Trait: inflammatory spondylopathy

Trait Information
Identifier MONDO_0001434
Trait category
Other trait
Synonyms 2 synonyms
  • inflammatory spondylopathies in disease classified elsewhere
  • inflammatory spondylopathy in disease classified elsewhere

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019666
(TPMI_715_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 27
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019666/ScoringFiles/PGS019666.txt.gz
PGS019667
(TPMI_715_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 939,889
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019667/ScoringFiles/PGS019667.txt.gz
PGS019668
(TPMI_715_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 294,406
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019668/ScoringFiles/PGS019668.txt.gz
PGS019669
(TPMI_715_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 983,832
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019669/ScoringFiles/PGS019669.txt.gz
PGS019670
(TPMI_715_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Other inflammatory spondylopathies inflammatory spondylopathy 791,011
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019670/ScoringFiles/PGS019670.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037848 PGS019666
(TPMI_715_Lassosum2)
 PSS013575|
East Asian Ancestry|
18,447 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other inflammatory spondylopathies — AUROC: 0.77155 R²: 0.19045 sex, age, array, PCs 1-10 —
PPM037849 PGS019667
(TPMI_715_LDpred2)
 PSS013574|
East Asian Ancestry|
18,447 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other inflammatory spondylopathies — AUROC: 0.77135 R²: 0.19831 sex, age, array, PCs 1-10 —
PPM037850 PGS019668
(TPMI_715_MegaPRS)
 PSS013576|
East Asian Ancestry|
18,447 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other inflammatory spondylopathies — AUROC: 0.75763 R²: 0.10413 sex, age, array, PCs 1-10 —
PPM037851 PGS019669
(TPMI_715_PRS-CS)
 PSS013577|
East Asian Ancestry|
18,447 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other inflammatory spondylopathies — AUROC: 0.78205 R²: 0.21691 sex, age, array, PCs 1-10 —
PPM037852 PGS019670
(TPMI_715_SBayesR)
 PSS013578|
East Asian Ancestry|
18,447 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Other inflammatory spondylopathies — AUROC: 0.7758 R²: 0.16313 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013574 720,M08.1, M45, M46, M49 —
[
  • 419 cases
  • , 18,028 controls
]
,
47.42 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013575 720,M08.1, M45, M46, M49 —
[
  • 419 cases
  • , 18,028 controls
]
,
47.42 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013576 720,M08.1, M45, M46, M49 —
[
  • 419 cases
  • , 18,028 controls
]
,
47.42 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013577 720,M08.1, M45, M46, M49 —
[
  • 419 cases
  • , 18,028 controls
]
,
47.42 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013578 720,M08.1, M45, M46, M49 —
[
  • 419 cases
  • , 18,028 controls
]
,
47.42 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —