Trait: diverticulitis

Trait Information
Identifier MONDO_0004235
Description An infection that develops in the diverticula of the intestinal tract. Signs and symptoms include abdominal pain, fever, and leukocytosis. [NCIT: C26752]
Trait category
Other trait
Synonyms 2 synonyms
  • digestive tract diverticulum inflammation
  • inflammation of digestive tract diverticulum
Mapped terms 7 mapped terms
  • DOID:7475
  • EFO:1001460
  • MEDGEN:41629
  • MESH:D004238
  • NCIT:C26752
  • SCTID:307496006
  • UMLS:C0012813

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000996
(GBE_HC262)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Diverticular disease/diverticulitis diverticular disease,
diverticulitis		 368
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000996/ScoringFiles/PGS000996.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007743 PGS000996
(GBE_HC262)
 PSS004389|
African Ancestry|
6,497 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Diverticular disease/diverticulitis — AUROC: 0.86271 [0.73099, 0.99443] R²: 0.12936
Incremental AUROC (full-covars): 0.00213
PGS R2 (no covariates): 0.00894
PGS AUROC (no covariates): 0.62053 [0.46342, 0.77764]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007744 PGS000996
(GBE_HC262)
 PSS004390|
East Asian Ancestry|
1,704 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Diverticular disease/diverticulitis — AUROC: 0.91481 [0.74874, 1.0] R²: 0.2785
Incremental AUROC (full-covars): 0.00029
PGS R2 (no covariates): 0.03618
PGS AUROC (no covariates): 0.74736 [0.4992, 0.99551]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007745 PGS000996
(GBE_HC262)
 PSS004391|
European Ancestry|
24,905 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Diverticular disease/diverticulitis — AUROC: 0.70041 [0.67086, 0.72996] R²: 0.04948
Incremental AUROC (full-covars): 0.0039
PGS R2 (no covariates): 0.00095
PGS AUROC (no covariates): 0.52419 [0.48988, 0.55849]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007746 PGS000996
(GBE_HC262)
 PSS004392|
South Asian Ancestry|
7,831 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Diverticular disease/diverticulitis — AUROC: 0.80455 [0.70545, 0.90364] R²: 0.1
Incremental AUROC (full-covars): 0.00844
PGS R2 (no covariates): 0.00928
PGS AUROC (no covariates): 0.62862 [0.53202, 0.72522]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007747 PGS000996
(GBE_HC262)
 PSS004393|
European Ancestry|
67,425 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Diverticular disease/diverticulitis — AUROC: 0.67555 [0.65884, 0.69227] R²: 0.03898
Incremental AUROC (full-covars): 0.00841
PGS R2 (no covariates): 0.00372
PGS AUROC (no covariates): 0.55186 [0.53326, 0.57047]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004389 — —
[
  • 11 cases
  • , 6,486 controls
]
 — African unspecified — UKB —
PSS004390 — —
[
  • 2 cases
  • , 1,702 controls
]
 — East Asian — UKB —
PSS004391 — —
[
  • 267 cases
  • , 24,638 controls
]
 — European non-white British ancestry UKB —
PSS004392 — —
[
  • 14 cases
  • , 7,817 controls
]
 — South Asian — UKB —
PSS004393 — —
[
  • 917 cases
  • , 66,508 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)