Trait: prolapse of female genital organ

Trait Information
Identifier MONDO_0001592
Trait category
Other disease
Mapped terms 7 mapped terms
  • DOID:1284
  • ICD10CM:N81
  • ICD9:618.8
  • ICD9:618.89
  • MEDGEN:510253
  • SCTID:73998008
  • UMLS:C0156349

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS001867
(portability-PLR_618)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Genital prolapse prolapse of female genital organ 9,708
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001867/ScoringFiles/PGS001867.txt.gz
PGS002078
(portability-ldpred2_618)
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Genital prolapse prolapse of female genital organ 774,553
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002078/ScoringFiles/PGS002078.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009825 PGS001867
(portability-PLR_618)
 PSS009342|
European Ancestry|
10,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0425 [0.0237, 0.0613] sex, age, birth date, deprivation index, 16 PCs —
PPM009826 PGS001867
(portability-PLR_618)
 PSS009116|
European Ancestry|
2,578 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0481 [0.0094, 0.0867] sex, age, birth date, deprivation index, 16 PCs —
PPM009828 PGS001867
(portability-PLR_618)
 PSS008444|
Greater Middle Eastern Ancestry|
483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): -0.0042 [-0.0952, 0.0869] sex, age, birth date, deprivation index, 16 PCs —
PPM009829 PGS001867
(portability-PLR_618)
 PSS008224|
South Asian Ancestry|
2,902 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0503 [0.0138, 0.0866] sex, age, birth date, deprivation index, 16 PCs —
PPM009830 PGS001867
(portability-PLR_618)
 PSS008005|
East Asian Ancestry|
1,207 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0167 [-0.0403, 0.0735] sex, age, birth date, deprivation index, 16 PCs —
PPM009831 PGS001867
(portability-PLR_618)
 PSS007789|
African Ancestry|
1,584 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0381 [-0.0115, 0.0875] sex, age, birth date, deprivation index, 16 PCs —
PPM009832 PGS001867
(portability-PLR_618)
 PSS008893|
African Ancestry|
2,113 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.037 [-0.0059, 0.0797] sex, age, birth date, deprivation index, 16 PCs —
PPM009827 PGS001867
(portability-PLR_618)
 PSS008670|
European Ancestry|
3,676 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0389 [0.0065, 0.0712] sex, age, birth date, deprivation index, 16 PCs —
PPM039129 PGS001867
(portability-PLR_618)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.01015 — — — —
PPM011485 PGS002078
(portability-ldpred2_618)
 PSS009342|
European Ancestry|
10,810 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0672 [0.0484, 0.086] sex, age, birth date, deprivation index, 16 PCs —
PPM011486 PGS002078
(portability-ldpred2_618)
 PSS009116|
European Ancestry|
2,578 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0581 [0.0193, 0.0966] sex, age, birth date, deprivation index, 16 PCs —
PPM011487 PGS002078
(portability-ldpred2_618)
 PSS008670|
European Ancestry|
3,676 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0568 [0.0244, 0.089] sex, age, birth date, deprivation index, 16 PCs —
PPM011488 PGS002078
(portability-ldpred2_618)
 PSS008444|
Greater Middle Eastern Ancestry|
483 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0251 [-0.0661, 0.1158] sex, age, birth date, deprivation index, 16 PCs —
PPM011489 PGS002078
(portability-ldpred2_618)
 PSS008224|
South Asian Ancestry|
2,902 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0422 [0.0057, 0.0786] sex, age, birth date, deprivation index, 16 PCs —
PPM011490 PGS002078
(portability-ldpred2_618)
 PSS008005|
East Asian Ancestry|
1,207 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0112 [-0.0457, 0.0681] sex, age, birth date, deprivation index, 16 PCs —
PPM011491 PGS002078
(portability-ldpred2_618)
 PSS007789|
African Ancestry|
1,584 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0278 [-0.0218, 0.0772] sex, age, birth date, deprivation index, 16 PCs —
PPM011492 PGS002078
(portability-ldpred2_618)
 PSS008893|
African Ancestry|
2,113 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Genital prolapse — — Partial Correlation (partial-r): 0.0403 [-0.0025, 0.083] sex, age, birth date, deprivation index, 16 PCs —
PPM038784 PGS002078
(portability-ldpred2_618)
 PSS013916|
European Ancestry|
425,240 individuals
 PGP000865 |
Bhatt IS et al. J Assoc Res Otolaryngol (2024)
|Ext.		 Reported Trait: Age-related hearing difficulty β: 0.01717 — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008005 — — 1,207 individuals — East Asian China (East Asia) UKB —
PSS008444 — — 483 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007789 — — 1,584 individuals — African American or Afro-Caribbean Carribean UKB —
PSS013916 — —
[
  • 111,243 cases
  • , 313,997 controls
]
,
46.21 % Male samples
 — European
(British, Irish)		 — UKB —
PSS008670 — — 3,676 individuals — European Italy (South Europe) UKB —
PSS009116 — — 2,578 individuals — European Poland (NE Europe) UKB —
PSS008893 — — 2,113 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009342 — — 10,810 individuals — European UK (+ Ireland) UKB —
PSS008224 — — 2,902 individuals — South Asian India (South Asia) UKB —