Trait: Epidermal Inclusion Cyst

Experimental Factor Ontology (EFO) Information
Identifier EFO_1000243
Description Epidermal inclusion cyst (EIC), also known as sebaceous cyst and epidermoid cyst, is the most common cyst of the skin. It ranges in size from a few millimeters to a few centimeters and originates from the follicular infundibulum. Its contents are a cheesy, malodorous mixture of degraded lipid and keratin. It often ruptures, with associated pain and inflammation. (http://www.medicinenet.com/image-collection/epidermal_inclusion_cyst_eic_picture/picture.htm)
Trait category
Other disease
Synonyms 3 synonyms
  • EIC
  • epidermoid cyst
  • sebaceous cyst
Mapped terms 2 mapped terms
  • MedDRA:10014984
  • NCIt:C3134

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001874
(portability-PLR_706.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sebaceous cyst Epidermal Inclusion Cyst 563
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001874/ScoringFiles/PGS001874.txt.gz
PGS002087
(portability-ldpred2_706.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Sebaceous cyst Epidermal Inclusion Cyst 206,669
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002087/ScoringFiles/PGS002087.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009880 PGS001874
(portability-PLR_706.2)
 PSS009351|
European Ancestry|
19,952 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0461 [0.0323, 0.06] sex, age, birth date, deprivation index, 16 PCs —
PPM009881 PGS001874
(portability-PLR_706.2)
 PSS009125|
European Ancestry|
4,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0709 [0.0404, 0.1013] sex, age, birth date, deprivation index, 16 PCs —
PPM009882 PGS001874
(portability-PLR_706.2)
 PSS008679|
European Ancestry|
6,646 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0466 [0.0225, 0.0706] sex, age, birth date, deprivation index, 16 PCs —
PPM009883 PGS001874
(portability-PLR_706.2)
 PSS008453|
Greater Middle Eastern Ancestry|
1,194 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0522 [-0.005, 0.1091] sex, age, birth date, deprivation index, 16 PCs —
PPM009884 PGS001874
(portability-PLR_706.2)
 PSS008233|
South Asian Ancestry|
6,311 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.049 [0.0243, 0.0736] sex, age, birth date, deprivation index, 16 PCs —
PPM009885 PGS001874
(portability-PLR_706.2)
 PSS008013|
East Asian Ancestry|
1,807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0163 [-0.0627, 0.0301] sex, age, birth date, deprivation index, 16 PCs —
PPM009886 PGS001874
(portability-PLR_706.2)
 PSS007798|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0263 [-0.0659, 0.0133] sex, age, birth date, deprivation index, 16 PCs —
PPM009887 PGS001874
(portability-PLR_706.2)
 PSS008902|
African Ancestry|
3,913 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.01 [-0.0414, 0.0214] sex, age, birth date, deprivation index, 16 PCs —
PPM011556 PGS002087
(portability-ldpred2_706.2)
 PSS009351|
European Ancestry|
19,952 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0513 [0.0374, 0.0651] sex, age, birth date, deprivation index, 16 PCs —
PPM011557 PGS002087
(portability-ldpred2_706.2)
 PSS009125|
European Ancestry|
4,124 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0734 [0.0429, 0.1037] sex, age, birth date, deprivation index, 16 PCs —
PPM011558 PGS002087
(portability-ldpred2_706.2)
 PSS008679|
European Ancestry|
6,646 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0454 [0.0214, 0.0694] sex, age, birth date, deprivation index, 16 PCs —
PPM011559 PGS002087
(portability-ldpred2_706.2)
 PSS008453|
Greater Middle Eastern Ancestry|
1,194 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0444 [-0.0128, 0.1014] sex, age, birth date, deprivation index, 16 PCs —
PPM011560 PGS002087
(portability-ldpred2_706.2)
 PSS008233|
South Asian Ancestry|
6,311 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0351 [0.0103, 0.0597] sex, age, birth date, deprivation index, 16 PCs —
PPM011561 PGS002087
(portability-ldpred2_706.2)
 PSS008013|
East Asian Ancestry|
1,807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0299 [-0.0762, 0.0165] sex, age, birth date, deprivation index, 16 PCs —
PPM011562 PGS002087
(portability-ldpred2_706.2)
 PSS007798|
African Ancestry|
2,471 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): -0.0274 [-0.067, 0.0122] sex, age, birth date, deprivation index, 16 PCs —
PPM011563 PGS002087
(portability-ldpred2_706.2)
 PSS008902|
African Ancestry|
3,913 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sebaceous cyst — — Partial Correlation (partial-r): 0.0023 [-0.0291, 0.0338] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009125 — — 4,124 individuals — European Poland (NE Europe) UKB —
PSS008453 — — 1,194 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008679 — — 6,646 individuals — European Italy (South Europe) UKB —
PSS009351 — — 19,952 individuals — European UK (+ Ireland) UKB —
PSS008233 — — 6,311 individuals — South Asian India (South Asia) UKB —
PSS008902 — — 3,913 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008013 — — 1,807 individuals — East Asian China (East Asia) UKB —
PSS007798 — — 2,471 individuals — African American or Afro-Caribbean Carribean UKB —