Trait: Sciatica

Trait Information
Identifier HP_0011868
Description Pain in the lower back and hip radiating in the distribution of the sciatic nerve. [PMID: 17872935]
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019732
(TPMI_764_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sciatica Sciatica 1,817
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019732/ScoringFiles/PGS019732.txt.gz
PGS019733
(TPMI_764_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sciatica Sciatica 939,890
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019733/ScoringFiles/PGS019733.txt.gz
PGS019734
(TPMI_764_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sciatica Sciatica 541,283
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019734/ScoringFiles/PGS019734.txt.gz
PGS019735
(TPMI_764_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sciatica Sciatica 983,826
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019735/ScoringFiles/PGS019735.txt.gz
PGS019736
(TPMI_764_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sciatica Sciatica 982,896
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019736/ScoringFiles/PGS019736.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037914 PGS019732
(TPMI_764_Lassosum2)
 PSS013635|
East Asian Ancestry|
19,032 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sciatica — AUROC: 0.61558 R²: 0.01179 sex, age, array, PCs 1-10 —
PPM037915 PGS019733
(TPMI_764_LDpred2)
 PSS013634|
East Asian Ancestry|
19,032 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sciatica — AUROC: 0.61817 R²: 0.01229 sex, age, array, PCs 1-10 —
PPM037916 PGS019734
(TPMI_764_MegaPRS)
 PSS013636|
East Asian Ancestry|
19,032 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sciatica — AUROC: 0.6181 R²: 0.01218 sex, age, array, PCs 1-10 —
PPM037917 PGS019735
(TPMI_764_PRS-CS)
 PSS013637|
East Asian Ancestry|
19,032 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sciatica — AUROC: 0.61932 R²: 0.01236 sex, age, array, PCs 1-10 —
PPM037918 PGS019736
(TPMI_764_SBayesR)
 PSS013638|
East Asian Ancestry|
19,032 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sciatica — AUROC: 0.61924 R²: 0.01226 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013634 724.3,M54.3, M54.4 —
[
  • 254 cases
  • , 18,778 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013635 724.3,M54.3, M54.4 —
[
  • 254 cases
  • , 18,778 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013636 724.3,M54.3, M54.4 —
[
  • 254 cases
  • , 18,778 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013637 724.3,M54.3, M54.4 —
[
  • 254 cases
  • , 18,778 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013638 724.3,M54.3, M54.4 —
[
  • 254 cases
  • , 18,778 controls
]
,
46.3 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —