Trait: diverticular disease

Experimental Factor Ontology (EFO) Information
Identifier EFO_0009959
Description A complex disorder characterised by mucosal outpouchings (diverticulae) of the colonic wall which can become infected and inflamed leading to diverticulitis, perforation and bleeding.
Trait category
Digestive system disorder
Mapped term MedDRA:10013534
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "diverticular disease" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000996
(GBE_HC262)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Diverticular disease/diverticulitis diverticular disease,
diverticulitis
368
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000996/ScoringFiles/PGS000996.txt.gz
PGS000996
(GBE_HC262)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Diverticular disease/diverticulitis diverticular disease,
diverticulitis
368
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000996/ScoringFiles/PGS000996.txt.gz
PGS000997
(GBE_HC1106)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Diverticular disease of intestine (time-to-event) diverticular disease 5,757
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000997/ScoringFiles/PGS000997.txt.gz
PGS001369
(GBE_HC1090)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Acute appendicitis (time-to-event) appendicitis 4
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001369/ScoringFiles/PGS001369.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007743 PGS000996
(GBE_HC262)
PSS004389|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.86271 [0.73099, 0.99443] : 0.12936
Incremental AUROC (full-covars): 0.00213
PGS R2 (no covariates): 0.00894
PGS AUROC (no covariates): 0.62053 [0.46342, 0.77764]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007744 PGS000996
(GBE_HC262)
PSS004390|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.91481 [0.74874, 1.0] : 0.2785
Incremental AUROC (full-covars): 0.00029
PGS R2 (no covariates): 0.03618
PGS AUROC (no covariates): 0.74736 [0.4992, 0.99551]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007745 PGS000996
(GBE_HC262)
PSS004391|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.70041 [0.67086, 0.72996] : 0.04948
Incremental AUROC (full-covars): 0.0039
PGS R2 (no covariates): 0.00095
PGS AUROC (no covariates): 0.52419 [0.48988, 0.55849]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007746 PGS000996
(GBE_HC262)
PSS004392|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.80455 [0.70545, 0.90364] : 0.1
Incremental AUROC (full-covars): 0.00844
PGS R2 (no covariates): 0.00928
PGS AUROC (no covariates): 0.62862 [0.53202, 0.72522]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007747 PGS000996
(GBE_HC262)
PSS004393|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Diverticular disease/diverticulitis AUROC: 0.67555 [0.65884, 0.69227] : 0.03898
Incremental AUROC (full-covars): 0.00841
PGS R2 (no covariates): 0.00372
PGS AUROC (no covariates): 0.55186 [0.53326, 0.57047]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007748 PGS000997
(GBE_HC1106)
PSS004124|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE diverticular disease of intestine AUROC: 0.70831 [0.67789, 0.73873] : 0.07998
Incremental AUROC (full-covars): -0.0081
PGS R2 (no covariates): 0.00158
PGS AUROC (no covariates): 0.52939 [0.49423, 0.56454]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007749 PGS000997
(GBE_HC1106)
PSS004125|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE diverticular disease of intestine AUROC: 0.75551 [0.65982, 0.85119] : 0.08781
Incremental AUROC (full-covars): -0.01168
PGS R2 (no covariates): 0.00059
PGS AUROC (no covariates): 0.52785 [0.41459, 0.64111]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007750 PGS000997
(GBE_HC1106)
PSS004126|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE diverticular disease of intestine AUROC: 0.7155 [0.70514, 0.72586] : 0.10502
Incremental AUROC (full-covars): 0.01733
PGS R2 (no covariates): 0.01777
PGS AUROC (no covariates): 0.59105 [0.57889, 0.60321]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007751 PGS000997
(GBE_HC1106)
PSS004127|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE diverticular disease of intestine AUROC: 0.73365 [0.70818, 0.75911] : 0.09377
Incremental AUROC (full-covars): 0.01275
PGS R2 (no covariates): 0.01222
PGS AUROC (no covariates): 0.57957 [0.54784, 0.6113]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007752 PGS000997
(GBE_HC1106)
PSS004128|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE diverticular disease of intestine AUROC: 0.68053 [0.67412, 0.68694] : 0.07483
Incremental AUROC (full-covars): 0.01974
PGS R2 (no covariates): 0.01533
PGS AUROC (no covariates): 0.5794 [0.57219, 0.58662]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005205 PGS001369
(GBE_HC1090)
PSS004099|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE acute appendicitis AUROC: 0.62041 [0.53518, 0.70564] : 0.03016
Incremental AUROC (full-covars): -0.00198
PGS R2 (no covariates): 0.00105
PGS AUROC (no covariates): 0.47489 [0.37525, 0.57453]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005206 PGS001369
(GBE_HC1090)
PSS004100|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE acute appendicitis AUROC: 0.8493 [0.77779, 0.9208] : 0.14577
Incremental AUROC (full-covars): 0.00105
PGS R2 (no covariates): 0.00332
PGS AUROC (no covariates): 0.51032 [0.33889, 0.68176]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005207 PGS001369
(GBE_HC1090)
PSS004101|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE acute appendicitis AUROC: 0.56849 [0.52835, 0.60862] : 0.00702
Incremental AUROC (full-covars): -0.00219
PGS R2 (no covariates): 0.0
PGS AUROC (no covariates): 0.49616 [0.45378, 0.53854]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005208 PGS001369
(GBE_HC1090)
PSS004102|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE acute appendicitis AUROC: 0.72977 [0.65912, 0.80042] : 0.05613
Incremental AUROC (full-covars): 0.00039
PGS R2 (no covariates): 0.00096
PGS AUROC (no covariates): 0.5334 [0.44427, 0.62254]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM005209 PGS001369
(GBE_HC1090)
PSS004103|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: TTE acute appendicitis AUROC: 0.57413 [0.55138, 0.59688] : 0.00617
Incremental AUROC (full-covars): 0.00987
PGS R2 (no covariates): 0.00332
PGS AUROC (no covariates): 0.55036 [0.52746, 0.57326]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004124
[
  • 279 cases
  • , 6,218 controls
]
African unspecified UKB
PSS004125
[
  • 24 cases
  • , 1,680 controls
]
East Asian UKB
PSS004126
[
  • 2,245 cases
  • , 22,660 controls
]
European non-white British ancestry UKB
PSS004127
[
  • 330 cases
  • , 7,501 controls
]
South Asian UKB
PSS004128
[
  • 6,501 cases
  • , 60,924 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004099
[
  • 35 cases
  • , 6,462 controls
]
African unspecified UKB
PSS004100
[
  • 9 cases
  • , 1,695 controls
]
East Asian UKB
PSS004389
[
  • 11 cases
  • , 6,486 controls
]
African unspecified UKB
PSS004390
[
  • 2 cases
  • , 1,702 controls
]
East Asian UKB
PSS004391
[
  • 267 cases
  • , 24,638 controls
]
European non-white British ancestry UKB
PSS004392
[
  • 14 cases
  • , 7,817 controls
]
South Asian UKB
PSS004393
[
  • 917 cases
  • , 66,508 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS004101
[
  • 190 cases
  • , 24,715 controls
]
European non-white British ancestry UKB
PSS004102
[
  • 37 cases
  • , 7,794 controls
]
South Asian UKB
PSS004103
[
  • 612 cases
  • , 66,813 controls
]
European white British ancestry UKB Testing cohort (heldout set)