Trait: Eczema

Trait Information
Identifier HP_0000964
Description Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. [HPO: probinson]
Trait category
Other trait
Synonym Eczema
Mapped terms 7 mapped terms
  • ICD10:L27
  • MSH:D004485
  • NCIt:C3001
  • SNOMEDCT:43116000
  • SNOMEDCT_US:281104002
  • SNOMEDCT_US:43116000
  • UMLS:C0013595

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000944
(GBE_HC261)
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Eczema, dermatitis Eczema,
dermatitis
598
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000944/ScoringFiles/PGS000944.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007546 PGS000944
(GBE_HC261)
PSS004384|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Eczema/dermatitis AUROC: 0.62856 [0.58377, 0.67334] : 0.02337
Incremental AUROC (full-covars): 0.00187
PGS R2 (no covariates): 0.00173
PGS AUROC (no covariates): 0.52778 [0.48039, 0.57516]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007547 PGS000944
(GBE_HC261)
PSS004385|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Eczema/dermatitis AUROC: 0.59588 [0.52553, 0.66622] : 0.02855
Incremental AUROC (full-covars): 0.02432
PGS R2 (no covariates): 0.0116
PGS AUROC (no covariates): 0.58664 [0.52213, 0.65115]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007548 PGS000944
(GBE_HC261)
PSS004386|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Eczema/dermatitis AUROC: 0.56459 [0.54541, 0.58377] : 0.00802
Incremental AUROC (full-covars): 0.01208
PGS R2 (no covariates): 0.00353
PGS AUROC (no covariates): 0.54597 [0.52632, 0.56561]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007549 PGS000944
(GBE_HC261)
PSS004387|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Eczema/dermatitis AUROC: 0.56106 [0.52439, 0.59773] : 0.00683
Incremental AUROC (full-covars): -0.0012
PGS R2 (no covariates): 0.00011
PGS AUROC (no covariates): 0.51686 [0.48122, 0.5525]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007550 PGS000944
(GBE_HC261)
PSS004388|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. medRxiv (2021)
|Pre
Reported Trait: Eczema/dermatitis AUROC: 0.57099 [0.55943, 0.58256] : 0.00884
Incremental AUROC (full-covars): 0.02521
PGS R2 (no covariates): 0.00527
PGS AUROC (no covariates): 0.5556 [0.54396, 0.56724]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004384
[
  • 157 cases
  • , 6,340 controls
]
African unspecified UKB
PSS004385
[
  • 66 cases
  • , 1,638 controls
]
East Asian UKB
PSS004386
[
  • 873 cases
  • , 24,032 controls
]
European non-white British ancestry UKB
PSS004387
[
  • 243 cases
  • , 7,588 controls
]
South Asian UKB
PSS004388
[
  • 2,514 cases
  • , 64,911 controls
]
European white British ancestry UKB Testing cohort (heldout set)