Trait: Eczema

Trait Information
Identifier HP_0000964
Description Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. [HPO: probinson]
Trait category
Other trait
Synonym Eczema
Mapped terms 7 mapped terms
  • ICD10:L27
  • MSH:D004485
  • NCIt:C3001
  • SNOMEDCT:43116000
  • SNOMEDCT_US:281104002
  • SNOMEDCT_US:43116000
  • UMLS:C0013595

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution Scoring File (FTP Link)
PGS000944
(GBE_HC261)
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Eczema, dermatitis Eczema,
dermatitis
598
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000944/ScoringFiles/PGS000944.txt.gz
PGS002323
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 1,109,311
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002323/ScoringFiles/PGS002323.txt.gz
PGS002363
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM-BBJ)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 920,927
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002363/ScoringFiles/PGS002363.txt.gz
PGS002395
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.0001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 4,367
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002395/ScoringFiles/PGS002395.txt.gz
PGS002444
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 16,802
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002444/ScoringFiles/PGS002444.txt.gz
PGS002493
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.01)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 100,504
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002493/ScoringFiles/PGS002493.txt.gz
PGS002542
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.1e-06)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 1,104
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002542/ScoringFiles/PGS002542.txt.gz
PGS002591
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.5e-08)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 667
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002591/ScoringFiles/PGS002591.txt.gz
PGS002640
(disease_ALLERGY_ECZEMA_DIAGNOSED.PolyFun-pred)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 241,530
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002640/ScoringFiles/PGS002640.txt.gz
PGS002689
(disease_ALLERGY_ECZEMA_DIAGNOSED.SBayesR)
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Eczema Eczema 957,578
-
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002689/ScoringFiles/PGS002689.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
Evaluated Score PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007546 PGS000944
(GBE_HC261)
PSS004384|
African Ancestry|
6,497 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eczema/dermatitis AUROC: 0.62856 [0.58377, 0.67334] : 0.02337
Incremental AUROC (full-covars): 0.00187
PGS R2 (no covariates): 0.00173
PGS AUROC (no covariates): 0.52778 [0.48039, 0.57516]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007547 PGS000944
(GBE_HC261)
PSS004385|
East Asian Ancestry|
1,704 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eczema/dermatitis AUROC: 0.59588 [0.52553, 0.66622] : 0.02855
Incremental AUROC (full-covars): 0.02432
PGS R2 (no covariates): 0.0116
PGS AUROC (no covariates): 0.58664 [0.52213, 0.65115]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007548 PGS000944
(GBE_HC261)
PSS004386|
European Ancestry|
24,905 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eczema/dermatitis AUROC: 0.56459 [0.54541, 0.58377] : 0.00802
Incremental AUROC (full-covars): 0.01208
PGS R2 (no covariates): 0.00353
PGS AUROC (no covariates): 0.54597 [0.52632, 0.56561]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007549 PGS000944
(GBE_HC261)
PSS004387|
South Asian Ancestry|
7,831 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eczema/dermatitis AUROC: 0.56106 [0.52439, 0.59773] : 0.00683
Incremental AUROC (full-covars): -0.0012
PGS R2 (no covariates): 0.00011
PGS AUROC (no covariates): 0.51686 [0.48122, 0.5525]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007550 PGS000944
(GBE_HC261)
PSS004388|
European Ancestry|
67,425 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eczema/dermatitis AUROC: 0.57099 [0.55943, 0.58256] : 0.00884
Incremental AUROC (full-covars): 0.02521
PGS R2 (no covariates): 0.00527
PGS AUROC (no covariates): 0.5556 [0.54396, 0.56724]
age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM013137 PGS002323
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0203 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013088 PGS002323
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0044 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013186 PGS002323
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0289 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013235 PGS002323
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0161 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013275 PGS002363
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013298 PGS002363
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013321 PGS002363
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013344 PGS002363
(disease_ALLERGY_ECZEMA_DIAGNOSED.BOLT-LMM-BBJ)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013376 PGS002395
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.0001)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0002 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013425 PGS002395
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.0001)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0008 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013474 PGS002395
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.0001)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.011 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013523 PGS002395
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.0001)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0024 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013572 PGS002444
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013621 PGS002444
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0007 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013670 PGS002444
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0036 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013719 PGS002444
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.001)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0004 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013768 PGS002493
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.01)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013817 PGS002493
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.01)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013866 PGS002493
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.01)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0025 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013915 PGS002493
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.0.01)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM013964 PGS002542
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.1e-06)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0006 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014013 PGS002542
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.1e-06)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0012 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014062 PGS002542
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.1e-06)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0118 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014111 PGS002542
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.1e-06)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0035 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014307 PGS002591
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.5e-08)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0031 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014160 PGS002591
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.5e-08)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0009 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014209 PGS002591
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.5e-08)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014258 PGS002591
(disease_ALLERGY_ECZEMA_DIAGNOSED.P+T.5e-08)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0099 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014356 PGS002640
(disease_ALLERGY_ECZEMA_DIAGNOSED.PolyFun-pred)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0054 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ALLERGY_ECZEMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014405 PGS002640
(disease_ALLERGY_ECZEMA_DIAGNOSED.PolyFun-pred)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0211 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ALLERGY_ECZEMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014454 PGS002640
(disease_ALLERGY_ECZEMA_DIAGNOSED.PolyFun-pred)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0309 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ALLERGY_ECZEMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014503 PGS002640
(disease_ALLERGY_ECZEMA_DIAGNOSED.PolyFun-pred)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0176 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs See disease_ALLERGY_ECZEMA_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014601 PGS002689
(disease_ALLERGY_ECZEMA_DIAGNOSED.SBayesR)
PSS009736|
East Asian Ancestry|
905 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0242 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014552 PGS002689
(disease_ALLERGY_ECZEMA_DIAGNOSED.SBayesR)
PSS009735|
African Ancestry|
6,423 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0056 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014650 PGS002689
(disease_ALLERGY_ECZEMA_DIAGNOSED.SBayesR)
PSS009737|
European Ancestry|
43,398 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0261 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs
PPM014699 PGS002689
(disease_ALLERGY_ECZEMA_DIAGNOSED.SBayesR)
PSS009738|
South Asian Ancestry|
7,942 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: Eczema Incremental R2 (full model vs. covariates alone): 0.0143 age, sex, age‚age*sex, assessment center, genotyping array, 10 PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS004384
[
  • 157 cases
  • , 6,340 controls
]
African unspecified UKB
PSS004385
[
  • 66 cases
  • , 1,638 controls
]
East Asian UKB
PSS004386
[
  • 873 cases
  • , 24,032 controls
]
European non-white British ancestry UKB
PSS004387
[
  • 243 cases
  • , 7,588 controls
]
South Asian UKB
PSS004388
[
  • 2,514 cases
  • , 64,911 controls
]
European white British ancestry UKB Testing cohort (heldout set)
PSS009735 6,423 individuals African unspecified UKB
PSS009736 905 individuals East Asian UKB
PSS009737 43,398 individuals European Non-British European UKB
PSS009738 7,942 individuals South Asian UKB