Trait: Iron deficiency anemia

Trait Information
Identifier HP_0001891
Trait category
Other trait
Synonyms 4 synonyms
  • Ferropenic
  • Iron deficiency anaemia
  • Iron-deficiency anaemia
  • Iron-deficiency anemia

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018866
(TPMI_280_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias Iron deficiency anemia 134,888
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018866/ScoringFiles/PGS018866.txt.gz
PGS018867
(TPMI_280_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias Iron deficiency anemia 939,885
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018867/ScoringFiles/PGS018867.txt.gz
PGS018868
(TPMI_280_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias Iron deficiency anemia 33,438
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018868/ScoringFiles/PGS018868.txt.gz
PGS018869
(TPMI_280_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias Iron deficiency anemia 983,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018869/ScoringFiles/PGS018869.txt.gz
PGS018870
(TPMI_280_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias Iron deficiency anemia 971,675
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018870/ScoringFiles/PGS018870.txt.gz
PGS018871
(TPMI_280.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias unspecified or not due to blood loss Iron deficiency anemia 139,349
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018871/ScoringFiles/PGS018871.txt.gz
PGS018872
(TPMI_280.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias unspecified or not due to blood loss Iron deficiency anemia 939,886
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018872/ScoringFiles/PGS018872.txt.gz
PGS018873
(TPMI_280.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias unspecified or not due to blood loss Iron deficiency anemia 32,742
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018873/ScoringFiles/PGS018873.txt.gz
PGS018874
(TPMI_280.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias unspecified or not due to blood loss Iron deficiency anemia 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018874/ScoringFiles/PGS018874.txt.gz
PGS018875
(TPMI_280.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemias unspecified or not due to blood loss Iron deficiency anemia 985,375
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018875/ScoringFiles/PGS018875.txt.gz
PGS018876
(TPMI_280.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemia secondary to blood loss chronic Iron deficiency anemia 7,519
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018876/ScoringFiles/PGS018876.txt.gz
PGS018877
(TPMI_280.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemia secondary to blood loss chronic Iron deficiency anemia 939,882
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018877/ScoringFiles/PGS018877.txt.gz
PGS018878
(TPMI_280.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemia secondary to blood loss chronic Iron deficiency anemia 494,921
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018878/ScoringFiles/PGS018878.txt.gz
PGS018879
(TPMI_280.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemia secondary to blood loss chronic Iron deficiency anemia 983,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018879/ScoringFiles/PGS018879.txt.gz
PGS018880
(TPMI_280.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Iron deficiency anemia secondary to blood loss chronic Iron deficiency anemia 1,008,543
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018880/ScoringFiles/PGS018880.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037048 PGS018866
(TPMI_280_Lassosum2)
 PSS012779|
East Asian Ancestry|
18,751 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias — AUROC: 0.83891 R²: 0.23168 sex, age, array, PCs 1-10 —
PPM037049 PGS018867
(TPMI_280_LDpred2)
 PSS012778|
East Asian Ancestry|
18,751 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias — AUROC: 0.83956 R²: 0.23227 sex, age, array, PCs 1-10 —
PPM037050 PGS018868
(TPMI_280_MegaPRS)
 PSS012780|
East Asian Ancestry|
18,751 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias — AUROC: 0.83965 R²: 0.23153 sex, age, array, PCs 1-10 —
PPM037051 PGS018869
(TPMI_280_PRS-CS)
 PSS012781|
East Asian Ancestry|
18,751 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias — AUROC: 0.83953 R²: 0.23145 sex, age, array, PCs 1-10 —
PPM037052 PGS018870
(TPMI_280_SBayesR)
 PSS012782|
East Asian Ancestry|
18,751 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias — AUROC: 0.83918 R²: 0.23127 sex, age, array, PCs 1-10 —
PPM037053 PGS018871
(TPMI_280.1_Lassosum2)
 PSS012769|
East Asian Ancestry|
18,736 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias unspecified or not due to blood loss — AUROC: 0.83589 R²: 0.19525 sex, age, array, PCs 1-10 —
PPM037054 PGS018872
(TPMI_280.1_LDpred2)
 PSS012768|
East Asian Ancestry|
18,736 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias unspecified or not due to blood loss — AUROC: 0.83635 R²: 0.1957 sex, age, array, PCs 1-10 —
PPM037055 PGS018873
(TPMI_280.1_MegaPRS)
 PSS012770|
East Asian Ancestry|
18,736 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias unspecified or not due to blood loss — AUROC: 0.83615 R²: 0.19488 sex, age, array, PCs 1-10 —
PPM037056 PGS018874
(TPMI_280.1_PRS-CS)
 PSS012771|
East Asian Ancestry|
18,736 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias unspecified or not due to blood loss — AUROC: 0.8353 R²: 0.19467 sex, age, array, PCs 1-10 —
PPM037057 PGS018875
(TPMI_280.1_SBayesR)
 PSS012772|
East Asian Ancestry|
18,736 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemias unspecified or not due to blood loss — AUROC: 0.83616 R²: 0.19486 sex, age, array, PCs 1-10 —
PPM037058 PGS018876
(TPMI_280.2_Lassosum2)
 PSS012774|
East Asian Ancestry|
18,186 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemia secondary to blood loss chronic — AUROC: 0.8603 R²: 0.04065 sex, age, array, PCs 1-10 —
PPM037059 PGS018877
(TPMI_280.2_LDpred2)
 PSS012773|
East Asian Ancestry|
18,186 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemia secondary to blood loss chronic — AUROC: 0.86153 R²: 0.04101 sex, age, array, PCs 1-10 —
PPM037060 PGS018878
(TPMI_280.2_MegaPRS)
 PSS012775|
East Asian Ancestry|
18,186 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemia secondary to blood loss chronic — AUROC: 0.86199 R²: 0.04118 sex, age, array, PCs 1-10 —
PPM037061 PGS018879
(TPMI_280.2_PRS-CS)
 PSS012776|
East Asian Ancestry|
18,186 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemia secondary to blood loss chronic — AUROC: 0.86146 R²: 0.04077 sex, age, array, PCs 1-10 —
PPM037062 PGS018880
(TPMI_280.2_SBayesR)
 PSS012777|
East Asian Ancestry|
18,186 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Iron deficiency anemia secondary to blood loss chronic — AUROC: 0.85967 R²: 0.04032 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012768 280.1, 280.8, 280.9,D50 —
[
  • 664 cases
  • , 18,072 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012769 280.1, 280.8, 280.9,D50 —
[
  • 664 cases
  • , 18,072 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012770 280.1, 280.8, 280.9,D50 —
[
  • 664 cases
  • , 18,072 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012771 280.1, 280.8, 280.9,D50 —
[
  • 664 cases
  • , 18,072 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012772 280.1, 280.8, 280.9,D50 —
[
  • 664 cases
  • , 18,072 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012773 280.0,D50.0 —
[
  • 114 cases
  • , 18,072 controls
]
,
47.89 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012774 280.0,D50.0 —
[
  • 114 cases
  • , 18,072 controls
]
,
47.89 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012775 280.0,D50.0 —
[
  • 114 cases
  • , 18,072 controls
]
,
47.89 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012776 280.0,D50.0 —
[
  • 114 cases
  • , 18,072 controls
]
,
47.89 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012777 280.0,D50.0 —
[
  • 114 cases
  • , 18,072 controls
]
,
47.89 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012778 280,D50 —
[
  • 679 cases
  • , 18,072 controls
]
,
46.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012779 280,D50 —
[
  • 679 cases
  • , 18,072 controls
]
,
46.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012780 280,D50 —
[
  • 679 cases
  • , 18,072 controls
]
,
46.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012781 280,D50 —
[
  • 679 cases
  • , 18,072 controls
]
,
46.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012782 280,D50 —
[
  • 679 cases
  • , 18,072 controls
]
,
46.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —