Trait: Abnormal circulating sodium concentration

Trait Information
Identifier HP_0010931
Description Any deviation from the normal concentration of sodium in the blood circulation.
Trait category
Other trait
Synonyms 5 synonyms
  • Abnormal blood Na+ levels
  • Abnormal blood sodium concentration
  • Abnormal circulating Na concentration
  • Abnormal sodium(1+) level
  • Abnormality of sodium homeostasis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019757
(TPMI_790.6_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 4
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019757/ScoringFiles/PGS019757.txt.gz
PGS019758
(TPMI_790.6_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 292,919
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019758/ScoringFiles/PGS019758.txt.gz
PGS019759
(TPMI_790.6_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 18,692
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019759/ScoringFiles/PGS019759.txt.gz
PGS019760
(TPMI_790.6_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 983,825
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019760/ScoringFiles/PGS019760.txt.gz
PGS019761
(TPMI_790.6_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 1,071,461
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019761/ScoringFiles/PGS019761.txt.gz
PGS019762
(TPMI_790.6_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other abnormal blood chemistry Abnormal circulating sodium concentration 903,627
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019762/ScoringFiles/PGS019762.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037939 PGS019757
(TPMI_790.6_Lassosum2)
 PSS013655|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65415 R²: 0.03819 sex, age, array, PCs 1-10 —
PPM037940 PGS019758
(TPMI_790.6_LDpred2)
 PSS013654|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65521 R²: 0.03851 sex, age, array, PCs 1-10 —
PPM037941 PGS019759
(TPMI_790.6_MegaPRS)
 PSS013656|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65137 R²: 0.03615 sex, age, array, PCs 1-10 —
PPM037942 PGS019760
(TPMI_790.6_PRS-CS)
 PSS013657|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65431 R²: 0.03809 sex, age, array, PCs 1-10 —
PPM037943 PGS019761
(TPMI_790.6_PRSmix+)
 PSS013658|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65232 R²: 0.03724 sex, age, array, PCs 1-10 —
PPM037944 PGS019762
(TPMI_790.6_SBayesR)
 PSS013659|
East Asian Ancestry|
18,666 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other abnormal blood chemistry — AUROC: 0.65448 R²: 0.03809 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013654 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013655 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013656 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013657 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013658 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013659 790.6,E79.0, R78.71, R78.79, R78.89, R79.0, R79.89, R79.9 —
[
  • 628 cases
  • , 18,038 controls
]
,
45.43 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —