| Trait Information | |
| Identifier | MONDO_0000588 |
| Description | A hypersensitivity reaction type II disease that involves the alimentary part of gastrointestinal system. [MONDO: patterns/location] | Trait category |
Other trait
|
| Synonyms |
3 synonyms
|
| Child trait(s) | 2 child traits |
| Polygenic Score ID & Name | PGS Publication ID (PGP) | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants |
Ancestry distribution GWAS Dev Eval |
Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000021 (GRS1) |
PGP000011 | Oram RA et al. Diabetes Care (2015) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 33 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000021/ScoringFiles/PGS000021.txt.gz | |
| PGS000022 (T1D_GRS) |
PGP000012 | Perry DJ et al. Sci Rep (2018) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 37 | - - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000022/ScoringFiles/PGS000022.txt.gz |
| PGS000023 (AA_GRS) |
PGP000013 | Onengut-Gumuscu S et al. Diabetes Care (2019) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 7 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000023/ScoringFiles/PGS000023.txt.gz |
| PGS000024 (GRS2) |
PGP000014 | Sharp SA et al. Diabetes Care (2019) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 85 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000024/ScoringFiles/PGS000024.txt.gz |
| PGS000040 (GRS_CeD) |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Coeliac disease | celiac disease | 228 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000040/ScoringFiles/PGS000040.txt.gz |
| PGS000041 (GRS-DQ2.5-CeD) |
PGP000029 | Abraham G et al. Genome Med (2015) |
Coeliac disease | celiac disease | 2,513 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000041/ScoringFiles/PGS000041.txt.gz |
| PGS000042 (GRS-DQ2.5-CeD-imputed) |
PGP000029 | Abraham G et al. Genome Med (2015) |
Coeliac disease | celiac disease | 3,317 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000042/ScoringFiles/PGS000042.txt.gz |
| PGS000316 (GRS42_Coeliac) |
PGP000093 | Sharp SA et al. Aliment Pharmacol Ther (2020) |
Coeliac disease | celiac disease | 53 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000316/ScoringFiles/PGS000316.txt.gz | |
| PGS000833 (T1D) |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 66 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000833/ScoringFiles/PGS000833.txt.gz |
| PGS000869 (T1D_48) |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 48 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000869/ScoringFiles/PGS000869.txt.gz |
| PGS001296 (GBE_HC648) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Insulin-dependent diabetes mellitus (time-to-event) | type 1 diabetes mellitus | 356 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001296/ScoringFiles/PGS001296.txt.gz |
| PGS001297 (GBE_HC337) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 69 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001297/ScoringFiles/PGS001297.txt.gz |
| PGS001300 (GBE_BIN21068) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Celiac disease or gluten sensitivity, diagnosed | celiac disease | 9 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001300/ScoringFiles/PGS001300.txt.gz |
| PGS001301 (GBE_HC303) |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Malabsorption/coeliac disease | celiac disease | 428 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001301/ScoringFiles/PGS001301.txt.gz |
| PGS001817 (portability-PLR_250.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 825 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001817/ScoringFiles/PGS001817.txt.gz |
| PGS001856 (portability-PLR_557.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Celiac disease | celiac disease | 1,661 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001856/ScoringFiles/PGS001856.txt.gz |
| PGS001894 (portability-PLR_celiac_gluten) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Diagnosed with coeliac disease or gluten sensitivity | celiac disease | 484 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001894/ScoringFiles/PGS001894.txt.gz |
| PGS002025 (portability-ldpred2_250.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 106,800 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002025/ScoringFiles/PGS002025.txt.gz |
| PGS002067 (portability-ldpred2_557.1) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Celiac disease | celiac disease | 58,231 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002067/ScoringFiles/PGS002067.txt.gz |
| PGS002107 (portability-ldpred2_celiac_gluten) |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Diagnosed with coeliac disease or gluten sensitivity | celiac disease | 39,066 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002107/ScoringFiles/PGS002107.txt.gz |
| PGS003749 (ModelT1D_under25) |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 6,612 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003749/ScoringFiles/PGS003749.txt.gz | |
| PGS003750 (ModelT1D) |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 7,835 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003750/ScoringFiles/PGS003750.txt.gz | |
| PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 63,182 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS003993/ScoringFiles/PGS003993.txt.gz | |
| PGS004009 (lassosum.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 4,031 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004009/ScoringFiles/PGS004009.txt.gz | |
| PGS004020 (lassosum.CV.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 6,682 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004020/ScoringFiles/PGS004020.txt.gz | |
| PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 56,562 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004035/ScoringFiles/PGS004035.txt.gz | |
| PGS004063 (megaprs.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 56,288 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004063/ScoringFiles/PGS004063.txt.gz | |
| PGS004078 (megaprs.CV.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 56,288 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004078/ScoringFiles/PGS004078.txt.gz | |
| PGS004093 (prscs.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 61,651 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004093/ScoringFiles/PGS004093.txt.gz | |
| PGS004102 (prscs.CV.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 61,651 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004102/ScoringFiles/PGS004102.txt.gz | |
| PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 131 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004117/ScoringFiles/PGS004117.txt.gz | |
| PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 354 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004132/ScoringFiles/PGS004132.txt.gz | |
| PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 45,996 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004147/ScoringFiles/PGS004147.txt.gz | |
| PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 62,645 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004162/ScoringFiles/PGS004162.txt.gz | |
| PGS004171 (t1d_1) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 1 diabetes | type 1 diabetes mellitus | 520 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004171/ScoringFiles/PGS004171.txt.gz |
| PGS004172 (t1d_2) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 1 diabetes | type 1 diabetes mellitus | 70 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004172/ScoringFiles/PGS004172.txt.gz |
| PGS004173 (t1d_3) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 1 diabetes | type 1 diabetes mellitus | 295 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004173/ScoringFiles/PGS004173.txt.gz |
| PGS004174 (t1d_4) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 1 diabetes | type 1 diabetes mellitus | 49 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004174/ScoringFiles/PGS004174.txt.gz |
| PGS004175 (t1d_5) |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Type 1 diabetes | type 1 diabetes mellitus | 315 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004175/ScoringFiles/PGS004175.txt.gz |
| PGS004874 (INTERVENE_MegaPRS_T1D) |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 56,916 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004874/ScoringFiles/PGS004874.txt.gz | |
| PGS004930 (celiac_disease_snpnet_combined) |
PGP000665 | Moreno-Grau S et al. Human Genomics (2024) |
Celiac disease | celiac disease | 463 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004930/ScoringFiles/PGS004930.txt.gz |
| PGS005398 (T1D_PRS_combined) |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 645,391 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005398/ScoringFiles/PGS005398.txt.gz |
| PGS005399 (T1D_PRS_male) |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 264,227 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005399/ScoringFiles/PGS005399.txt.gz |
| PGS005400 (T1D_PRS_female) |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 128,279 | - |
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005400/ScoringFiles/PGS005400.txt.gz |
| PGS012555 (TA-PS) |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Type 1 diabetes (T1D) | type 1 diabetes mellitus | 1,116,345 | https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS012555/ScoringFiles/PGS012555.txt.gz |
|
PGS Performance Metric ID (PPM) |
Evaluated Score |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000132 | PGS000021 (GRS1) |
PSS000083| European Ancestry| 2,768 individuals |
PGP000038 | Patel KA et al. Diabetes (2016) |Ext. |
Reported Trait: Type 1 diabetes aetiology (non-monogenic) | — | AUROC: 0.87 [0.86, 0.89] | — | — | Testing the ability of the GRS to discriminate between two sets of cases: - Positive: individuals with type 1 diabetes - Negative: individuals with diabetes and a maturity-onset diabetes of young (MODY) mutation |
| PPM000041 | PGS000021 (GRS1) |
PSS000026| European Ancestry| 223 individuals |
PGP000011 | Oram RA et al. Diabetes Care (2015) |
Reported Trait: Severe insulin deficiency | — | AUROC: 0.96 [0.94, 0.99] | AUROC (without covariates): 0.87 | islet auto-antibody status, body mass index (BMI), age at diagnosis | — |
| PPM000046 | PGS000021 (GRS1) |
PSS000030| African Ancestry| 3,949 individuals |
PGP000013 | Onengut-Gumuscu S et al. Diabetes Care (2019) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.798 | — | — | — |
| PPM000049 | PGS000021 (GRS1) |
PSS000032| European Ancestry| 374,000 individuals |
PGP000014 | Sharp SA et al. Diabetes Care (2019) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.893 | — | — | — |
| PPM023044 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (taking insulin) | — | — | Hazard ratio (HR, high vs low tertile): 1.42 [1.34, 1.51] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023045 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (DKA) | — | — | Hazard ratio (HR, high vs low tertile): 3.28 [2.76, 3.9] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023046 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (Hypoglycemia diagnosis at ED) | — | — | Hazard ratio (HR, high vs low tertile): 1.56 [1.38, 1.77] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023047 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (Outpatient glucose <50 mg/dL) | — | — | Hazard ratio (HR, high vs low tertile): 1.91 [1.76, 2.09] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023048 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (Years to insulin) | — | — | Hazard ratio (HR, high vs low tertile): 0.36 [0.31, 0.42] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023049 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (HbA1c at onset) | — | — | Hazard ratio (HR, high vs low tertile): 1.28 [1.2, 1.37] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023050 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Diabetes outcome (BMI at onset) | — | — | Hazard ratio (HR, high vs low tertile): 0.3 [0.26, 0.36] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023051 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Total cholesterol-HDL | — | — | Hazard ratio (HR, high vs low tertile): 0.17 [0.05, 0.56] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023052 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Chronic kidney disease | — | — | Hazard ratio (HR, high vs low tertile): 1.08 [1.02, 1.15] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM023053 | PGS000021 (GRS1) |
PSS012104| Multi-ancestry (including European)| 109,594 individuals |
PGP000764 | Yang PK et al. Diabetes Care (2024) |Ext. |
Reported Trait: Atrial fibrillation | — | — | Hazard ratio (HR, high vs low tertile): 0.91 [0.84, 0.98] | sex, age, HARE ancestry, and BMI at enrollment | — |
| PPM030709 | PGS000021 (GRS1) |
PSS012260| European Ancestry| 158 individuals |
PGP000807 | Davis TME et al. Intern Med J (2024) |Ext. |
Reported Trait: Type 1 diabetes vs latent autoimmune diabetes/type 2 diabetes | — | AUROC: 0.662 [0.567, 0.756] | — | — | — |
| PPM000042 | PGS000022 (T1D_GRS) |
PSS000029| European Ancestry| 1,447 individuals |
PGP000012 | Perry DJ et al. Sci Rep (2018) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.8508 | — | — | AUROCs are reported with respect to unrelated-control samples |
| PPM000043 | PGS000022 (T1D_GRS) |
PSS000028| Hispanic or Latin American Ancestry| 252 individuals |
PGP000012 | Perry DJ et al. Sci Rep (2018) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.9003 | — | — | AUROCs are reported with respect to unrelated-control samples |
| PPM000044 | PGS000022 (T1D_GRS) |
PSS000027| African Ancestry| 299 individuals |
PGP000012 | Perry DJ et al. Sci Rep (2018) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.7522 | — | — | AUROCs are reported with respect to unrelated-control samples |
| PPM000045 | PGS000023 (AA_GRS) |
PSS000030| African Ancestry| 3,949 individuals |
PGP000013 | Onengut-Gumuscu S et al. Diabetes Care (2019) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.87 | — | — | NOTE: Evaluated using cross-validation on training samples (20% heldout, 1000 iterations) |
| PPM000047 | PGS000023 (AA_GRS) |
PSS000031| African Ancestry| 145 individuals |
PGP000013 | Onengut-Gumuscu S et al. Diabetes Care (2019) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.779 | — | — | — |
| PPM018536 | PGS000023 (AA_GRS) |
PSS011012| Multi-ancestry (including European)| 39,820 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.781 | — | — | — |
| PPM018537 | PGS000023 (AA_GRS) |
PSS011009| Multi-ancestry (including European)| 57,643 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.817 | — | — | — |
| PPM018539 | PGS000023 (AA_GRS) |
PSS011011| European Ancestry| 16,663 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 97.0 % PPV (reference): 86.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM018541 | PGS000023 (AA_GRS) |
PSS011010| Multi-ancestry (excluding European)| 40,980 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 86.0 % PPV (reference): 71.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM018543 | PGS000023 (AA_GRS) |
PSS011013| Multi-ancestry (excluding European)| 4,881 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 83.0 % PPV (reference): 53.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM021725 | PGS000023 (AA_GRS) |
PSS011762| European Ancestry| 8,417 individuals |
PGP000665 | Moreno-Grau S et al. Human Genomics (2024) |Ext. |
Reported Trait: Type 1 diabetes mellitus | OR: 2.31 [2.0, 2.68] | AUROC: 0.77 | — | — | — |
| PPM000048 | PGS000024 (GRS2) |
PSS000032| European Ancestry| 374,000 individuals |
PGP000014 | Sharp SA et al. Diabetes Care (2019) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.921 | Youden index: 0.698 | — | — |
| PPM000753 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (5 years horizon time; landmark age 2 years) | — | AUROC: 0.93 | — | autoantibodies, family history | — |
| PPM000754 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (8 years horizon time; landmark age 2 years) | — | AUROC: 0.87 | — | autoantibodies, family history | — |
| PPM000755 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (5 years horizon time; landmark age 4 years) | — | AUROC: 0.96 | — | autoantibodies, family history | — |
| PPM000751 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (1 year horizon time; landmark age 2 years) | — | AUROC: 0.96 | — | autoantibodies, family history | — |
| PPM000752 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (3 years horizon time; landmark age 2 years) | — | AUROC: 0.94 | — | autoantibodies, family history | — |
| PPM000750 | PGS000024 (GRS2) |
PSS000368| Ancestry Not Reported| 7,798 individuals |
PGP000091 | Ferrat LA et al. Nat Med (2020) |Ext. |
Reported Trait: Type 1 diabetes (by age 8; landmark age 2 years) | — | AUROC: 0.73 [0.7, 0.77] | — | — | — |
| PPM002249 | PGS000024 (GRS2) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |Ext. |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.0 [0.93, 1.07] | — | — | PC1-10 | 8 proxy variants were used to evaluate this score |
| PPM002250 | PGS000024 (GRS2) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |Ext. |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.0 [0.93, 1.07] | — | — | PC1-10 | 8 proxy variants were used to evaluate this score |
| PPM002251 | PGS000024 (GRS2) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |Ext. |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.01 [0.95, 1.08] | — | — | PC1-10 | 8 proxy variants were used to evaluate this score |
| PPM002252 | PGS000024 (GRS2) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |Ext. |
Reported Trait: Moderate Age-Related Diabetes | OR: 0.99 [0.94, 1.04] | — | — | PC1-10 | 8 proxy variants were used to evaluate this score |
| PPM002248 | PGS000024 (GRS2) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |Ext. |
Reported Trait: Severe Autoimmune Diabetes | OR: 2.55 [2.28, 2.86] | — | — | PC1-10 | 8 proxy variants were used to evaluate this score |
| PPM014801 | PGS000024 (GRS2) |
PSS009895| European Ancestry| 1,168 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.864 [0.823, 0.905] | — | — | — |
| PPM014803 | PGS000024 (GRS2) |
PSS009893| African Ancestry| 366 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.851 [0.805, 0.897] | — | — | — |
| PPM014805 | PGS000024 (GRS2) |
PSS009894| Hispanic or Latin American Ancestry| 412 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.935 [0.906, 0.964] | — | — | — |
| PPM014807 | PGS000024 (GRS2) |
PSS009896| Ancestry Not Reported| 99 individuals |
PGP000338 | Oram RA et al. Diabetes Care (2022) |Ext. |
Reported Trait: Diabetes autoantibody positive insulin sensitive | — | AUROC: 0.79 [0.679, 0.902] | — | — | — |
| PPM018532 | PGS000024 (GRS2) |
PSS011012| Multi-ancestry (including European)| 39,820 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.875 | — | — | — |
| PPM018533 | PGS000024 (GRS2) |
PSS011009| Multi-ancestry (including European)| 57,643 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.822 | — | — | — |
| PPM018534 | PGS000024 (GRS2) |
PSS011014| European Ancestry| 34,939 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.888 | — | — | — |
| PPM018535 | PGS000024 (GRS2) |
PSS011014| European Ancestry| 34,939 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | AUROC: 0.858 | — | — | — |
| PPM018538 | PGS000024 (GRS2) |
PSS011011| European Ancestry| 16,663 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 100.0 % PPV (reference): 86.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM018540 | PGS000024 (GRS2) |
PSS011010| Multi-ancestry (excluding European)| 40,980 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 93.0 % PPV (reference): 71.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM018542 | PGS000024 (GRS2) |
PSS011014| European Ancestry| 34,939 individuals |
PGP000477 | Deutsch AJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes | — | — | PPV (+PRS): 97.0 % PPV (reference): 71.0 % |
eMERGE type 1 diabetes algorithm | — |
| PPM020098 | PGS000024 (GRS2) |
PSS011295| Ancestry Not Reported| 1,798 individuals |
PGP000519 | Thomas NJ et al. Diabetes Care (2023) |Ext. |
Reported Trait: Type 1 diabetes vs autoantibody negative T2D | — | — | p-value (inferior to): 0.0001 | — | — |
| PPM021124 | PGS000024 (GRS2) |
PSS011531| European Ancestry| 9,465 individuals |
PGP000614 | Qu HQ et al. Diabetes Obes Metab (2021) |Ext. |
Reported Trait: Type 1 diabetes | β: -0.22 | AUROC: 0.87 | — | — | — |
| PPM021125 | PGS000024 (GRS2) |
PSS011532| European Ancestry| 9,450 individuals |
PGP000614 | Qu HQ et al. Diabetes Obes Metab (2021) |Ext. |
Reported Trait: Type 1 diabetes | β: -0.234 | AUROC: 0.862 | — | — | — |
| PPM000093 | PGS000040 (GRS_CeD) |
PSS000059| European Ancestry| 2,476 individuals |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Reported Trait: Coeliac disease | — | AUROC: 0.9 | — | — | — |
| PPM000094 | PGS000040 (GRS_CeD) |
PSS000061| European Ancestry| 1,040 individuals |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Reported Trait: Coeliac disease | — | AUROC: 0.87 | — | — | — |
| PPM000095 | PGS000040 (GRS_CeD) |
PSS000062| European Ancestry| 1,649 individuals |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Reported Trait: Coeliac disease | — | AUROC: 0.86 | — | — | — |
| PPM000096 | PGS000040 (GRS_CeD) |
PSS000063| European Ancestry| 2,200 individuals |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Reported Trait: Coeliac disease | — | AUROC: 0.87 | — | — | — |
| PPM000097 | PGS000040 (GRS_CeD) |
PSS000060| European Ancestry| 10,304 individuals |
PGP000028 | Abraham G et al. PLoS Genet (2014) |
Reported Trait: Coeliac disease | — | AUROC: 0.87 | — | — | — |
| PPM000098 | PGS000040 (GRS_CeD) |
PSS000064| European Ancestry| 1,696 individuals |
PGP000029 | Abraham G et al. Genome Med (2015) |Ext. |
Reported Trait: Coeliac disease | — | AUROC: 0.831 [0.808, 0.85] | — | — | — |
| PPM000099 | PGS000040 (GRS_CeD) |
PSS000065| European Ancestry| 1,237 individuals |
PGP000029 | Abraham G et al. Genome Med (2015) |Ext. |
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers | — | AUROC: 0.669 [0.625, 0.713] | — | — | — |
| PPM000100 | PGS000041 (GRS-DQ2.5-CeD) |
PSS000065| European Ancestry| 1,237 individuals |
PGP000029 | Abraham G et al. Genome Med (2015) |
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers | — | AUROC: 0.718 [0.676, 0.761] | — | — | — |
| PPM000101 | PGS000042 (GRS-DQ2.5-CeD-imputed) |
PSS000065| European Ancestry| 1,237 individuals |
PGP000029 | Abraham G et al. Genome Med (2015) |
Reported Trait: Coeliac disease in HLA-DQ2.5 carriers | — | AUROC: 0.73 [0.687, 0.772] | — | — | — |
| PPM000805 | PGS000316 (GRS42_Coeliac) |
PSS000381| Ancestry Not Reported| 154 individuals |
PGP000093 | Sharp SA et al. Aliment Pharmacol Ther (2020) |
Reported Trait: Coeliac disease | — | AUROC: 0.835 [0.76, 0.911] | — | — | — |
| PPM000804 | PGS000316 (GRS42_Coeliac) |
PSS000382| European Ancestry| 379,767 individuals |
PGP000093 | Sharp SA et al. Aliment Pharmacol Ther (2020) |
Reported Trait: Coeliac disease | — | AUROC: 0.879 [0.87, 0.888] | — | — | — |
| PPM002243 | PGS000833 (T1D) |
PSS001086| European Ancestry| 3,194 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Autoimmune Diabetes | OR: 1.39 [1.25, 1.54] | — | — | PC1-10 | — |
| PPM002246 | PGS000833 (T1D) |
PSS001085| European Ancestry| 4,116 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Obesity-related Diabetes | OR: 1.04 [0.97, 1.11] | — | — | PC1-10 | — |
| PPM002247 | PGS000833 (T1D) |
PSS001084| European Ancestry| 5,597 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Moderate Age-Related Diabetes | OR: 1.02 [0.97, 1.07] | — | — | PC1-10 | — |
| PPM002244 | PGS000833 (T1D) |
PSS001087| European Ancestry| 3,930 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Deficient Diabetes | OR: 1.01 [0.94, 1.08] | — | — | PC1-10 | — |
| PPM002245 | PGS000833 (T1D) |
PSS001088| European Ancestry| 3,869 individuals |
PGP000211 | Aly DM et al. Nat Genet (2021) |
Reported Trait: Severe Insulin-Resistant Diabetes | OR: 1.03 [0.96, 1.11] | — | — | PC1-10 | — |
| PPM002414 | PGS000869 (T1D_48) |
PSS001092| Ancestry Not Reported| 5,740 individuals |
PGP000214 | Aksit MA et al. J Clin Endocrinol Metab (2020) |
Reported Trait: Cystic-fibrosis related diabetes | HR: 1.077 | — | — | PCs(1-4), site of recruitment | — |
| PPM008978 | PGS001296 (GBE_HC648) |
PSS004570| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE insulin-dependent diabetes mellitus | — | AUROC: 0.66885 [0.62172, 0.71599] | R²: 0.04054 Incremental AUROC (full-covars): -0.01128 PGS R2 (no covariates): 0.00021 PGS AUROC (no covariates): 0.51906 [0.4689, 0.56923] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008979 | PGS001296 (GBE_HC648) |
PSS004571| East Asian Ancestry| 1,704 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE insulin-dependent diabetes mellitus | — | AUROC: 0.89264 [0.80447, 0.98081] | R²: 0.19006 Incremental AUROC (full-covars): -0.01413 PGS R2 (no covariates): 0.00422 PGS AUROC (no covariates): 0.43531 [0.15162, 0.71901] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008980 | PGS001296 (GBE_HC648) |
PSS004572| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE insulin-dependent diabetes mellitus | — | AUROC: 0.70536 [0.66494, 0.74577] | R²: 0.0607 Incremental AUROC (full-covars): 0.12077 PGS R2 (no covariates): 0.05496 PGS AUROC (no covariates): 0.68941 [0.64672, 0.73209] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008981 | PGS001296 (GBE_HC648) |
PSS004573| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE insulin-dependent diabetes mellitus | — | AUROC: 0.67679 [0.6379, 0.71568] | R²: 0.04266 Incremental AUROC (full-covars): -0.01593 PGS R2 (no covariates): 0.0016 PGS AUROC (no covariates): 0.54249 [0.49552, 0.58946] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008982 | PGS001296 (GBE_HC648) |
PSS004574| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: TTE insulin-dependent diabetes mellitus | — | AUROC: 0.65986 [0.63673, 0.68299] | R²: 0.03385 Incremental AUROC (full-covars): 0.06785 PGS R2 (no covariates): 0.02496 PGS AUROC (no covariates): 0.62694 [0.60131, 0.65256] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008983 | PGS001297 (GBE_HC337) |
PSS004457| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.78146 [0.64554, 0.91738] | R²: 0.08635 Incremental AUROC (full-covars): -0.05504 PGS R2 (no covariates): 0.00185 PGS AUROC (no covariates): 0.41884 [0.19064, 0.64704] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008984 | PGS001297 (GBE_HC337) |
PSS004458| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.79737 [0.708, 0.88674] | R²: 0.11683 Incremental AUROC (full-covars): 0.09636 PGS R2 (no covariates): 0.0912 PGS AUROC (no covariates): 0.77118 [0.67108, 0.87128] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008985 | PGS001297 (GBE_HC337) |
PSS004459| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.81031 [0.66359, 0.95703] | R²: 0.06825 Incremental AUROC (full-covars): -0.01908 PGS R2 (no covariates): 6e-05 PGS AUROC (no covariates): 0.53853 [0.37761, 0.69945] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008986 | PGS001297 (GBE_HC337) |
PSS004460| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.7643 [0.7041, 0.8245] | R²: 0.06625 Incremental AUROC (full-covars): 0.19149 PGS R2 (no covariates): 0.06103 PGS AUROC (no covariates): 0.76543 [0.70744, 0.82342] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008997 | PGS001300 (GBE_BIN21068) |
PSS003667| African Ancestry| 969 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | AUROC: 0.77521 [0.67165, 0.87877] | R²: 0.10494 Incremental AUROC (full-covars): 0.00391 PGS R2 (no covariates): 0.00465 PGS AUROC (no covariates): 0.54048 [0.39518, 0.68579] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008998 | PGS001300 (GBE_BIN21068) |
PSS003668| European Ancestry| 9,024 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | AUROC: 0.67118 [0.63561, 0.70676] | R²: 0.04801 Incremental AUROC (full-covars): 0.03638 PGS R2 (no covariates): 0.02217 PGS AUROC (no covariates): 0.58541 [0.54195, 0.62888] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM008999 | PGS001300 (GBE_BIN21068) |
PSS003669| South Asian Ancestry| 1,145 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | AUROC: 0.78803 [0.69728, 0.87878] | R²: 0.09336 Incremental AUROC (full-covars): 0.00365 PGS R2 (no covariates): 0.00127 PGS AUROC (no covariates): 0.56184 [0.43287, 0.6908] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009000 | PGS001300 (GBE_BIN21068) |
PSS003670| European Ancestry| 24,310 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | AUROC: 0.6734 [0.64935, 0.69745] | R²: 0.04185 Incremental AUROC (full-covars): 0.08398 PGS R2 (no covariates): 0.02957 PGS AUROC (no covariates): 0.62888 [0.60094, 0.65683] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009001 | PGS001301 (GBE_HC303) |
PSS004423| African Ancestry| 6,497 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Malabsorption/coeliac disease | — | AUROC: 0.84259 [0.73437, 0.95081] | R²: 0.12308 Incremental AUROC (full-covars): 0.02463 PGS R2 (no covariates): 0.03018 PGS AUROC (no covariates): 0.68151 [0.48835, 0.87467] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009002 | PGS001301 (GBE_HC303) |
PSS004424| European Ancestry| 24,905 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Malabsorption/coeliac disease | — | AUROC: 0.81472 [0.7798, 0.84965] | R²: 0.15108 Incremental AUROC (full-covars): 0.1791 PGS R2 (no covariates): 0.14221 PGS AUROC (no covariates): 0.80994 [0.77441, 0.84547] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009003 | PGS001301 (GBE_HC303) |
PSS004425| South Asian Ancestry| 7,831 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Malabsorption/coeliac disease | — | AUROC: 0.81699 [0.73267, 0.9013] | R²: 0.11397 Incremental AUROC (full-covars): 0.06035 PGS R2 (no covariates): 0.07098 PGS AUROC (no covariates): 0.76239 [0.65258, 0.87221] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009004 | PGS001301 (GBE_HC303) |
PSS004426| European Ancestry| 67,425 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Malabsorption/coeliac disease | — | AUROC: 0.83351 [0.81372, 0.85329] | R²: 0.14905 Incremental AUROC (full-covars): 0.25775 PGS R2 (no covariates): 0.14224 PGS AUROC (no covariates): 0.82867 [0.80826, 0.84908] |
age, sex, UKB array type, Genotype PCs | Full Model & PGS R2 is estimated using Nagelkerke's method |
| PPM009436 | PGS001817 (portability-PLR_250.1) |
PSS009287| European Ancestry| 18,975 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0752 [0.061, 0.0893] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009437 | PGS001817 (portability-PLR_250.1) |
PSS009061| European Ancestry| 3,954 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0684 [0.0372, 0.0994] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009438 | PGS001817 (portability-PLR_250.1) |
PSS008615| European Ancestry| 6,300 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0739 [0.0493, 0.0985] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009439 | PGS001817 (portability-PLR_250.1) |
PSS008391| Greater Middle Eastern Ancestry| 1,107 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0349 [-0.0246, 0.0941] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009440 | PGS001817 (portability-PLR_250.1) |
PSS008169| South Asian Ancestry| 5,228 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0224 [-0.0047, 0.0496] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009441 | PGS001817 (portability-PLR_250.1) |
PSS007956| East Asian Ancestry| 1,729 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): -0.0001 [-0.0475, 0.0474] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009442 | PGS001817 (portability-PLR_250.1) |
PSS007737| African Ancestry| 2,200 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): -0.0006 [-0.0426, 0.0414] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009443 | PGS001817 (portability-PLR_250.1) |
PSS008840| African Ancestry| 3,490 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): -0.0187 [-0.052, 0.0146] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009738 | PGS001856 (portability-PLR_557.1) |
PSS009331| European Ancestry| 16,106 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.1196 [0.1043, 0.1348] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009739 | PGS001856 (portability-PLR_557.1) |
PSS009105| European Ancestry| 3,509 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0779 [0.0448, 0.1108] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009740 | PGS001856 (portability-PLR_557.1) |
PSS008659| European Ancestry| 5,445 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.097 [0.0706, 0.1233] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009741 | PGS001856 (portability-PLR_557.1) |
PSS008433| Greater Middle Eastern Ancestry| 998 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0652 [0.0025, 0.1273] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009742 | PGS001856 (portability-PLR_557.1) |
PSS008213| South Asian Ancestry| 5,277 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0535 [0.0265, 0.0805] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009743 | PGS001856 (portability-PLR_557.1) |
PSS007778| African Ancestry| 2,091 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0261 [-0.017, 0.0691] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM009744 | PGS001856 (portability-PLR_557.1) |
PSS008882| African Ancestry| 3,455 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.028 [-0.0054, 0.0614] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010037 | PGS001894 (portability-PLR_celiac_gluten) |
PSS009164| European Ancestry| 1,354 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0796 [0.026, 0.1327] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010038 | PGS001894 (portability-PLR_celiac_gluten) |
PSS008718| European Ancestry| 2,442 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0358 [-0.0041, 0.0755] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010039 | PGS001894 (portability-PLR_celiac_gluten) |
PSS008492| Greater Middle Eastern Ancestry| 208 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0295 [-0.1141, 0.1719] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010040 | PGS001894 (portability-PLR_celiac_gluten) |
PSS008270| South Asian Ancestry| 908 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0219 [-0.0439, 0.0876] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010041 | PGS001894 (portability-PLR_celiac_gluten) |
PSS007834| African Ancestry| 400 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): -0.0127 [-0.1132, 0.088] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010042 | PGS001894 (portability-PLR_celiac_gluten) |
PSS008938| African Ancestry| 526 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0162 [-0.0711, 0.1032] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM010036 | PGS001894 (portability-PLR_celiac_gluten) |
PSS009390| European Ancestry| 7,142 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0993 [0.0763, 0.1223] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011074 | PGS002025 (portability-ldpred2_250.1) |
PSS009287| European Ancestry| 18,975 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0824 [0.0682, 0.0965] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011075 | PGS002025 (portability-ldpred2_250.1) |
PSS009061| European Ancestry| 3,954 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0666 [0.0354, 0.0976] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011076 | PGS002025 (portability-ldpred2_250.1) |
PSS008615| European Ancestry| 6,300 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0719 [0.0472, 0.0964] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011077 | PGS002025 (portability-ldpred2_250.1) |
PSS008391| Greater Middle Eastern Ancestry| 1,107 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0529 [-0.0066, 0.112] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011078 | PGS002025 (portability-ldpred2_250.1) |
PSS008169| South Asian Ancestry| 5,228 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0228 [-0.0044, 0.0499] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011079 | PGS002025 (portability-ldpred2_250.1) |
PSS007956| East Asian Ancestry| 1,729 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): -0.0048 [-0.0522, 0.0427] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011080 | PGS002025 (portability-ldpred2_250.1) |
PSS007737| African Ancestry| 2,200 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): 0.0089 [-0.0331, 0.0509] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011081 | PGS002025 (portability-ldpred2_250.1) |
PSS008840| African Ancestry| 3,490 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Type 1 diabetes | — | — | Partial Correlation (partial-r): -0.013 [-0.0463, 0.0203] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011398 | PGS002067 (portability-ldpred2_557.1) |
PSS009331| European Ancestry| 16,106 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.1241 [0.1088, 0.1393] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011400 | PGS002067 (portability-ldpred2_557.1) |
PSS008659| European Ancestry| 5,445 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0979 [0.0714, 0.1242] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011401 | PGS002067 (portability-ldpred2_557.1) |
PSS008433| Greater Middle Eastern Ancestry| 998 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0718 [0.0092, 0.1339] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011402 | PGS002067 (portability-ldpred2_557.1) |
PSS008213| South Asian Ancestry| 5,277 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0512 [0.0242, 0.0781] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011403 | PGS002067 (portability-ldpred2_557.1) |
PSS007778| African Ancestry| 2,091 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0094 [-0.0337, 0.0525] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011404 | PGS002067 (portability-ldpred2_557.1) |
PSS008882| African Ancestry| 3,455 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0241 [-0.0093, 0.0575] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011399 | PGS002067 (portability-ldpred2_557.1) |
PSS009105| European Ancestry| 3,509 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Celiac disease | — | — | Partial Correlation (partial-r): 0.0695 [0.0364, 0.1024] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011712 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS009390| European Ancestry| 7,142 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0964 [0.0733, 0.1193] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011713 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS009164| European Ancestry| 1,354 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0848 [0.0313, 0.1379] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011714 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS008718| European Ancestry| 2,442 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.041 [0.0012, 0.0807] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011715 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS008492| Greater Middle Eastern Ancestry| 208 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0206 [-0.1229, 0.1632] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011716 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS008270| South Asian Ancestry| 908 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0237 [-0.0422, 0.0893] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011717 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS007834| African Ancestry| 400 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): -0.0242 [-0.1245, 0.0766] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM011718 | PGS002107 (portability-ldpred2_celiac_gluten) |
PSS008938| African Ancestry| 526 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Diagnosed with coeliac disease or gluten sensitivity | — | — | Partial Correlation (partial-r): 0.0172 [-0.0701, 0.1042] | sex, age, birth date, deprivation index, 16 PCs | — |
| PPM018508 | PGS003749 (ModelT1D_under25) |
PSS011001| European Ancestry| 119,273 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Type 1 diabetes with age of diagnosis under 25 | — | AUROC: 0.797 | Nagelkerke R2: 0.099 | — | — |
| PPM018512 | PGS003749 (ModelT1D_under25) |
PSS011000| European Ancestry| 7,067 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Discrimination of Type 1 diabetes from Type 2 diabetes | — | AUROC: 0.792 | — | — | — |
| PPM018514 | PGS003749 (ModelT1D_under25) |
PSS010998| European Ancestry| 2,494 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Discrimination of Type 1 diabetes from Type 2 diabetes | — | AUROC: 0.686 | — | — | — |
| PPM018509 | PGS003750 (ModelT1D) |
PSS010999| European Ancestry| 120,028 individuals |
PGP000472 | Shoaib M et al. Genet Epidemiol (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.64 | Nagelkerke R2: 0.014 | — | — |
| PPM019950 | PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.95715 [1.81292462, 2.11285989] β: 0.67149 [0.59494135, 0.74804243] |
AUROC: 0.6973 [0.67432957, 0.72027485] | R²: 0.06925 [0.05366269, 0.08783238] | 0 | beta = log(or)/sd_pgs |
| PPM019951 | PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.37817 [2.30792027, 2.45056467] β: 0.86633 [0.8363468, 0.89631847] |
AUROC: 0.73364 [0.7261439, 0.74113326] | R²: 0.08844 [0.08240615, 0.09429924] | 0 | beta = log(or)/sd_pgs |
| PPM019952 | PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.02806 [0.93617919, 1.12896592] β: 0.02768 [-0.0659484, 0.1213021] |
AUROC: 0.49306 [0.46664532, 0.51946756] | R²: 0.00011 [0.0, 0.00201222] | 0 | beta = log(or)/sd_pgs |
| PPM019953 | PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.35954 [1.23424263, 1.49756477] β: 0.30715 [0.21045753, 0.4038403] |
AUROC: 0.58092 [0.55093059, 0.61090482] | R²: 0.01115 [0.00472683, 0.02038956] | 0 | beta = log(or)/sd_pgs |
| PPM019954 | PGS003993 (dbslmm.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.40714 [2.12613109, 2.72529613] β: 0.87844 [0.75430394, 1.0025771] |
AUROC: 0.7438 [0.70604081, 0.78155137] | R²: 0.11521 [0.08261093, 0.15365125] | 0 | beta = log(or)/sd_pgs |
| PPM019995 | PGS004009 (lassosum.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.95016 [1.8039695, 2.10819938] β: 0.66791 [0.58998952, 0.74583421] |
AUROC: 0.69542 [0.67251261, 0.71833611] | R²: 0.06635 [0.05145834, 0.08404252] | 0 | beta = log(or)/sd_pgs |
| PPM019996 | PGS004009 (lassosum.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.41964 [2.34758401, 2.49390831] β: 0.88362 [0.85338672, 0.91385108] |
AUROC: 0.73427 [0.72674347, 0.74178811] | R²: 0.09058 [0.08466118, 0.09688729] | 0 | beta = log(or)/sd_pgs |
| PPM019997 | PGS004009 (lassosum.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.02716 [0.9355068, 1.12778739] β: 0.0268 [-0.0666669, 0.12025765] |
AUROC: 0.51065 [0.48423163, 0.53706706] | R²: 0.0001 [0.0, 0.0020518] | 0 | beta = log(or)/sd_pgs |
| PPM019998 | PGS004009 (lassosum.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.41112 [1.28181566, 1.55346498] β: 0.34438 [0.24827756, 0.44048791] |
AUROC: 0.58719 [0.55730466, 0.61706811] | R²: 0.01421 [0.00653265, 0.0245434] | 0 | beta = log(or)/sd_pgs |
| PPM019999 | PGS004009 (lassosum.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.32891 [2.05474726, 2.63965287] β: 0.8454 [0.72015285, 0.97064742] |
AUROC: 0.74138 [0.70575103, 0.77699909] | R²: 0.10551 [0.07498107, 0.14145494] | 0 | beta = log(or)/sd_pgs |
| PPM019990 | PGS004020 (lassosum.CV.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.96291 [1.8158394, 2.12190093] β: 0.67443 [0.59654784, 0.75231235] |
AUROC: 0.69707 [0.6741702, 0.71996442] | R²: 0.06768 [0.05283665, 0.08590187] | 0 | beta = log(or)/sd_pgs |
| PPM019991 | PGS004020 (lassosum.CV.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.44728 [2.37432767, 2.52248258] β: 0.89498 [0.86471431, 0.92524357] |
AUROC: 0.73762 [0.73014965, 0.74509755] | R²: 0.0929 [0.08697873, 0.09927932] | 0 | beta = log(or)/sd_pgs |
| PPM019992 | PGS004020 (lassosum.CV.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.02458 [0.93312347, 1.12499983] β: 0.02428 [-0.0692177, 0.11778288] |
AUROC: 0.51003 [0.4834716, 0.5365786] | R²: 8e-05 [0.0, 0.00192444] | 0 | beta = log(or)/sd_pgs |
| PPM019993 | PGS004020 (lassosum.CV.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.42499 [1.29448907, 1.56865336] β: 0.35417 [0.25811607, 0.45021752] |
AUROC: 0.59001 [0.56010026, 0.61992271] | R²: 0.01505 [0.00716292, 0.02582298] | 0 | beta = log(or)/sd_pgs |
| PPM019994 | PGS004020 (lassosum.CV.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.34601 [2.07012734, 2.65865075] β: 0.85271 [0.72761012, 0.97781876] |
AUROC: 0.7445 [0.70912362, 0.7798788] | R²: 0.10752 [0.07728308, 0.14325004] | 0 | beta = log(or)/sd_pgs |
| PPM019965 | PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.32281 [2.13168407, 2.53107946] β: 0.84278 [0.75691231, 0.92864588] |
AUROC: 0.71195 [0.68696399, 0.73694375] | R²: 0.0847 [0.06629693, 0.10703174] | 0 | beta = log(or)/sd_pgs |
| PPM019966 | PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.04799 [1.98592622, 2.11200077] β: 0.71686 [0.68608541, 0.74763573] |
AUROC: 0.69176 [0.68386243, 0.69965429] | R²: 0.05646 [0.05209086, 0.06140139] | 0 | beta = log(or)/sd_pgs |
| PPM019967 | PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.00124 [0.9117887, 1.09947388] β: 0.00124 [-0.092347, 0.09483178] |
AUROC: 0.50968 [0.48325371, 0.53611056] | R²: 2.13e-07 [0.0, 0.00104871] | 0 | beta = log(or)/sd_pgs |
| PPM019968 | PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.41811 [1.28793383, 1.56143556] β: 0.34932 [0.25303925, 0.44560563] |
AUROC: 0.5837 [0.55391495, 0.61347751] | R²: 0.01451 [0.00709685, 0.02594541] | 0 | beta = log(or)/sd_pgs |
| PPM019969 | PGS004035 (ldpred2.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.67223 [2.33127749, 3.06303713] β: 0.98291 [0.8464164, 1.11940695] |
AUROC: 0.74858 [0.71080109, 0.78636453] | R²: 0.11349 [0.08057329, 0.1513995] | 0 | beta = log(or)/sd_pgs |
| PPM019970 | PGS004063 (megaprs.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.96796 [1.8152611, 2.13351315] β: 0.677 [0.59622931, 0.75776999] |
AUROC: 0.68845 [0.66493994, 0.71195684] | R²: 0.06145 [0.0466906, 0.07846122] | 0 | beta = log(or)/sd_pgs |
| PPM019971 | PGS004063 (megaprs.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.98877 [1.93780812, 2.04107353] β: 0.68752 [0.6615575, 0.71347591] |
AUROC: 0.71357 [0.70595937, 0.72117434] | R²: 0.0733 [0.06778529, 0.07934817] | 0 | beta = log(or)/sd_pgs |
| PPM019972 | PGS004063 (megaprs.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 0.99583 [0.90679351, 1.09360849] β: -0.00418 [-0.0978405, 0.08948277] |
AUROC: 0.50552 [0.47751517, 0.53351676] | R²: 2.41e-06 [0.0, 0.00132293] | 0 | beta = log(or)/sd_pgs |
| PPM019973 | PGS004063 (megaprs.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.34209 [1.2160386, 1.48119754] β: 0.29422 [0.19559853, 0.39285091] |
AUROC: 0.57505 [0.54588165, 0.60422019] | R²: 0.00983 [0.00444222, 0.01812082] | 0 | beta = log(or)/sd_pgs |
| PPM019974 | PGS004063 (megaprs.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.32027 [2.05513583, 2.61961025] β: 0.84168 [0.72034195, 0.96302555] |
AUROC: 0.73583 [0.6992247, 0.77242674] | R²: 0.10657 [0.0731231, 0.14722601] | 0 | beta = log(or)/sd_pgs |
| PPM019975 | PGS004078 (megaprs.CV.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.10311 [1.93487496, 2.28597324] β: 0.74342 [0.6600427, 0.82679186] |
AUROC: 0.69475 [0.67006258, 0.71942771] | R²: 0.06975 [0.05276804, 0.08919338] | 0 | beta = log(or)/sd_pgs |
| PPM019976 | PGS004078 (megaprs.CV.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.14067 [2.07613635, 2.20720948] β: 0.76112 [0.73050864, 0.79172904] |
AUROC: 0.70513 [0.69736383, 0.71288732] | R²: 0.06481 [0.059934, 0.06970825] | 0 | beta = log(or)/sd_pgs |
| PPM019977 | PGS004078 (megaprs.CV.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.00042 [0.91103711, 1.09857896] β: 0.00042 [-0.0931716, 0.09401749] |
AUROC: 0.50146 [0.4742843, 0.52864086] | R²: 2.47e-08 [0.0, 0.00110175] | 0 | beta = log(or)/sd_pgs |
| PPM019979 | PGS004078 (megaprs.CV.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.67623 [2.34580171, 3.0531938] β: 0.98441 [0.85262722, 1.11618819] |
AUROC: 0.75808 [0.72109039, 0.79506729] | R²: 0.12382 [0.0893776, 0.1626812] | 0 | beta = log(or)/sd_pgs |
| PPM019978 | PGS004078 (megaprs.CV.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.39887 [1.26758241, 1.54375709] β: 0.33567 [0.23711147, 0.43421912] |
AUROC: 0.58756 [0.55830682, 0.61680998] | R²: 0.01282 [0.00631335, 0.02187257] | 0 | beta = log(or)/sd_pgs |
| PPM019985 | PGS004093 (prscs.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.96153 [1.81511617, 2.11974641] β: 0.67372 [0.59614947, 0.75129646] |
AUROC: 0.69109 [0.66721361, 0.71496653] | R²: 0.06749 [0.05179939, 0.08606836] | 0 | beta = log(or)/sd_pgs |
| PPM019986 | PGS004093 (prscs.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.44508 [2.37411415, 2.51816059] β: 0.89408 [0.86462438, 0.92352871] |
AUROC: 0.74221 [0.7347773, 0.74964128] | R²: 0.09841 [0.09204504, 0.10511922] | 0 | beta = log(or)/sd_pgs |
| PPM019987 | PGS004093 (prscs.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.0158 [0.92505185, 1.11545962] β: 0.01568 [-0.0779055, 0.10926654] |
AUROC: 0.49721 [0.47051134, 0.52391261] | R²: 3e-05 [0.0, 0.00165456] | 0 | beta = log(or)/sd_pgs |
| PPM019988 | PGS004093 (prscs.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.42395 [1.29147627, 1.57000849] β: 0.35343 [0.25578596, 0.45108103] |
AUROC: 0.58948 [0.55985079, 0.61910169] | R²: 0.01448 [0.00713355, 0.02556907] | 0 | beta = log(or)/sd_pgs |
| PPM019989 | PGS004093 (prscs.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.39116 [2.11480155, 2.70363906] β: 0.87178 [0.74896098, 0.99459867] |
AUROC: 0.74365 [0.70655591, 0.78075248] | R²: 0.11538 [0.08154941, 0.15461483] | 0 | beta = log(or)/sd_pgs |
| PPM019980 | PGS004102 (prscs.CV.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.98839 [1.83886186, 2.15008348] β: 0.68733 [0.60914683, 0.76550667] |
AUROC: 0.69368 [0.66982956, 0.71752171] | R²: 0.06902 [0.05359352, 0.08756059] | 0 | beta = log(or)/sd_pgs |
| PPM019981 | PGS004102 (prscs.CV.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.45742 [2.38456802, 2.53249357] β: 0.89911 [0.86901799, 0.92920442] |
AUROC: 0.74072 [0.73326604, 0.7481693] | R²: 0.09498 [0.08910449, 0.1012516] | 0 | beta = log(or)/sd_pgs |
| PPM019982 | PGS004102 (prscs.CV.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 0.99231 [0.90364856, 1.08967257] β: -0.00772 [-0.1013148, 0.08587725] |
AUROC: 0.50262 [0.47587981, 0.52935952] | R²: 8.22e-06 [0.0, 0.00119328] | 0 | beta = log(or)/sd_pgs |
| PPM019983 | PGS004102 (prscs.CV.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.42533 [1.29225034, 1.57211911] β: 0.3544 [0.25638515, 0.45242446] |
AUROC: 0.59074 [0.56115377, 0.62033237] | R²: 0.01445 [0.00709941, 0.02487634] | 0 | beta = log(or)/sd_pgs |
| PPM019984 | PGS004102 (prscs.CV.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.43145 [2.14880751, 2.75126545] β: 0.88849 [0.76491304, 1.01206097] |
AUROC: 0.74705 [0.70995893, 0.78413594] | R²: 0.1179 [0.08420483, 0.15729309] | 0 | beta = log(or)/sd_pgs |
| PPM019940 | PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.50723 [1.38329925, 1.64225382] β: 0.41027 [0.32447141, 0.49606958] |
AUROC: 0.61038 [0.58493393, 0.63583432] | R²: 0.01989 [0.01172729, 0.03067629] | 0 | beta = log(or)/sd_pgs |
| PPM019941 | PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.76472 [1.7129685, 1.81804229] β: 0.56799 [0.53822783, 0.59776026] |
AUROC: 0.65681 [0.64857862, 0.665043] | R²: 0.03778 [0.03378648, 0.04199483] | 0 | beta = log(or)/sd_pgs |
| PPM019942 | PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.06976 [0.97430512, 1.17457159] β: 0.06744 [-0.0260308, 0.16090348] |
AUROC: 0.51565 [0.4870758, 0.54421766] | R²: 0.00063 [0.0, 0.00417152] | 0 | beta = log(or)/sd_pgs |
| PPM019943 | PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.21972 [1.10575245, 1.34542335] β: 0.19862 [0.10052606, 0.29670872] |
AUROC: 0.55539 [0.52652748, 0.58425862] | R²: 0.00453 [0.00106382, 0.01025734] | 0 | beta = log(or)/sd_pgs |
| PPM019944 | PGS004117 (pt_clump.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.8907 [1.65320815, 2.16231652] β: 0.63695 [0.50271774, 0.77118011] |
AUROC: 0.67867 [0.64177739, 0.71555632] | R²: 0.04884 [0.02894078, 0.07332714] | 0 | beta = log(or)/sd_pgs |
| PPM019945 | PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.53997 [1.41224358, 1.67924688] β: 0.43176 [0.34517963, 0.5183454] |
AUROC: 0.61637 [0.59140768, 0.64133337] | R²: 0.02164 [0.01297279, 0.03167858] | 0 | beta = log(or)/sd_pgs |
| PPM019946 | PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.83108 [1.77691147, 1.88689599] β: 0.6049 [0.57487673, 0.63493314] |
AUROC: 0.66566 [0.65750331, 0.67382366] | R²: 0.04216 [0.03803437, 0.04646488] | 0 | beta = log(or)/sd_pgs |
| PPM019947 | PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.10378 [1.00525324, 1.21196356] β: 0.09874 [0.00523949, 0.19224182] |
AUROC: 0.52426 [0.49592976, 0.5525963] | R²: 0.00135 [0.0, 0.00571968] | 0 | beta = log(or)/sd_pgs |
| PPM019948 | PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.23285 [1.11742884, 1.36018681] β: 0.20933 [0.11103037, 0.30762205] |
AUROC: 0.5572 [0.52793354, 0.58646596] | R²: 0.00501 [0.00118351, 0.01159794] | 0 | beta = log(or)/sd_pgs |
| PPM019949 | PGS004132 (pt_clump_nested.CV.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.87052 [1.63223449, 2.14359629] β: 0.62622 [0.48994993, 0.76248493] |
AUROC: 0.67437 [0.63811128, 0.71062785] | R²: 0.04581 [0.02667374, 0.06787352] | 0 | beta = log(or)/sd_pgs |
| PPM019956 | PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.08691 [2.02370949, 2.15207932] β: 0.73568 [0.70493221, 0.7664345] |
AUROC: 0.69901 [0.69126203, 0.70676702] | R²: 0.05973 [0.05525799, 0.06439209] | 0 | beta = log(or)/sd_pgs |
| PPM019957 | PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 0.97765 [0.89040095, 1.07344813] β: -0.0226 [-0.1160834, 0.07087602] |
AUROC: 0.50592 [0.47842074, 0.53342715] | R²: 7e-05 [0.0, 0.00178835] | 0 | beta = log(or)/sd_pgs |
| PPM019958 | PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.32037 [1.19592399, 1.45777215] β: 0.27791 [0.1789191, 0.37690935] |
AUROC: 0.5779 [0.54954499, 0.60625601] | R²: 0.0087 [0.00397942, 0.01569235] | 0 | beta = log(or)/sd_pgs |
| PPM019959 | PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.73561 [1.51150462, 1.99293821] β: 0.55136 [0.41310559, 0.68961004] |
AUROC: 0.6586 [0.61898315, 0.69821584] | R²: 0.03445 [0.01835972, 0.05461851] | 0 | beta = log(or)/sd_pgs |
| PPM019955 | PGS004147 (sbayesr.auto.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.62883 [1.4923288, 1.77782255] β: 0.48786 [0.40033785, 0.57538933] |
AUROC: 0.63151 [0.60628925, 0.65673082] | R²: 0.02701 [0.01801814, 0.03863217] | 0 | beta = log(or)/sd_pgs |
| PPM019960 | PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PSS011224| European Ancestry| 199,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.35332 [2.16304039, 2.56032867] β: 0.85583 [0.77151482, 0.94013564] |
AUROC: 0.71754 [0.69281899, 0.74226865] | R²: 0.09161 [0.07185892, 0.11449842] | 0 | beta = log(or)/sd_pgs |
| PPM019961 | PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PSS011235| European Ancestry| 322,349 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.27887 [2.20957694, 2.35033807] β: 0.82368 [0.79280107, 0.85455918] |
AUROC: 0.71873 [0.71109285, 0.72636337] | R²: 0.07462 [0.06945443, 0.08005629] | 0 | beta = log(or)/sd_pgs |
| PPM019962 | PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PSS011248| South Asian Ancestry| 44,057 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.0051 [0.915294, 1.10371927] β: 0.00509 [-0.08851, 0.09868564] |
AUROC: 0.50466 [0.47785708, 0.53145331] | R²: 3.57e-06 [0.0, 0.00127941] | 0 | beta = log(or)/sd_pgs |
| PPM019963 | PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PSS011264| European Ancestry| 66,865 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 1.43168 [1.29788795, 1.57925912] β: 0.35885 [0.26073829, 0.45695583] |
AUROC: 0.58479 [0.5557021, 0.61387243] | R²: 0.01478 [0.00756708, 0.02570015] | 0 | beta = log(or)/sd_pgs |
| PPM019964 | PGS004162 (UKBB_EnsPGS.GCST90013445.T1D) |
PSS011277| European Ancestry| 90,274 individuals |
PGP000517 | Monti R et al. Am J Hum Genet (2024) |
Reported Trait: T1D | OR: 2.88687 [2.52605474, 3.29923292] β: 1.06017 [0.92665869, 1.19368999] |
AUROC: 0.77124 [0.73430954, 0.80816383] | R²: 0.14125 [0.10181365, 0.18523438] | 0 | beta = log(or)/sd_pgs |
| PPM020104 | PGS004171 (t1d_1) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.7 | — | year of birth, sex | — |
| PPM020105 | PGS004172 (t1d_2) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.71 | — | year of birth, sex | — |
| PPM020106 | PGS004173 (t1d_3) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.71 | — | year of birth, sex | — |
| PPM020107 | PGS004174 (t1d_4) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.71 | — | year of birth, sex | — |
| PPM020108 | PGS004175 (t1d_5) |
PSS011296| European Ancestry| 45,334 individuals |
PGP000520 | Raben TG et al. Sci Rep (2023) |
Reported Trait: Type 1 diabetes | — | AUROC: 0.7 | — | year of birth, sex | — |
| PPM021179 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011637| European Ancestry| 412,090 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 2.37 [2.31, 2.44] | C-index: 0.77 [0.77, 0.78] | — | PCs 1-10 | — |
| PPM021173 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011643| European Ancestry| 447,332 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 2.11 [1.98, 2.24] | — | — | PCs 1-10 | — |
| PPM021174 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011642| European Ancestry| 32,779 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 1.41 [1.17, 1.69] | C-index: 0.69 [0.64, 0.74] | — | PCs 1-10 | — |
| PPM021175 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011641| European Ancestry| 69,715 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 1.43 [1.28, 1.59] | C-index: 0.64 [0.61, 0.67] | — | PCs 1-10 | — |
| PPM021176 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011640| European Ancestry| 29,427 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 2.09 [1.91, 2.29] | C-index: 0.75 [0.72, 0.78] | — | PCs 1-10 | — |
| PPM021177 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011638| European Ancestry| 44,187 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 1.05 [0.95, 1.15] | — | — | PCs 1-10 | — |
| PPM021178 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011639| European Ancestry| 7,018 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 1.56 [1.14, 2.12] | C-index: 0.73 [0.67, 0.78] | — | PCs 1-10 | — |
| PPM021180 | PGS004874 (INTERVENE_MegaPRS_T1D) |
PSS011636| European Ancestry| 199,868 individuals |
PGP000618 | Jermy B et al. Nat Commun (2024) |
Reported Trait: Incident T1D | HR: 1.64 [1.5, 1.79] | C-index: 0.68 [0.65, 0.7] | — | PCs 1-10 | — |
| PPM021718 | PGS004930 (celiac_disease_snpnet_combined) |
PSS011762| European Ancestry| 8,417 individuals |
PGP000665 | Moreno-Grau S et al. Human Genomics (2024) |
Reported Trait: Celiac disease | OR: 1.52 [1.35, 1.71] | AUROC: 0.67 | — | — | — |
| PPM023441 | PGS005398 (T1D_PRS_combined) |
PSS012186| European Ancestry| 2,771 individuals |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Reported Trait: Type 1 diabetes diagnosis | OR: 1.586 [1.42, 1.771] | AUROC: 0.629 [0.6, 0.658] | — | — | — |
| PPM023442 | PGS005399 (T1D_PRS_male) |
PSS012188| European Ancestry| 1,435 individuals |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Reported Trait: Type 1 diabetes diagnosis | OR: 1.896 [1.627, 2.21] | AUROC: 0.668 [0.629, 0.707] | delta AUC (sex‑specific-all‑samples): 0.0444 [0.0341, 0.0546] | — | DeLong's test (2‑correlated ROC curves): Z = -8.4547, p < 2.2 × 10⁻¹⁶ ; Bootstrap test (2,000 stratified replicates): D = -8.3838, p < 2.2 × 10⁻¹⁶ |
| PPM023443 | PGS005400 (T1D_PRS_female) |
PSS012187| European Ancestry| 1,336 individuals |
PGP000781 | Qu HQ et al. Diabetes Res Clin Pract (2026) |
Reported Trait: Type 1 diabetes diagnosis | OR: 2.316 [1.962, 2.732] | AUROC: 0.719 [0.682, 0.756] | delta AUC (sex‑specific-all‑samples): 0.084 [0.0646, 0.1035] | — | DeLong's test (2‑correlated ROC curves): Z = -8.4667, p < 2.2 × 10⁻¹⁶; Bootstrap test (2,000 stratified replicates): D = -8.3857, p < 2.2 × 10⁻¹⁶ |
| PPM030675 | PGS012555 (TA-PS) |
PSS012239| African Ancestry| 1,687 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.729 [0.699, 0.759] | — | — | sensitivity (%, cutoff of 10) = 0.310, specificity (%, cutoff of 10) = 0.941, F1 score = 0.409 |
| PPM030676 | PGS012555 (TA-PS) |
PSS012240| European Ancestry| 2,828 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.777 [0.754, 0.8] | — | — | sensitivity (%, cutoff of 10) = 0.409, specificity (%, cutoff of 10) = 0.900, F1 score = 0.428 |
| PPM030677 | PGS012555 (TA-PS) |
PSS012242| South Asian Ancestry| 315 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.736 [0.644, 0.829] | — | — | sensitivity (%, cutoff of 10) = 0.333, specificity (%, cutoff of 10) = 0.883, F1 score = 0.270 |
| PPM030678 | PGS012555 (TA-PS) |
PSS012241| Additional Diverse Ancestries| 1,285 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.72 [0.678, 0.762] | — | — | sensitivity (%, cutoff of 10) = 0.366, specificity (%, cutoff of 10) = 0.913, F1 score = 0.399 |
| PPM030679 | PGS012555 (TA-PS) |
PSS012243| East Asian Ancestry| 596 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.81 [0.775, 0.844] | — | — | sensitivity (%, cutoff of 10) = 0.527, specificity (%, cutoff of 10) = 0.897, F1 score = 0.646 |
| PPM030681 | PGS012555 (TA-PS) |
PSS012237| Hispanic or Latin American Ancestry| 18,753 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.688 [0.654, 0.688] | — | — | sensitivity (%, cutoff of 10) = 0.329, specificity (%, cutoff of 10) = 0.903, F1 score = 0.069 |
| PPM030682 | PGS012555 (TA-PS) |
PSS012235| African Ancestry| 14,974 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.652 [0.61, 0.652] | — | — | sensitivity (%, cutoff of 10) = 0.335, specificity (%, cutoff of 10) = 0.903, F1 score = 0.080 |
| PPM030683 | PGS012555 (TA-PS) |
PSS012238| Multi-ancestry (including European)| 86,010 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.752 [0.735, 0.769] | — | — | sensitivity (%, cutoff of 10) = 0.460, specificity (%, cutoff of 10) = 0.904, F1 score = 0.096 |
| PPM030684 | PGS012555 (TA-PS) |
PSS012244| European Ancestry| 406,390 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.857 [0.842, 0.873] | — | — | sensitivity (%, cutoff of 10) = 0.669, specificity (%, cutoff of 10) = 0.900, F1 score = 0.024 |
| PPM030680 | PGS012555 (TA-PS) |
PSS012236| European Ancestry| 52,283 individuals |
PGP000798 | Jumentier B et al. Diabetologia (2026) |
Reported Trait: type 1 diabetes | — | AUROC: 0.821 [0.8, 0.821] | — | — | sensitivity (%, cutoff of 10) = 0.597, specificity (%, cutoff of 10) = 0.905, F1 score = 0.116 |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS009164 | — | — | 1,354 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS008659 | — | — | 5,445 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS003667 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS003668 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS003669 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS003670 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS008169 | — | — | 5,228 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS008718 | — | — | 2,442 individuals | — | European | Italy (South Europe) | UKB | — |
| PSS012104 | — | — | 73,872 individuals | — | European | — | MVP | — |
| PSS012104 | — | — | 25,274 individuals | — | African unspecified | — | MVP | — |
| PSS012104 | — | — | 9,537 individuals | — | Hispanic or Latin American | — | MVP | — |
| PSS012104 | — | — | 911 individuals | — | Asian unspecified | — | MVP | — |
| PSS008213 | — | — | 5,277 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS011224 | — | — | [
|
— | European | — | EB | — |
| PSS009893 | — | — | 366 individuals | — | African American or Afro-Caribbean | — | SEARCH | — |
| PSS009894 | — | — | 412 individuals | — | Hispanic or Latin American | — | SEARCH | — |
| PSS009895 | — | — | 1,168 individuals | — | European | — | SEARCH | — |
| PSS009896 | — | — | 99 individuals | — | Not reported | — | SEARCH | — |
| PSS011235 | T1D, ICD10: E10, ICD9: 250[0|1]1 (exclude E11) | — | [
|
— | European | — | FinnGen | — |
| PSS000026 | Cases were defined on the presence or absence of severe insulin deficiency (requiring insulin treatment at 3 years after diagnosis). We cate- gorized people as severely insulin defi- cient if they received continuous insulin treatment at ,3 years from the time of diagnosis and had a low measured C-peptide level (nonfasting measured ,0.6 nmol/L or equivalent fasting blood glucose level or posthome meal urine C-peptide–to–creatinine ratio) | — | [ ,
46.3 % Male samples |
— | European | — | P2ID | A cross-sectional cohort of people in whom diabetes was diagnosed between the ages of 20 and 40 years (n = 223), who had had diabetes for .3 years, and who had self-reported as white European from Devon and Cornwall in South West England. Known monogenic diabetes and secondary diabetes pa- tients were excluded. |
| PSS000027 | Type 1 diabetes status was assigned according to clinician diagnosis. | — | [ ,
33.78 % Male samples |
— | African American or Afro-Caribbean | — | UFDI | Total sample number contains the number of controls, cases, and includes the number of first/second-degree relatives and samples identified as "at risk" (autoantibody positive) used in other analyses. |
| PSS000028 | Type 1 diabetes status was assigned according to clinician diagnosis. | — | [ ,
44.84 % Male samples |
— | Hispanic or Latin American | Samples labeled Caucasian (Hispanic ethnicity) in the original publication. | UFDI | Total sample number contains the number of controls, cases, and includes the number of first/second-degree relatives and samples identified as "at risk" (autoantibody positive) used in other analyses. |
| PSS000029 | Type 1 diabetes status was assigned according to clinician diagnosis. | — | [ ,
47.34 % Male samples |
— | European | Samples labeled Caucasian (non-Hispanic) in the original publication. | UFDI | Total sample number contains the number of controls, cases, and includes the number of first/second-degree relatives and samples identified as "at risk" (autoantibody positive) used in other analyses. |
| PSS011643 | — | — | [
|
— | European | — | UKB | — |
| PSS011248 | — | — | [
|
— | South Asian | — | G&H | — |
| PSS000030 | — | — | [
|
— | African unspecified | — | 7 cohorts
|
— |
| PSS000031 | Cases are diagnosed with type 1 diabetes. | — | [
|
— | African unspecified | — | UOF | — |
| PSS000032 | Type 1 Diabetes Case Definition = Clinical diagnosis of diabetes at less than or equal to 20 years of age; On insulin within 1 year from the time of diagnosis; Still on insulin at the time of recruit- ment; Not using oral antihyperglycemic agents; Did not ever self-report as having type 2 diabetes (T2D) | — | [
|
— | European | — | UKB | — |
| PSS007737 | — | — | 2,200 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS011264 | — | — | [
|
— | European | — | HUNT | — |
| PSS009287 | — | — | 18,975 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS011277 | — | — | [
|
— | European | — | UKB | — |
| PSS008270 | — | — | 908 individuals | — | South Asian | India (South Asia) | UKB | — |
| PSS012186 | Type 1 diabetes, diagnosed by physician; cases confirmed through clinical criteria at CHOP. ICD-10 code E10 used where available. | — | [ ,
51.7 % Male samples |
— | European | — | CHOP | Independent validation cohort recruited through the Children's Hospital of Philadelphia (CHOP). No overlap with discovery GWAS samples. |
| PSS012187 | Type 1 diabetes, diagnosed by physician; cases confirmed through clinical criteria at CHOP. ICD-10 code E10 used where available. | — | [ ,
0.0 % Male samples |
— | European | — | CHOP | Independent validation cohort recruited through the Children's Hospital of Philadelphia (CHOP). No overlap with discovery GWAS samples. |
| PSS011295 | — | — | 1,798 individuals | — | Not reported | — | NR | StartRight |
| PSS007778 | — | — | 2,091 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS011296 | 22,667 sibling pairs | — | 45,334 individuals | — | European | — | UKB | — |
| PSS012235 | — | — | [
|
— | African American or Afro-Caribbean | — | AllofUs | — |
| PSS012236 | — | — | [
|
— | European | — | AllofUs | — |
| PSS012237 | — | — | [
|
— | Hispanic or Latin American | — | AllofUs | — |
| PSS012238 | — | — | [
|
— | African American or Afro-Caribbean | — | AllofUs | — |
| PSS009331 | — | — | 16,106 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS012238 | — | — | [
|
— | Hispanic or Latin American | — | AllofUs | — |
| PSS012239 | — | — | [
|
— | African American or Afro-Caribbean | — | CHOP | — |
| PSS012240 | — | — | [
|
— | European | — | CHOP | — |
| PSS012241 | — | — | [
|
— | Other admixed ancestry | — | CHOP | — |
| PSS012242 | — | — | [
|
— | South Asian | — | CHOP | — |
| PSS012243 | — | — | [
|
— | East Asian | — | GRACE | — |
| PSS012238 | — | — | [
|
— | European | — | AllofUs | — |
| PSS012244 | — | — | [
|
— | European | — | UKB | — |
| PSS008840 | — | — | 3,490 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS000059 | — | — | [
|
— | European (Finnish) |
— | FINRISK, Health2000 | — |
| PSS000060 | — | — | [
|
— | European (British) |
— | NR | Immunochip |
| PSS011762 | — | — | 8,417 individuals | — | European | — | BBofA | — |
| PSS000061 | — | — | [
|
— | European (Italian) |
— | NR | — |
| PSS000062 | — | — | [
|
— | European (Dutch) |
— | NR | — |
| PSS000063 | — | — | [
|
— | European (British) |
— | NR | — |
| PSS007834 | — | — | 400 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
| PSS000064 | — | — | [
|
— | European | — | NIDDK | — |
| PSS000065 | The HLA-DQ2.5-positive subset of NIDDK-CIDR | — | [
|
— | European | — | NIDDK | HLA alleles were imputed using SNP2HLA |
| PSS012260 | — | — | 158 individuals | — | European | — | FDS | — |
| PSS009390 | — | — | 7,142 individuals | — | European | UK (+ Ireland) | UKB | — |
| PSS008882 | — | — | 3,455 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS008391 | — | — | 1,107 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS004423 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004424 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS000083 | Cases were clinically diagnosed with T1D before 17 years of age and treated with insulin from diagnosis. Patients with known MODY or NDM were excluded. | — | [
|
— | European | — | WTCCC | Cases with Type 1 Diabetes |
| PSS000083 | MODY patients with a confirmed monogenic etiology on genetic testing (415 patients with HNF1A MODY, 346 with GCK MODY, 42 with HNF4A MODY, and 2 with HNF1B MODY). The median age of diagnosis was 20 years (interquartile range 15, 30), and 532 patients were female. | — | [ ,
33.91 % Male samples |
— | European | — | NR | Maturity-onset diabetes of young (MODY) cases ascertained from the Genetic Βeta Cell Research Bank, Exeter, U.K. |
| PSS004425 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004426 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS011531 | Cases were individuals with T1D | — | [ ,
53.51 % Male samples |
— | European | — | NR | — |
| PSS011532 | Cases were individuals with T1D | — | [ ,
53.79 % Male samples |
— | European | — | NR | — |
| PSS008938 | — | — | 526 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
| PSS004457 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004458 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004459 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004460 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS008433 | — | — | 998 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS001084 | Moderate Age-Related Diabetes (MARD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001085 | Moderate Obesity-related Diabetes (MOD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001086 | Severe Autoimmune Diabetes (SAID) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS001087 | Severe Insulin-Deficient Diabetes (SIDD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS007956 | — | — | 1,729 individuals | — | East Asian | China (East Asia) | UKB | — |
| PSS008492 | — | — | 208 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
| PSS000368 | TEDDY children were followed prospectively from 3–4 months of age, with visits every 3 months until 4 years of age. Each evaluation tested the three islet antibodies (GADA, IA2A and IAA), changes in family history, as well as other measurements specified by the TEDDY protocol. After 4 years of age, children with any islet autoantibodies remained on quarterly visits, while antibody-negative children were evaluated every 6 months. Children were followed prospectively until 15 years of age or until T1D onset, as defined using the American Diabetes Association’s criteria for diagnosis (doi: 10.1196/annals.1447.062) | Median = 9.3 years Range = [0.0833, 14.0] years |
[ ,
50.86 % Male samples |
Range = [3.0, 4.0] years | NR | — | TEDDY | From 2004–2010, 424,788 newborns were screened at six US and European centers for high-risk HLA genotypes. TEDDY then enrolled 8,676 eligible infants with the intent to follow them until 15 years of age. The three major eligible HLA DR–DQ haplotypes are DR3–DQA1*0501–DQB1*0201, DR4–DQA1*0301–DQB1*0302 and DR8–DQA1*0401–DQB1*0402. |
| PSS011636 | — | — | [
|
— | European | — | EB | — |
| PSS011637 | — | — | [
|
— | European | — | FinnGen | — |
| PSS011638 | — | — | [
|
— | European | — | G&H | — |
| PSS011639 | — | — | [
|
— | European | — | GS:SFHS | — |
| PSS011640 | — | — | [
|
— | European | — | GEL | — |
| PSS011641 | — | — | [
|
— | European | — | HUNT | — |
| PSS011642 | — | — | [
|
— | European | — | MGBB | — |
| PSS004570 | — | — | [
|
— | African unspecified | — | UKB | — |
| PSS004571 | — | — | [
|
— | East Asian | — | UKB | — |
| PSS004572 | — | — | [
|
— | European | non-white British ancestry | UKB | — |
| PSS004573 | — | — | [
|
— | South Asian | — | UKB | — |
| PSS004574 | — | — | [
|
— | European | white British ancestry | UKB | Testing cohort (heldout set) |
| PSS009061 | — | — | 3,954 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS010998 | — | — | [
|
— | European | — | MGI | — |
| PSS011000 | — | — | [
|
— | European | — | UKB | — |
| PSS011001 | — | — | [
|
— | European | — | UKB | — |
| PSS010999 | — | — | [
|
— | European | — | UKB | — |
| PSS012188 | Type 1 diabetes, diagnosed by physician; cases confirmed through clinical criteria at CHOP. ICD-10 code E10 used where available. | — | [ ,
100.0 % Male samples |
— | European | — | CHOP | Independent validation cohort recruited through the Children's Hospital of Philadelphia (CHOP). No overlap with discovery GWAS samples. |
| PSS011009 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 16,663 individuals, 48.0 % Male samples |
Mean = 51.9 years Sd = 14.8 years |
European | Self-identified race = White | BioMe | — |
| PSS011009 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 11,443 individuals, 39.0 % Male samples |
Mean = 48.4 years Sd = 14.1 years |
African American or Afro-Caribbean | Self-identified race = Black | BioMe | — |
| PSS011009 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 19,524 individuals, 37.0 % Male samples |
Mean = 50.3 years Sd = 15.3 years |
Hispanic or Latin American | Self-identified race = Hispanic | BioMe | — |
| PSS011009 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 10,013 individuals, 46.0 % Male samples |
Mean = 55.9 years Sd = 13.9 years |
East Asian, South East Asian, Native American, South Asian, Other | Self-identified race = Other | BioMe | — |
| PSS011010 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 11,443 individuals, 39.0 % Male samples |
Mean = 48.4 years Sd = 14.1 years |
African American or Afro-Caribbean | Self-identified race = Black | BioMe | — |
| PSS011010 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 19,524 individuals, 37.0 % Male samples |
Mean = 50.3 years Sd = 15.3 years |
Hispanic or Latin American | Self-identified race = Hispanic | BioMe | — |
| PSS011010 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 10,013 individuals, 46.0 % Male samples |
Mean = 55.9 years Sd = 13.9 years |
East Asian, South East Asian, Native American, South Asian, Other | Self-identified race = Other | BioMe | — |
| PSS011011 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 16,663 individuals, 48.0 % Male samples |
Mean = 51.9 years Sd = 14.8 years |
European | Self-identified race = White | BioMe | — |
| PSS011012 | — | — | 34,939 individuals, 47.0 % Male samples |
Mean = 59.1 years Sd = 16.9 years |
European | Self-identified race = white | MGBB | — |
| PSS011012 | — | — | 2,101 individuals, 37.0 % Male samples |
Mean = 52.1 years Sd = 16.3 years |
African American or Afro-Caribbean (Black) |
— | MGBB | — |
| PSS011012 | — | — | 1,269 individuals, 34.0 % Male samples |
Mean = 46.4 years Sd = 16.1 years |
Hispanic or Latin American (Hispanic) |
— | MGBB | — |
| PSS011012 | — | — | 1,511 individuals, 36.0 % Male samples |
Mean = 46.9 years Sd = 16.3 years |
Native American, Asian unspecified, Oceanian, Other | — | MGBB | — |
| PSS011013 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 2,101 individuals, 37.0 % Male samples |
Mean = 52.1 years Sd = 16.3 years |
African American or Afro-Caribbean | Self-identified race = Black | MGBB | — |
| PSS011013 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 1,269 individuals, 34.0 % Male samples |
Mean = 46.4 years Sd = 16.1 years |
Hispanic or Latin American | Self-identified race = Hispanic | MGBB | — |
| PSS011013 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 1,511 individuals, 36.0 % Male samples |
Mean = 46.9 years Sd = 16.3 years |
Native American, Asian unspecified, Oceanian, Other | Self-identified race = Other | MGBB | — |
| PSS001088 | Severe Insulin-Resistant Diabetes (SIRD) vs. controls | — | [
|
— | European | Swedish | ANDIS | — |
| PSS011014 | At each site, a trained medical reviewer performed manual record review for all individuals identified as having type 1 diabetes by the eMERGE algorithm. To confirm a diagnosis of type 1 diabetes, participants had to meet all of the following criteria, modified from (13): Diagnosis confirmed by an endocrinologist or primary care physician Current use of basal-bolus insulin or pump No secondary cause of diabetes listed in the medical record: gestational diabetes, checkpoint inhibitor use, glucocorticoid-induced diabetes, cystic fibrosis diagnosis, hemochromatosis, pancreatogenic diabetes, posttransplantation diabetes, maturity-onset diabetes of the young, or diagnosis of type 1.5 diabetes | — | 34,939 individuals, 47.0 % Male samples |
Mean = 59.1 years Sd = 16.9 years |
European | Self-identified race = White | MGBB | — |
| PSS000381 | Diagnosis of coeliac disease was made by endoscopy for patients referred to a tertiary paediatric clinic in Alberta, Canada, for consideration of coeliac disease diagnosis | — | [ ,
57.0 % Male samples |
Mean = 7.5 years Sd = 3.8 years |
NR | — | STOLLERY_CC | — |
| PSS000381 | Diagnosis of coeliac disease was made by a modification of European serological diagnostic guidelines for patients referred to a tertiary paediatric clinic in Alberta, Canada, for consideration of coeliac disease diagnosis | — | [ ,
63.0 % Male samples |
Mean = 8.6 years Sd = 3.9 years |
NR | — | STOLLERY_CC | — |
| PSS000381 | Control subjects (n = 40) were paediatric general gastroenterology patients whom were negative for coeliac disease by both intestinal biopsy and negative tissue transglutaminase serology. | — | [ ,
48.0 % Male samples |
Mean = 4.9 years Sd = 4.0 years |
NR | — | STOLLERY_CC | — |
| PSS000382 | Coeliac disease cases were identified using either hospital admission code and/or self‐reported coeliac disease. | — | [
|
— | European | — | UKB | — |
| PSS009105 | — | — | 3,509 individuals | — | European | Poland (NE Europe) | UKB | — |
| PSS001092 | All individuals had cystic fibrosis with either 2 severe CFTR mutations and/or clinically diagnosed exocrine pancreatic insufficiency. Cases are individuals with cystic fibrosis related diabetes (CFRD).Phenotypes were obtained from extracted medical charts and CF Foundation Patient Registry through 2011. CFRD was defined by clinician diagnosis of diabetes plus insulin treatment for at least 1 year. The onset of CFRD was defined as the date at which insulin was started, if it was subsequently continued for at least 1 year. In approximately 50% of the participants, independent laboratory data (such as oral glucose tolerance test or hemoglobin A1c) were able to independently confirm the diagnosis of CFRD. Diabetes data were censored at the last clinic visit or date of solid organ transplant. | — | [ ,
47.04 % Male samples |
Mean = 20.0 years | Not reported | — | CGS, CWRU, FrGMC, JHU, UNC | — |
| PSS008615 | — | — | 6,300 individuals | — | European | Italy (South Europe) | UKB | — |