Trait: aspartate aminotransferase to alanine aminotransferase ratio

Experimental Factor Ontology (EFO) Information
Identifier EFO_0010934
Description
  • The ratio between the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT).
Trait category
Other measurement
Synonyms AST:ALT ratio
Mapped term(s) PMID:33004991

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution PGS Scoring File (FTP Link)
PGS000674
(snpnet.AST_ALT_ratio)
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
AST to ALT ratio aspartate aminotransferase to alanine aminotransferase ratio 15,548
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http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000674/ScoringFiles/PGS000674.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001542 PGS000674
(snpnet.AST_ALT_ratio)
PSS000621|
European Ancestry|
63,545 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio : 0.16733
Spearman's ρ: 0.272
Age, sex, PCs(1-40)
PPM001507 PGS000674
(snpnet.AST_ALT_ratio)
PSS000620|
South Asian Ancestry|
7,309 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio : 0.16338
Spearman's ρ: 0.204
Age, sex, PCs(1-40)
PPM001472 PGS000674
(snpnet.AST_ALT_ratio)
PSS000619|
European Ancestry|
23,478 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio : 0.17913
Spearman's ρ: 0.256
Age, sex, PCs(1-40)
PPM001437 PGS000674
(snpnet.AST_ALT_ratio)
PSS000618|
East Asian Ancestry|
1,069 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio : 0.16003
Spearman's ρ: 0.14
Age, sex, PCs(1-40)
PPM001402 PGS000674
(snpnet.AST_ALT_ratio)
PSS000617|
African Ancestry|
5,981 individuals
PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: AST to ALT ratio : 0.10039
Spearman's ρ: 0.108
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000617 5,981 individuals African unspecified UKB
PSS000618 1,069 individuals East Asian UKB
PSS000619 23,478 individuals European Non-British White UKB
PSS000620 7,309 individuals South Asian UKB
PSS000621 63,545 individuals European
(British)
UKB