Trait: response to statin

Trait Information
Identifier GO_0036273
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus, a compound that inhibits HMG-CoA reductases.
Trait categories
Biological process
Response to drug

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS002730
(GRSlipid_35)
PGP000337 |
Mayerhofer E et al. Brain (2022)
LDL lowering in response to statin low density lipoprotein cholesterol measurement,
response to statin
35
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002730/ScoringFiles/PGS002730.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014797 PGS002730
(GRSlipid_35)
PSS009892|
European Ancestry|
75,973 individuals
PGP000337 |
Mayerhofer E et al. Brain (2022)
Reported Trait: On-statin LDL decrease β: -0.05 [-0.07, -0.02]
PPM014798 PGS002730
(GRSlipid_35)
PSS009892|
European Ancestry|
75,973 individuals
PGP000337 |
Mayerhofer E et al. Brain (2022)
Reported Trait: Incident intracerebral hemorrhage HR: 1.16 [1.05, 1.28]
PPM014799 PGS002730
(GRSlipid_35)
PSS009892|
European Ancestry|
75,973 individuals
PGP000337 |
Mayerhofer E et al. Brain (2022)
Reported Trait: Incident myocardial infarction HR: 0.98 [0.96, 0.99]
PPM014800 PGS002730
(GRSlipid_35)
PSS009892|
European Ancestry|
75,973 individuals
PGP000337 |
Mayerhofer E et al. Brain (2022)
Reported Trait: Incident Peripheral Artery Disease HR: 0.93 [0.87, 0.99]

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009892 75,973 individuals,
57.2 % Male samples
Mean = 60.4 years
Sd = 6.6 years
European UKB