Trait: Polyuria

Trait Information
Identifier HP_0000103
Description An increased rate of urine production.
Trait category
Other trait
Synonym Increased urine output

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019517
(TPMI_599.5_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Frequency of urination and polyuria Polyuria 206,142
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019517/ScoringFiles/PGS019517.txt.gz
PGS019518
(TPMI_599.5_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Frequency of urination and polyuria Polyuria 939,875
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019518/ScoringFiles/PGS019518.txt.gz
PGS019519
(TPMI_599.5_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Frequency of urination and polyuria Polyuria 544,657
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019519/ScoringFiles/PGS019519.txt.gz
PGS019520
(TPMI_599.5_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Frequency of urination and polyuria Polyuria 983,815
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019520/ScoringFiles/PGS019520.txt.gz
PGS019521
(TPMI_599.5_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Frequency of urination and polyuria Polyuria 980,241
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019521/ScoringFiles/PGS019521.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037699 PGS019517
(TPMI_599.5_Lassosum2)
 PSS013420|
East Asian Ancestry|
18,276 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Frequency of urination and polyuria — AUROC: 0.55674 R²: 0.00554 sex, age, array, PCs 1-10 —
PPM037700 PGS019518
(TPMI_599.5_LDpred2)
 PSS013419|
East Asian Ancestry|
18,276 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Frequency of urination and polyuria — AUROC: 0.56132 R²: 0.00647 sex, age, array, PCs 1-10 —
PPM037701 PGS019519
(TPMI_599.5_MegaPRS)
 PSS013421|
East Asian Ancestry|
18,276 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Frequency of urination and polyuria — AUROC: 0.5573 R²: 0.0058 sex, age, array, PCs 1-10 —
PPM037702 PGS019520
(TPMI_599.5_PRS-CS)
 PSS013422|
East Asian Ancestry|
18,276 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Frequency of urination and polyuria — AUROC: 0.557 R²: 0.00557 sex, age, array, PCs 1-10 —
PPM037703 PGS019521
(TPMI_599.5_SBayesR)
 PSS013423|
East Asian Ancestry|
18,276 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Frequency of urination and polyuria — AUROC: 0.56016 R²: 0.0063 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013419 788.4,R35 —
[
  • 676 cases
  • , 17,600 controls
]
,
45.9 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013420 788.4,R35 —
[
  • 676 cases
  • , 17,600 controls
]
,
45.9 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013421 788.4,R35 —
[
  • 676 cases
  • , 17,600 controls
]
,
45.9 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013422 788.4,R35 —
[
  • 676 cases
  • , 17,600 controls
]
,
45.9 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013423 788.4,R35 —
[
  • 676 cases
  • , 17,600 controls
]
,
45.9 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —