Trait: aspartate aminotransferase to alanine aminotransferase ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010934
Description The ratio between the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Trait category
Other measurement
Synonym AST:ALT ratio
Mapped term PMID:33004991

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Multi-ancestry (excluding European)
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South Asian
Additional Asian Ancestries
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000674
(snpnet.AST_ALT_ratio)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 AST to ALT ratio aspartate aminotransferase to alanine aminotransferase ratio 15,548
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 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000674/ScoringFiles/PGS000674.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001437 PGS000674
(snpnet.AST_ALT_ratio)
 PSS000618|
East Asian Ancestry|
1,069 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: AST to ALT ratio — — Spearman's ρ: 0.14
R²: 0.16003		 Age, sex, PCs(1-40) —
PPM001402 PGS000674
(snpnet.AST_ALT_ratio)
 PSS000617|
African Ancestry|
5,981 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: AST to ALT ratio — — R²: 0.10039
Spearman's ρ: 0.108		 Age, sex, PCs(1-40) —
PPM001472 PGS000674
(snpnet.AST_ALT_ratio)
 PSS000619|
European Ancestry|
23,478 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: AST to ALT ratio — — R²: 0.17913
Spearman's ρ: 0.256		 Age, sex, PCs(1-40) —
PPM001507 PGS000674
(snpnet.AST_ALT_ratio)
 PSS000620|
South Asian Ancestry|
7,309 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: AST to ALT ratio — — R²: 0.16338
Spearman's ρ: 0.204		 Age, sex, PCs(1-40) —
PPM001542 PGS000674
(snpnet.AST_ALT_ratio)
 PSS000621|
European Ancestry|
63,545 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: AST to ALT ratio — — R²: 0.16733
Spearman's ρ: 0.272		 Age, sex, PCs(1-40) —
PPM007295 PGS000674
(snpnet.AST_ALT_ratio)
 PSS006906|
African Ancestry|
5,981 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: AST to ALT ratio — — R²: 0.01466 [0.00886, 0.02046]
Incremental R2 (full-covars): 0.00987
PGS R2 (no covariates): 0.01069 [0.00572, 0.01566]		 age, sex, UKB array type, Genotype PCs —
PPM007296 PGS000674
(snpnet.AST_ALT_ratio)
 PSS006907|
East Asian Ancestry|
1,564 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: AST to ALT ratio — — R²: 0.02597 [0.01109, 0.04085]
Incremental R2 (full-covars): 0.01695
PGS R2 (no covariates): 0.01781 [0.00539, 0.03023]		 age, sex, UKB array type, Genotype PCs —
PPM007297 PGS000674
(snpnet.AST_ALT_ratio)
 PSS006908|
European Ancestry|
23,476 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: AST to ALT ratio — — R²: 0.0729 [0.06668, 0.07911]
Incremental R2 (full-covars): 0.07099
PGS R2 (no covariates): 0.07181 [0.06563, 0.07799]		 age, sex, UKB array type, Genotype PCs —
PPM007298 PGS000674
(snpnet.AST_ALT_ratio)
 PSS006909|
South Asian Ancestry|
7,258 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: AST to ALT ratio — — R²: 0.04818 [0.03893, 0.05743]
Incremental R2 (full-covars): 0.04091
PGS R2 (no covariates): 0.04147 [0.03283, 0.05012]		 age, sex, UKB array type, Genotype PCs —
PPM007299 PGS000674
(snpnet.AST_ALT_ratio)
 PSS006910|
European Ancestry|
63,540 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
|Ext.		 Reported Trait: AST to ALT ratio — — R²: 0.07733 [0.07346, 0.08121]
Incremental R2 (full-covars): 0.07732
PGS R2 (no covariates): 0.07746 [0.07358, 0.08133]		 age, sex, UKB array type, Genotype PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006908 — — 23,476 individuals — European non-white British ancestry UKB —
PSS006909 — — 7,258 individuals — South Asian — UKB —
PSS000617 — — 5,981 individuals — African unspecified — UKB —
PSS000618 — — 1,069 individuals — East Asian — UKB —
PSS000619 — — 23,478 individuals — European Non-British White UKB —
PSS000620 — — 7,309 individuals — South Asian — UKB —
PSS000621 — — 63,545 individuals — European
(British)		 — UKB —
PSS006910 — — 63,540 individuals — European white British ancestry UKB Testing cohort (heldout set)
PSS006906 — — 5,981 individuals — African unspecified — UKB —
PSS006907 — — 1,564 individuals — East Asian — UKB —