Trait: Parasomnia

Trait Information
Identifier HP_0025234
Description A clinically observable or self-reported abnormal behavior, experience, or physiological event that occurs in association with sleep, specific sleep stages, or sleep-wake transitions. [PMID: 22965264] [PMID: 35956054] [PMID: 40132982]
Trait category
Neurological disorder
Synonym Event that disrupts sleep

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018966
(TPMI_327.5_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Parasomnia Parasomnia 5
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018966/ScoringFiles/PGS018966.txt.gz
PGS018967
(TPMI_327.5_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Parasomnia Parasomnia 939,819
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018967/ScoringFiles/PGS018967.txt.gz
PGS018968
(TPMI_327.5_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Parasomnia Parasomnia 516,575
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018968/ScoringFiles/PGS018968.txt.gz
PGS018969
(TPMI_327.5_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Parasomnia Parasomnia 983,781
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018969/ScoringFiles/PGS018969.txt.gz
PGS018970
(TPMI_327.5_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Parasomnia Parasomnia 1,011,580
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018970/ScoringFiles/PGS018970.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037148 PGS018966
(TPMI_327.5_Lassosum2)
 PSS012874|
East Asian Ancestry|
16,236 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Parasomnia — AUROC: 0.58292 R²: 0.00252 sex, age, array, PCs 1-10 —
PPM037149 PGS018967
(TPMI_327.5_LDpred2)
 PSS012873|
East Asian Ancestry|
16,236 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Parasomnia — AUROC: 0.58298 R²: 0.00251 sex, age, array, PCs 1-10 —
PPM037150 PGS018968
(TPMI_327.5_MegaPRS)
 PSS012875|
East Asian Ancestry|
16,236 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Parasomnia — AUROC: 0.58412 R²: 0.00252 sex, age, array, PCs 1-10 —
PPM037151 PGS018969
(TPMI_327.5_PRS-CS)
 PSS012876|
East Asian Ancestry|
16,236 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Parasomnia — AUROC: 0.58352 R²: 0.00252 sex, age, array, PCs 1-10 —
PPM037152 PGS018970
(TPMI_327.5_SBayesR)
 PSS012877|
East Asian Ancestry|
16,236 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Parasomnia — AUROC: 0.58334 R²: 0.00251 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012873 307.46, 307.47, 307.48, 327.4, 780.56,F51.3, F51.4, F51.5, G47.5 —
[
  • 160 cases
  • , 16,076 controls
]
,
47.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012874 307.46, 307.47, 307.48, 327.4, 780.56,F51.3, F51.4, F51.5, G47.5 —
[
  • 160 cases
  • , 16,076 controls
]
,
47.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012875 307.46, 307.47, 307.48, 327.4, 780.56,F51.3, F51.4, F51.5, G47.5 —
[
  • 160 cases
  • , 16,076 controls
]
,
47.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012876 307.46, 307.47, 307.48, 327.4, 780.56,F51.3, F51.4, F51.5, G47.5 —
[
  • 160 cases
  • , 16,076 controls
]
,
47.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012877 307.46, 307.47, 307.48, 327.4, 780.56,F51.3, F51.4, F51.5, G47.5 —
[
  • 160 cases
  • , 16,076 controls
]
,
47.13 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —