Trait: psoriasis vulgaris

Experimental Factor Ontology (EFO) Information
Identifier EFO_1001494
Description Plaque psoriasis is the most common presentation of psoriasis. It presents as small to large, well demarcated, red, scaly and thickened areas of skin. It most likely to affect elbows, knees, and lower back but may arise on any part of the body.
Trait category
Other trait
Synonym plaque psoriasis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019617
(TPMI_696.41_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 1,357
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019617/ScoringFiles/PGS019617.txt.gz
PGS019618
(TPMI_696.41_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 330,044
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019618/ScoringFiles/PGS019618.txt.gz
PGS019619
(TPMI_696.41_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 49,531
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019619/ScoringFiles/PGS019619.txt.gz
PGS019620
(TPMI_696.41_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 983,756
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019620/ScoringFiles/PGS019620.txt.gz
PGS019621
(TPMI_696.41_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 1,071,390
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019621/ScoringFiles/PGS019621.txt.gz
PGS019622
(TPMI_696.41_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Psoriasis vulgaris psoriasis vulgaris 59,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019622/ScoringFiles/PGS019622.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037799 PGS019617
(TPMI_696.41_Lassosum2)
 PSS013508|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.81124 R²: 0.072 sex, age, array, PCs 1-10 —
PPM037800 PGS019618
(TPMI_696.41_LDpred2)
 PSS013507|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.81009 R²: 0.07253 sex, age, array, PCs 1-10 —
PPM037801 PGS019619
(TPMI_696.41_MegaPRS)
 PSS013509|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.77348 R²: 0.05411 sex, age, array, PCs 1-10 —
PPM037802 PGS019620
(TPMI_696.41_PRS-CS)
 PSS013510|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.7987 R²: 0.06619 sex, age, array, PCs 1-10 —
PPM037803 PGS019621
(TPMI_696.41_PRSmix+)
 PSS013511|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.82206 R²: 0.07724 sex, age, array, PCs 1-10 —
PPM037804 PGS019622
(TPMI_696.41_SBayesR)
 PSS013512|
East Asian Ancestry|
17,325 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Psoriasis vulgaris — AUROC: 0.80295 R²: 0.06762 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013507 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013508 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013509 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013510 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013511 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013512 696.1,L40.0, L40.2, L40.3, L40.4, L40.8, L40.9 —
[
  • 275 cases
  • , 17,050 controls
]
,
48.39 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —