Trait: ventral hernia

Experimental Factor Ontology (EFO) Information
Identifier EFO_1001866
Description A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.
Trait category
Other trait
Synonyms 2 synonyms
  • Hernia, Ventral
  • hernia of anterior abdominal wall

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019340
(TPMI_550_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abdominal hernia ventral hernia 10,749
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019340/ScoringFiles/PGS019340.txt.gz
PGS019341
(TPMI_550_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abdominal hernia ventral hernia 328,473
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019341/ScoringFiles/PGS019341.txt.gz
PGS019342
(TPMI_550_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abdominal hernia ventral hernia 20,055
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019342/ScoringFiles/PGS019342.txt.gz
PGS019343
(TPMI_550_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abdominal hernia ventral hernia 983,829
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019343/ScoringFiles/PGS019343.txt.gz
PGS019344
(TPMI_550_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Abdominal hernia ventral hernia 1,002,973
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019344/ScoringFiles/PGS019344.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037522 PGS019340
(TPMI_550_Lassosum2)
 PSS013248|
East Asian Ancestry|
19,923 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abdominal hernia — AUROC: 0.73738 R²: 0.03113 sex, age, array, PCs 1-10 —
PPM037523 PGS019341
(TPMI_550_LDpred2)
 PSS013247|
East Asian Ancestry|
19,923 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abdominal hernia — AUROC: 0.74398 R²: 0.03246 sex, age, array, PCs 1-10 —
PPM037524 PGS019342
(TPMI_550_MegaPRS)
 PSS013249|
East Asian Ancestry|
19,923 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abdominal hernia — AUROC: 0.7336 R²: 0.0311 sex, age, array, PCs 1-10 —
PPM037525 PGS019343
(TPMI_550_PRS-CS)
 PSS013250|
East Asian Ancestry|
19,923 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abdominal hernia — AUROC: 0.74653 R²: 0.03277 sex, age, array, PCs 1-10 —
PPM037526 PGS019344
(TPMI_550_SBayesR)
 PSS013251|
East Asian Ancestry|
19,923 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Abdominal hernia — AUROC: 0.73928 R²: 0.03167 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013247 550, 551, 552, 553,K40, K41, K42, K43, K44, K45, K46 —
[
  • 284 cases
  • , 19,639 controls
]
,
45.87 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013248 550, 551, 552, 553,K40, K41, K42, K43, K44, K45, K46 —
[
  • 284 cases
  • , 19,639 controls
]
,
45.87 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013249 550, 551, 552, 553,K40, K41, K42, K43, K44, K45, K46 —
[
  • 284 cases
  • , 19,639 controls
]
,
45.87 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013250 550, 551, 552, 553,K40, K41, K42, K43, K44, K45, K46 —
[
  • 284 cases
  • , 19,639 controls
]
,
45.87 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013251 550, 551, 552, 553,K40, K41, K42, K43, K44, K45, K46 —
[
  • 284 cases
  • , 19,639 controls
]
,
45.87 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —