Trait: Urinary retention

Trait Information
Identifier HP_0000016
Description Inability to completely empty the urinary bladder during the process of urination.
Trait category
Other trait
Synonym Increased post-void residual urine volume

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019512
(TPMI_599.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Retention of urine Urinary retention 234
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019512/ScoringFiles/PGS019512.txt.gz
PGS019513
(TPMI_599.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Retention of urine Urinary retention 105,295
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019513/ScoringFiles/PGS019513.txt.gz
PGS019514
(TPMI_599.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Retention of urine Urinary retention 555,975
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019514/ScoringFiles/PGS019514.txt.gz
PGS019515
(TPMI_599.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Retention of urine Urinary retention 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019515/ScoringFiles/PGS019515.txt.gz
PGS019516
(TPMI_599.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Retention of urine Urinary retention 992,540
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019516/ScoringFiles/PGS019516.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037694 PGS019512
(TPMI_599.2_Lassosum2)
 PSS013415|
East Asian Ancestry|
17,712 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Retention of urine — AUROC: 0.63705 R²: 0.004 sex, age, array, PCs 1-10 —
PPM037695 PGS019513
(TPMI_599.2_LDpred2)
 PSS013414|
East Asian Ancestry|
17,712 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Retention of urine — AUROC: 0.6379 R²: 0.00404 sex, age, array, PCs 1-10 —
PPM037696 PGS019514
(TPMI_599.2_MegaPRS)
 PSS013416|
East Asian Ancestry|
17,712 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Retention of urine — AUROC: 0.63692 R²: 0.00401 sex, age, array, PCs 1-10 —
PPM037697 PGS019515
(TPMI_599.2_PRS-CS)
 PSS013417|
East Asian Ancestry|
17,712 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Retention of urine — AUROC: 0.63923 R²: 0.00409 sex, age, array, PCs 1-10 —
PPM037698 PGS019516
(TPMI_599.2_SBayesR)
 PSS013418|
East Asian Ancestry|
17,712 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Retention of urine — AUROC: 0.63591 R²: 0.00404 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013414 788.2,R33, R39.14 —
[
  • 112 cases
  • , 17,600 controls
]
,
45.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013415 788.2,R33, R39.14 —
[
  • 112 cases
  • , 17,600 controls
]
,
45.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013416 788.2,R33, R39.14 —
[
  • 112 cases
  • , 17,600 controls
]
,
45.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013417 788.2,R33, R39.14 —
[
  • 112 cases
  • , 17,600 controls
]
,
45.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013418 788.2,R33, R39.14 —
[
  • 112 cases
  • , 17,600 controls
]
,
45.85 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —