Trait: hypertensive heart disease

Trait Information
Identifier MONDO_0001302
Description Abnormal enlargement of the heart resulting from long-standing hypertension. [NCIT: C4907]
Trait category
Other trait
Synonym hypertensive heart disease

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019138
(TPMI_401.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 73,378
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019138/ScoringFiles/PGS019138.txt.gz
PGS019139
(TPMI_401.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 939,834
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019139/ScoringFiles/PGS019139.txt.gz
PGS019140
(TPMI_401.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 116,032
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019140/ScoringFiles/PGS019140.txt.gz
PGS019141
(TPMI_401.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 983,785
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019141/ScoringFiles/PGS019141.txt.gz
PGS019142
(TPMI_401.2_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 1,071,467
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019142/ScoringFiles/PGS019142.txt.gz
PGS019143
(TPMI_401.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart and or renal disease hypertensive heart disease 1,018,628
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019143/ScoringFiles/PGS019143.txt.gz
PGS019149
(TPMI_401.21_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 69,926
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019149/ScoringFiles/PGS019149.txt.gz
PGS019150
(TPMI_401.21_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 939,832
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019150/ScoringFiles/PGS019150.txt.gz
PGS019151
(TPMI_401.21_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 86,725
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019151/ScoringFiles/PGS019151.txt.gz
PGS019152
(TPMI_401.21_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 983,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019152/ScoringFiles/PGS019152.txt.gz
PGS019153
(TPMI_401.21_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 1,071,463
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019153/ScoringFiles/PGS019153.txt.gz
PGS019154
(TPMI_401.21_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hypertensive heart disease hypertensive heart disease 1,001,869
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019154/ScoringFiles/PGS019154.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037320 PGS019138
(TPMI_401.2_Lassosum2)
 PSS013041|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.63849 R²: 0.05806 sex, age, array, PCs 1-10 —
PPM037321 PGS019139
(TPMI_401.2_LDpred2)
 PSS013040|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.64308 R²: 0.06165 sex, age, array, PCs 1-10 —
PPM037322 PGS019140
(TPMI_401.2_MegaPRS)
 PSS013042|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.63399 R²: 0.05569 sex, age, array, PCs 1-10 —
PPM037323 PGS019141
(TPMI_401.2_PRS-CS)
 PSS013043|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.63921 R²: 0.05839 sex, age, array, PCs 1-10 —
PPM037324 PGS019142
(TPMI_401.2_PRSmix+)
 PSS013044|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.66636 R²: 0.08306 sex, age, array, PCs 1-10 —
PPM037325 PGS019143
(TPMI_401.2_SBayesR)
 PSS013045|
East Asian Ancestry|
15,062 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart and or renal disease — AUROC: 0.63493 R²: 0.05432 sex, age, array, PCs 1-10 —
PPM037331 PGS019149
(TPMI_401.21_Lassosum2)
 PSS013035|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.6402 R²: 0.05744 sex, age, array, PCs 1-10 —
PPM037332 PGS019150
(TPMI_401.21_LDpred2)
 PSS013034|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.64356 R²: 0.06085 sex, age, array, PCs 1-10 —
PPM037333 PGS019151
(TPMI_401.21_MegaPRS)
 PSS013036|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.63342 R²: 0.05337 sex, age, array, PCs 1-10 —
PPM037334 PGS019152
(TPMI_401.21_PRS-CS)
 PSS013037|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.6376 R²: 0.056 sex, age, array, PCs 1-10 —
PPM037335 PGS019153
(TPMI_401.21_PRSmix+)
 PSS013038|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.66644 R²: 0.08093 sex, age, array, PCs 1-10 —
PPM037336 PGS019154
(TPMI_401.21_SBayesR)
 PSS013039|
East Asian Ancestry|
14,851 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hypertensive heart disease — AUROC: 0.63323 R²: 0.0517 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013034 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013035 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013036 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013037 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013038 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013039 402,I11 —
[
  • 2,122 cases
  • , 12,729 controls
]
,
42.22 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013040 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013041 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013042 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013043 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013044 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013045 402, 403, 404,I11, I12, I13 —
[
  • 2,333 cases
  • , 12,729 controls
]
,
42.49 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —