Trait: corneal hysteresis

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010066
Description A measure of the biomechanical properties of the cornea. Low corneal hysteresis may be indicative of keratoconus.
Trait category
Other measurement
Mapped term PMID:31246245

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001380
(GBE_INI5264)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Corneal hysteresis (L) corneal hysteresis 2,240
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001380/ScoringFiles/PGS001380.txt.gz
PGS001381
(GBE_INI5256)
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Corneal hysteresis (R) corneal hysteresis 2,500
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001381/ScoringFiles/PGS001381.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007210 PGS001380
(GBE_INI5264)
 PSS007466|
African Ancestry|
3,212 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (L) — — R²: 0.01964 [0.01296, 0.02632]
Incremental R2 (full-covars): 0.00556
PGS R2 (no covariates): 0.00796 [0.00366, 0.01226]		 age, sex, UKB array type, Genotype PCs —
PPM007211 PGS001380
(GBE_INI5264)
 PSS007467|
East Asian Ancestry|
583 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (L) — — R²: 0.02789 [0.0125, 0.04327]
Incremental R2 (full-covars): 0.0055
PGS R2 (no covariates): 0.00836 [-0.00023, 0.01696]		 age, sex, UKB array type, Genotype PCs —
PPM007212 PGS001380
(GBE_INI5264)
 PSS007468|
European Ancestry|
7,806 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (L) — — R²: 0.0381 [0.03343, 0.04276]
Incremental R2 (full-covars): 0.02407
PGS R2 (no covariates): 0.02484 [0.02102, 0.02866]		 age, sex, UKB array type, Genotype PCs —
PPM007213 PGS001380
(GBE_INI5264)
 PSS007469|
South Asian Ancestry|
3,565 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (L) — — R²: 0.02621 [0.01923, 0.03319]
Incremental R2 (full-covars): 0.01
PGS R2 (no covariates): 0.0108 [0.00625, 0.01535]		 age, sex, UKB array type, Genotype PCs —
PPM007214 PGS001380
(GBE_INI5264)
 PSS007470|
European Ancestry|
16,274 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (L) — — R²: 0.04917 [0.04599, 0.05236]
Incremental R2 (full-covars): 0.0339
PGS R2 (no covariates): 0.03504 [0.03231, 0.03776]		 age, sex, UKB array type, Genotype PCs —
PPM007190 PGS001381
(GBE_INI5256)
 PSS007446|
African Ancestry|
3,254 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (R) — — R²: 0.01474 [0.00893, 0.02056]
Incremental R2 (full-covars): 0.00536
PGS R2 (no covariates): 0.0069 [0.00289, 0.01091]		 age, sex, UKB array type, Genotype PCs —
PPM007191 PGS001381
(GBE_INI5256)
 PSS007447|
East Asian Ancestry|
590 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (R) — — R²: 0.04046 [0.02217, 0.05875]
Incremental R2 (full-covars): 0.01724
PGS R2 (no covariates): 0.0202 [0.007, 0.03339]		 age, sex, UKB array type, Genotype PCs —
PPM007192 PGS001381
(GBE_INI5256)
 PSS007448|
European Ancestry|
7,821 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (R) — — R²: 0.05427 [0.0488, 0.05974]
Incremental R2 (full-covars): 0.03632
PGS R2 (no covariates): 0.03841 [0.03373, 0.04309]		 age, sex, UKB array type, Genotype PCs —
PPM007193 PGS001381
(GBE_INI5256)
 PSS007449|
South Asian Ancestry|
3,610 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (R) — — R²: 0.01868 [0.01274, 0.02462]
Incremental R2 (full-covars): 0.01038
PGS R2 (no covariates): 0.01133 [0.00667, 0.01599]		 age, sex, UKB array type, Genotype PCs —
PPM007194 PGS001381
(GBE_INI5256)
 PSS007450|
European Ancestry|
16,290 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Corneal hysteresis (R) — — R²: 0.05727 [0.05386, 0.06067]
Incremental R2 (full-covars): 0.03743
PGS R2 (no covariates): 0.03774 [0.03492, 0.04056]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007466 — — 3,212 individuals — African unspecified — UKB —
PSS007467 — — 583 individuals — East Asian — UKB —
PSS007468 — — 7,806 individuals — European non-white British ancestry UKB —
PSS007469 — — 3,565 individuals — South Asian — UKB —
PSS007470 — — 16,274 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS007446 — — 3,254 individuals — African unspecified — UKB —
PSS007447 — — 590 individuals — East Asian — UKB —
PSS007448 — — 7,821 individuals — European non-white British ancestry UKB —
PSS007449 — — 3,610 individuals — South Asian — UKB —
PSS007450 — — 16,290 individuals — European white British ancestry UKB Testing cohort (heldout set)