Trait: Cough

Trait Information
Identifier HP_0012735
Description A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. [PMID: 16428719] [PMID: 17540788]
Trait category
Other trait
Synonyms 2 synonyms
  • Cough
  • Coughing

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019295
(TPMI_512.8_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cough Cough 137,403
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019295/ScoringFiles/PGS019295.txt.gz
PGS019296
(TPMI_512.8_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cough Cough 939,880
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019296/ScoringFiles/PGS019296.txt.gz
PGS019297
(TPMI_512.8_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cough Cough 21,473
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019297/ScoringFiles/PGS019297.txt.gz
PGS019298
(TPMI_512.8_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cough Cough 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019298/ScoringFiles/PGS019298.txt.gz
PGS019299
(TPMI_512.8_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Cough Cough 943,681
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019299/ScoringFiles/PGS019299.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037477 PGS019295
(TPMI_512.8_Lassosum2)
 PSS013198|
East Asian Ancestry|
18,595 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cough — AUROC: 0.61351 R²: 0.06266 sex, age, array, PCs 1-10 —
PPM037478 PGS019296
(TPMI_512.8_LDpred2)
 PSS013197|
East Asian Ancestry|
18,595 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cough — AUROC: 0.61328 R²: 0.063 sex, age, array, PCs 1-10 —
PPM037479 PGS019297
(TPMI_512.8_MegaPRS)
 PSS013199|
East Asian Ancestry|
18,595 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cough — AUROC: 0.6125 R²: 0.0629 sex, age, array, PCs 1-10 —
PPM037480 PGS019298
(TPMI_512.8_PRS-CS)
 PSS013200|
East Asian Ancestry|
18,595 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cough — AUROC: 0.61448 R²: 0.06404 sex, age, array, PCs 1-10 —
PPM037481 PGS019299
(TPMI_512.8_SBayesR)
 PSS013201|
East Asian Ancestry|
18,595 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cough — AUROC: 0.6126 R²: 0.06261 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013197 786.2,R05 —
[
  • 847 cases
  • , 17,748 controls
]
,
46.25 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013198 786.2,R05 —
[
  • 847 cases
  • , 17,748 controls
]
,
46.25 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013199 786.2,R05 —
[
  • 847 cases
  • , 17,748 controls
]
,
46.25 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013200 786.2,R05 —
[
  • 847 cases
  • , 17,748 controls
]
,
46.25 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013201 786.2,R05 —
[
  • 847 cases
  • , 17,748 controls
]
,
46.25 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —