Trait: response to bronchodilator

Trait Information
Identifier GO_0097366
Description Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes. [GOC: hp]
Trait category
Biological process
Synonyms 2 synonyms
  • response to bronchodilator agent
  • response to broncholytic agent

Associated Polygenic Score(s)

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Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000769
(PRS16_BDR)
PGP000176 |
Sordillo JE et al. J Pers Med (2021)
Response to bronchodilator (albutamol) response to bronchodilator 16
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000769/ScoringFiles/PGS000769.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001986 PGS000769
(PRS16_BDR)
PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
PGP000176 |
Sordillo JE et al. J Pers Med (2021)
Reported Trait: Bronchodilator response ≥ 8% OR: 0.8 [0.69, 0.92] Age, body mass index, sex, PCs(1-6), doctor visits for asthma
PPM001985 PGS000769
(PRS16_BDR)
PSS000990|
Hispanic or Latin American Ancestry|
967 individuals
PGP000176 |
Sordillo JE et al. J Pers Med (2021)
Reported Trait: Bronchodilator response ≥ 12% OR: 0.8 [0.67, 0.95] Age, body mass index, sex, PCs(1-6), doctor visits for asthma

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000990 Cases are individuals with asthma and a bronchodilator response of 8% or higher. Asthma was defined as physician-diagnosed asthma and at least two respiratory symptoms or asthma attacks in the previous year. 166 of the 275 cases had a bronchodilator response of 12% or higher.
[
  • 275 cases
  • , 692 controls
]
,
59.0 % Male samples
Mean = 9.3 years
Sd = 9.1 years
Hispanic or Latin American GACRS