Trait: palindromic rheumatism

Trait Information
Identifier MONDO_0001332
Description A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results in no joint damage or symptoms. [DOID: 1166]
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019687
(TPMI_716.8_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Palindromic rheumatism palindromic rheumatism 40
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019687/ScoringFiles/PGS019687.txt.gz
PGS019688
(TPMI_716.8_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Palindromic rheumatism palindromic rheumatism 939,830
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019688/ScoringFiles/PGS019688.txt.gz
PGS019689
(TPMI_716.8_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Palindromic rheumatism palindromic rheumatism 402,924
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019689/ScoringFiles/PGS019689.txt.gz
PGS019690
(TPMI_716.8_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Palindromic rheumatism palindromic rheumatism 983,781
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019690/ScoringFiles/PGS019690.txt.gz
PGS019691
(TPMI_716.8_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Palindromic rheumatism palindromic rheumatism 1,000,628
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019691/ScoringFiles/PGS019691.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037869 PGS019687
(TPMI_716.8_Lassosum2)
 PSS013585|
East Asian Ancestry|
17,549 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Palindromic rheumatism — AUROC: 0.88197 R²: 0.06193 sex, age, array, PCs 1-10 —
PPM037870 PGS019688
(TPMI_716.8_LDpred2)
 PSS013584|
East Asian Ancestry|
17,549 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Palindromic rheumatism — AUROC: 0.88299 R²: 0.06265 sex, age, array, PCs 1-10 —
PPM037871 PGS019689
(TPMI_716.8_MegaPRS)
 PSS013586|
East Asian Ancestry|
17,549 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Palindromic rheumatism — AUROC: 0.87892 R²: 0.06075 sex, age, array, PCs 1-10 —
PPM037872 PGS019690
(TPMI_716.8_PRS-CS)
 PSS013587|
East Asian Ancestry|
17,549 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Palindromic rheumatism — AUROC: 0.88087 R²: 0.0618 sex, age, array, PCs 1-10 —
PPM037873 PGS019691
(TPMI_716.8_SBayesR)
 PSS013588|
East Asian Ancestry|
17,549 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Palindromic rheumatism — AUROC: 0.87922 R²: 0.06086 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013584 719.3,M12.3, M12.4 —
[
  • 161 cases
  • , 17,388 controls
]
,
47.31 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013585 719.3,M12.3, M12.4 —
[
  • 161 cases
  • , 17,388 controls
]
,
47.31 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013586 719.3,M12.3, M12.4 —
[
  • 161 cases
  • , 17,388 controls
]
,
47.31 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013587 719.3,M12.3, M12.4 —
[
  • 161 cases
  • , 17,388 controls
]
,
47.31 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013588 719.3,M12.3, M12.4 —
[
  • 161 cases
  • , 17,388 controls
]
,
47.31 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —