Trait: Premature atrial contractions

Trait Information
Identifier HP_0006699
Description A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites.
Trait category
Cardiovascular disease
Synonyms 5 synonyms
  • Atrial ectopic beats
  • Atrial premature complex
  • Ectopic supraventricular rhythms
  • PACs
  • Premature supraventricular beats

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019205
(TPMI_427.6_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 59
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019205/ScoringFiles/PGS019205.txt.gz
PGS019206
(TPMI_427.6_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 292,424
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019206/ScoringFiles/PGS019206.txt.gz
PGS019207
(TPMI_427.6_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 483,932
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019207/ScoringFiles/PGS019207.txt.gz
PGS019208
(TPMI_427.6_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 983,820
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019208/ScoringFiles/PGS019208.txt.gz
PGS019209
(TPMI_427.6_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Premature beats Premature atrial contractions 1,003,465
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019209/ScoringFiles/PGS019209.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037387 PGS019205
(TPMI_427.6_Lassosum2)
 PSS013108|
East Asian Ancestry|
17,752 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Premature beats — AUROC: 0.64974 R²: 0.01001 sex, age, array, PCs 1-10 —
PPM037388 PGS019206
(TPMI_427.6_LDpred2)
 PSS013107|
East Asian Ancestry|
17,752 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Premature beats — AUROC: 0.6484 R²: 0.01008 sex, age, array, PCs 1-10 —
PPM037389 PGS019207
(TPMI_427.6_MegaPRS)
 PSS013109|
East Asian Ancestry|
17,752 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Premature beats — AUROC: 0.64842 R²: 0.01028 sex, age, array, PCs 1-10 —
PPM037390 PGS019208
(TPMI_427.6_PRS-CS)
 PSS013110|
East Asian Ancestry|
17,752 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Premature beats — AUROC: 0.65146 R²: 0.01075 sex, age, array, PCs 1-10 —
PPM037391 PGS019209
(TPMI_427.6_SBayesR)
 PSS013111|
East Asian Ancestry|
17,752 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Premature beats — AUROC: 0.64748 R²: 0.01002 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013107 427.6,I49.1, I49.3, I49.4 —
[
  • 235 cases
  • , 17,517 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013108 427.6,I49.1, I49.3, I49.4 —
[
  • 235 cases
  • , 17,517 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013109 427.6,I49.1, I49.3, I49.4 —
[
  • 235 cases
  • , 17,517 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013110 427.6,I49.1, I49.3, I49.4 —
[
  • 235 cases
  • , 17,517 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013111 427.6,I49.1, I49.3, I49.4 —
[
  • 235 cases
  • , 17,517 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —