Trait: Impaired glucose tolerance

Trait Information
Identifier HP_0040270
Description An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose.
Trait category
Other trait
Synonyms 2 synonyms
  • Decreased glucose tolerance
  • Glucose tolerance decreased

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018776
(TPMI_250.41_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Impaired fasting glucose Impaired glucose tolerance 785,857
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018776/ScoringFiles/PGS018776.txt.gz
PGS018777
(TPMI_250.41_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Impaired fasting glucose Impaired glucose tolerance 939,845
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018777/ScoringFiles/PGS018777.txt.gz
PGS018778
(TPMI_250.41_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Impaired fasting glucose Impaired glucose tolerance 37,695
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018778/ScoringFiles/PGS018778.txt.gz
PGS018779
(TPMI_250.41_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Impaired fasting glucose Impaired glucose tolerance 983,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018779/ScoringFiles/PGS018779.txt.gz
PGS018780
(TPMI_250.41_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Impaired fasting glucose Impaired glucose tolerance 969,948
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018780/ScoringFiles/PGS018780.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036958 PGS018776
(TPMI_250.41_Lassosum2)
 PSS012656|
East Asian Ancestry|
14,559 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Impaired fasting glucose — AUROC: 0.59688 R²: 0.01582 sex, age, array, PCs 1-10 —
PPM036959 PGS018777
(TPMI_250.41_LDpred2)
 PSS012655|
East Asian Ancestry|
14,559 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Impaired fasting glucose — AUROC: 0.60683 R²: 0.01843 sex, age, array, PCs 1-10 —
PPM036960 PGS018778
(TPMI_250.41_MegaPRS)
 PSS012657|
East Asian Ancestry|
14,559 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Impaired fasting glucose — AUROC: 0.59877 R²: 0.01642 sex, age, array, PCs 1-10 —
PPM036961 PGS018779
(TPMI_250.41_PRS-CS)
 PSS012658|
East Asian Ancestry|
14,559 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Impaired fasting glucose — AUROC: 0.60072 R²: 0.01678 sex, age, array, PCs 1-10 —
PPM036962 PGS018780
(TPMI_250.41_SBayesR)
 PSS012659|
East Asian Ancestry|
14,559 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Impaired fasting glucose — AUROC: 0.60004 R²: 0.0167 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012655 790.21, 790.22,R73.01, R73.02 —
[
  • 553 cases
  • , 14,006 controls
]
,
42.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012656 790.21, 790.22,R73.01, R73.02 —
[
  • 553 cases
  • , 14,006 controls
]
,
42.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012657 790.21, 790.22,R73.01, R73.02 —
[
  • 553 cases
  • , 14,006 controls
]
,
42.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012658 790.21, 790.22,R73.01, R73.02 —
[
  • 553 cases
  • , 14,006 controls
]
,
42.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012659 790.21, 790.22,R73.01, R73.02 —
[
  • 553 cases
  • , 14,006 controls
]
,
42.15 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —