
East Asian Ancestry|
17,095 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: End stage renal disease — AUROC: 0.65353 R²: 0.03364 sex, age, array, PCs 1-10 —
PPM037621 PGS019439
(TPMI_585.32_MegaPRS)
 PSS013331|
East Asian Ancestry|
17,095 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: End stage renal disease — AUROC: 0.64983 R²: 0.03151 sex, age, array, PCs 1-10 —
PPM037622 PGS019440
(TPMI_585.32_PRS-CS)
 PSS013332|
East Asian Ancestry|
17,095 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: End stage renal disease — AUROC: 0.65158 R²: 0.03369 sex, age, array, PCs 1-10 —
PPM037623 PGS019441
(TPMI_585.32_SBayesR)
 PSS013333|
East Asian Ancestry|
17,095 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: End stage renal disease — AUROC: 0.64915 R²: 0.03151 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013329 585.5, 585.6,N18.5, N18.6 —
[
  • 512 cases
  • , 16,583 controls
]
,
44.72 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013330 585.5, 585.6,N18.5, N18.6 —
[
  • 512 cases
  • , 16,583 controls
]
,
44.72 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013331 585.5, 585.6,N18.5, N18.6 —
[
  • 512 cases
  • , 16,583 controls
]
,
44.72 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013332 585.5, 585.6,N18.5, N18.6 —
[
  • 512 cases
  • , 16,583 controls
]
,
44.72 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013333 585.5, 585.6,N18.5, N18.6 —
[
  • 512 cases
  • , 16,583 controls
]
,
44.72 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —