Trait: Rh isoimmunization

Experimental Factor Ontology (EFO) Information
Identifier EFO_1001159
Description The mother develops antibodies against red blood cell Rhesus antigens. This may lead to potential fetal adverse outcomes such as anemia. [NCIT: P378]
Trait category
Other disease
Synonyms 3 synonyms
  • Rh Isoimmunization
  • Rh incompatibility affecting management of mother
  • Rh isoimmunization
Mapped terms 6 mapped terms
  • DOID:4175
  • MONDO:0006953
  • MeSH:D012203
  • MedDRA:10039016
  • SCTID:44795003
  • UMLS:C0035404

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001868
(portability-PLR_654.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Rhesus isoimmunization in pregnancy Rh isoimmunization 30
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001868/ScoringFiles/PGS001868.txt.gz
PGS002080
(portability-ldpred2_654.2)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Rhesus isoimmunization in pregnancy Rh isoimmunization 32,414
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002080/ScoringFiles/PGS002080.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009833 PGS001868
(portability-PLR_654.2)
 PSS009344|
European Ancestry|
10,686 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0509 [0.0319, 0.0698] sex, age, birth date, deprivation index, 16 PCs —
PPM009834 PGS001868
(portability-PLR_654.2)
 PSS009118|
European Ancestry|
2,539 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0603 [0.0213, 0.0991] sex, age, birth date, deprivation index, 16 PCs —
PPM009835 PGS001868
(portability-PLR_654.2)
 PSS008672|
European Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0696 [0.0369, 0.1021] sex, age, birth date, deprivation index, 16 PCs —
PPM009836 PGS001868
(portability-PLR_654.2)
 PSS008446|
Greater Middle Eastern Ancestry|
470 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0386 [-0.054, 0.1304] sex, age, birth date, deprivation index, 16 PCs —
PPM009838 PGS001868
(portability-PLR_654.2)
 PSS008007|
East Asian Ancestry|
1,173 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.052 [-0.0057, 0.1094] sex, age, birth date, deprivation index, 16 PCs —
PPM009839 PGS001868
(portability-PLR_654.2)
 PSS007791|
African Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): -0.0385 [-0.0885, 0.0116] sex, age, birth date, deprivation index, 16 PCs —
PPM009840 PGS001868
(portability-PLR_654.2)
 PSS008895|
African Ancestry|
2,068 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0144 [-0.0289, 0.0577] sex, age, birth date, deprivation index, 16 PCs —
PPM009837 PGS001868
(portability-PLR_654.2)
 PSS008226|
South Asian Ancestry|
2,815 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0639 [0.0269, 0.1008] sex, age, birth date, deprivation index, 16 PCs —
PPM011501 PGS002080
(portability-ldpred2_654.2)
 PSS009344|
European Ancestry|
10,686 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0529 [0.034, 0.0718] sex, age, birth date, deprivation index, 16 PCs —
PPM011502 PGS002080
(portability-ldpred2_654.2)
 PSS009118|
European Ancestry|
2,539 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0603 [0.0213, 0.0991] sex, age, birth date, deprivation index, 16 PCs —
PPM011503 PGS002080
(portability-ldpred2_654.2)
 PSS008672|
European Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0698 [0.0371, 0.1023] sex, age, birth date, deprivation index, 16 PCs —
PPM011504 PGS002080
(portability-ldpred2_654.2)
 PSS008446|
Greater Middle Eastern Ancestry|
470 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0432 [-0.0494, 0.135] sex, age, birth date, deprivation index, 16 PCs —
PPM011505 PGS002080
(portability-ldpred2_654.2)
 PSS008226|
South Asian Ancestry|
2,815 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0674 [0.0305, 0.1043] sex, age, birth date, deprivation index, 16 PCs —
PPM011506 PGS002080
(portability-ldpred2_654.2)
 PSS008007|
East Asian Ancestry|
1,173 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0096 [-0.0482, 0.0672] sex, age, birth date, deprivation index, 16 PCs —
PPM011508 PGS002080
(portability-ldpred2_654.2)
 PSS008895|
African Ancestry|
2,068 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0234 [-0.0199, 0.0666] sex, age, birth date, deprivation index, 16 PCs —
PPM011507 PGS002080
(portability-ldpred2_654.2)
 PSS007791|
African Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): -0.0192 [-0.0692, 0.031] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008007 — — 1,173 individuals — East Asian China (East Asia) UKB —
PSS007791 — — 1,548 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008446 — — 470 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009118 — — 2,539 individuals — European Poland (NE Europe) UKB —
PSS008895 — — 2,068 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009344 — — 10,686 individuals — European UK (+ Ireland) UKB —
PSS008672 — — 3,602 individuals — European Italy (South Europe) UKB —
PSS008226 — — 2,815 individuals — South Asian India (South Asia) UKB —