Trait: health-related quality of life measurement

Experimental Factor Ontology (EFO) Information
Identifier EFO_0011014
Description A measure to assess health-related quality of life (HRQOL), which domains include physical health, emotional health, cognitive functioning, fatigue and pain.
Trait category
Other measurement
Synonym HRQOL
Mapped term PMID:33578652

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS001384
(GBE_INI21060)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Degree bothered by feeling tired all the time in the last 3 months health-related quality of life measurement 1,526
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001384/ScoringFiles/PGS001384.txt.gz
PGS001385
(GBE_INI21051)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Degree bothered by headaches in the last 3 months health-related quality of life measurement 9
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001385/ScoringFiles/PGS001385.txt.gz
PGS001386
(GBE_INI21049)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Degree bothered by pain in arms/legs/joints in the past 3 months health-related quality of life measurement 534
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001386/ScoringFiles/PGS001386.txt.gz
PGS001387
(GBE_INI21058)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Degree bothered by urinary frequency/bladder irritability in the last 3 months health-related quality of life measurement 333
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001387/ScoringFiles/PGS001387.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM005285 PGS001384
(GBE_INI21060)
PSS004946|
African Ancestry|
1,001 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by feeling tired all the time in the last 3 months : 0.09569 [0.08209, 0.10929]
Incremental R2 (full-covars): 0.0007
PGS R2 (no covariates): 0.00137 [-0.00043, 0.00317]
age, sex, UKB array type, Genotype PCs
PPM005286 PGS001384
(GBE_INI21060)
PSS004947|
East Asian Ancestry|
396 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by feeling tired all the time in the last 3 months : 0.01263 [0.00211, 0.02314]
Incremental R2 (full-covars): -0.00541
PGS R2 (no covariates): 0.00111 [-0.00204, 0.00426]
age, sex, UKB array type, Genotype PCs
PPM005287 PGS001384
(GBE_INI21060)
PSS004948|
European Ancestry|
9,142 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by feeling tired all the time in the last 3 months : 0.02527 [0.02142, 0.02912]
Incremental R2 (full-covars): 0.00181
PGS R2 (no covariates): 0.00196 [0.00086, 0.00306]
age, sex, UKB array type, Genotype PCs
PPM005288 PGS001384
(GBE_INI21060)
PSS004949|
South Asian Ancestry|
1,195 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by feeling tired all the time in the last 3 months : 0.06915 [0.05831, 0.07999]
Incremental R2 (full-covars): -0.00114
PGS R2 (no covariates): 0.00011 [-0.00036, 0.00058]
age, sex, UKB array type, Genotype PCs
PPM005289 PGS001384
(GBE_INI21060)
PSS004950|
European Ancestry|
24,446 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by feeling tired all the time in the last 3 months : 0.02337 [0.02111, 0.02562]
Incremental R2 (full-covars): 0.00111
PGS R2 (no covariates): 0.00164 [0.00103, 0.00225]
age, sex, UKB array type, Genotype PCs
PPM005275 PGS001385
(GBE_INI21051)
PSS004936|
African Ancestry|
1,001 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by headaches in the last 3 months : 0.07897 [0.06639, 0.09155]
Incremental R2 (full-covars): -0.00025
PGS R2 (no covariates): 1e-05 [-0.00011, 0.00012]
age, sex, UKB array type, Genotype PCs
PPM005276 PGS001385
(GBE_INI21051)
PSS004937|
East Asian Ancestry|
396 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by headaches in the last 3 months : 0.06474 [0.04219, 0.0873]
Incremental R2 (full-covars): 0.00012
PGS R2 (no covariates): 0.00041 [-0.00151, 0.00232]
age, sex, UKB array type, Genotype PCs
PPM005277 PGS001385
(GBE_INI21051)
PSS004938|
European Ancestry|
9,142 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by headaches in the last 3 months : 0.05819 [0.05255, 0.06383]
Incremental R2 (full-covars): 0.00083
PGS R2 (no covariates): 0.00259 [0.00133, 0.00385]
age, sex, UKB array type, Genotype PCs
PPM005278 PGS001385
(GBE_INI21051)
PSS004939|
South Asian Ancestry|
1,195 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by headaches in the last 3 months : 0.09268 [0.08045, 0.10491]
Incremental R2 (full-covars): 0.00089
PGS R2 (no covariates): 0.00183 [-0.00006, 0.00371]
age, sex, UKB array type, Genotype PCs
PPM005279 PGS001385
(GBE_INI21051)
PSS004940|
European Ancestry|
24,455 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by headaches in the last 3 months : 0.06122 [0.05772, 0.06473]
Incremental R2 (full-covars): 0.00053
PGS R2 (no covariates): 0.00089 [0.00044, 0.00134]
age, sex, UKB array type, Genotype PCs
PPM005270 PGS001386
(GBE_INI21049)
PSS004931|
African Ancestry|
1,002 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by pain in arms/legs/joints in the past 3 months : 0.04832 [0.03815, 0.05849]
Incremental R2 (full-covars): -0.00055
PGS R2 (no covariates): 6e-05 [-0.00033, 0.00046]
age, sex, UKB array type, Genotype PCs
PPM005271 PGS001386
(GBE_INI21049)
PSS004932|
East Asian Ancestry|
396 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by pain in arms/legs/joints in the past 3 months : 0.04977 [0.02968, 0.06986]
Incremental R2 (full-covars): 0.00065
PGS R2 (no covariates): 0.0014 [-0.00214, 0.00493]
age, sex, UKB array type, Genotype PCs
PPM005272 PGS001386
(GBE_INI21049)
PSS004933|
European Ancestry|
9,141 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by pain in arms/legs/joints in the past 3 months : 0.01604 [0.01295, 0.01914]
Incremental R2 (full-covars): 0.00043
PGS R2 (no covariates): 0.00057 [-0.00002, 0.00116]
age, sex, UKB array type, Genotype PCs
PPM005273 PGS001386
(GBE_INI21049)
PSS004934|
South Asian Ancestry|
1,195 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by pain in arms/legs/joints in the past 3 months : 0.02804 [0.02084, 0.03525]
Incremental R2 (full-covars): 0.00067
PGS R2 (no covariates): 0.00053 [-0.00049, 0.00155]
age, sex, UKB array type, Genotype PCs
PPM005274 PGS001386
(GBE_INI21049)
PSS004935|
European Ancestry|
24,448 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by pain in arms/legs/joints in the past 3 months : 0.01206 [0.01042, 0.0137]
Incremental R2 (full-covars): 0.00085
PGS R2 (no covariates): 0.00086 [0.00042, 0.0013]
age, sex, UKB array type, Genotype PCs
PPM005280 PGS001387
(GBE_INI21058)
PSS004941|
African Ancestry|
951 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by urinary frequency/bladder irritability in the last 3 months : 0.02241 [0.01511, 0.02971]
Incremental R2 (full-covars): 0.00284
PGS R2 (no covariates): 0.00528 [0.00167, 0.00889]
age, sex, UKB array type, Genotype PCs
PPM005281 PGS001387
(GBE_INI21058)
PSS004942|
East Asian Ancestry|
377 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by urinary frequency/bladder irritability in the last 3 months : 0.04327 [0.02393, 0.06261]
Incremental R2 (full-covars): -0.00355
PGS R2 (no covariates): 0.00165 [-0.00229, 0.00559]
age, sex, UKB array type, Genotype PCs
PPM005282 PGS001387
(GBE_INI21058)
PSS004943|
European Ancestry|
8,655 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by urinary frequency/bladder irritability in the last 3 months : 0.02076 [0.01716, 0.02436]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00039 [-0.00011, 0.0009]
age, sex, UKB array type, Genotype PCs
PPM005283 PGS001387
(GBE_INI21058)
PSS004944|
South Asian Ancestry|
1,142 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by urinary frequency/bladder irritability in the last 3 months : 0.02546 [0.0184, 0.03253]
Incremental R2 (full-covars): 0.0
PGS R2 (no covariates): 0.00012 [-0.00038, 0.00061]
age, sex, UKB array type, Genotype PCs
PPM005284 PGS001387
(GBE_INI21058)
PSS004945|
European Ancestry|
23,185 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Degree bothered by urinary frequency/bladder irritability in the last 3 months : 0.01566 [0.01375, 0.01757]
Incremental R2 (full-covars): 0.00087
PGS R2 (no covariates): 0.00093 [0.00046, 0.0014]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004931 1,002 individuals African unspecified UKB
PSS004932 396 individuals East Asian UKB
PSS004933 9,141 individuals European non-white British ancestry UKB
PSS004934 1,195 individuals South Asian UKB
PSS004935 24,448 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS004936 1,001 individuals African unspecified UKB
PSS004937 396 individuals East Asian UKB
PSS004938 9,142 individuals European non-white British ancestry UKB
PSS004939 1,195 individuals South Asian UKB
PSS004940 24,455 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS004941 951 individuals African unspecified UKB
PSS004942 377 individuals East Asian UKB
PSS004943 8,655 individuals European non-white British ancestry UKB
PSS004944 1,142 individuals South Asian UKB
PSS004945 23,185 individuals European white British ancestry UKB Testing cohort (heldout set)
PSS004946 1,001 individuals African unspecified UKB
PSS004947 396 individuals East Asian UKB
PSS004948 9,142 individuals European non-white British ancestry UKB
PSS004949 1,195 individuals South Asian UKB
PSS004950 24,446 individuals European white British ancestry UKB Testing cohort (heldout set)