Trait: generalized anxiety disorder

Trait Information
Identifier MONDO_0001942
Description An anxiety disorder characterized by excessive and difficult-to-control worry about a number of life situations. The worry is accompanied by restlessness, fatigue, inability to concentrate, irritability, muscle tension, and/or sleep disturbance and lasts for at least 6 months. [NCIT: P378]
Trait category
Other trait
Synonym GAD

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018941
(TPMI_300.11_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Generalized anxiety disorder generalized anxiety disorder 729,735
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018941/ScoringFiles/PGS018941.txt.gz
PGS018942
(TPMI_300.11_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Generalized anxiety disorder generalized anxiety disorder 939,863
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018942/ScoringFiles/PGS018942.txt.gz
PGS018943
(TPMI_300.11_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Generalized anxiety disorder generalized anxiety disorder 21,630
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018943/ScoringFiles/PGS018943.txt.gz
PGS018944
(TPMI_300.11_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Generalized anxiety disorder generalized anxiety disorder 983,808
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018944/ScoringFiles/PGS018944.txt.gz
PGS018945
(TPMI_300.11_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Generalized anxiety disorder generalized anxiety disorder 975,855
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018945/ScoringFiles/PGS018945.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037123 PGS018941
(TPMI_300.11_Lassosum2)
 PSS012844|
East Asian Ancestry|
14,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Generalized anxiety disorder — AUROC: 0.59145 R²: 0.01052 sex, age, array, PCs 1-10 —
PPM037124 PGS018942
(TPMI_300.11_LDpred2)
 PSS012843|
East Asian Ancestry|
14,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Generalized anxiety disorder — AUROC: 0.5935 R²: 0.01111 sex, age, array, PCs 1-10 —
PPM037125 PGS018943
(TPMI_300.11_MegaPRS)
 PSS012845|
East Asian Ancestry|
14,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Generalized anxiety disorder — AUROC: 0.59612 R²: 0.01112 sex, age, array, PCs 1-10 —
PPM037126 PGS018944
(TPMI_300.11_PRS-CS)
 PSS012846|
East Asian Ancestry|
14,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Generalized anxiety disorder — AUROC: 0.59422 R²: 0.01116 sex, age, array, PCs 1-10 —
PPM037127 PGS018945
(TPMI_300.11_SBayesR)
 PSS012847|
East Asian Ancestry|
14,642 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Generalized anxiety disorder — AUROC: 0.59236 R²: 0.01101 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012843 300.02,F41.1 —
[
  • 454 cases
  • , 14,188 controls
]
,
46.82 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012844 300.02,F41.1 —
[
  • 454 cases
  • , 14,188 controls
]
,
46.82 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012845 300.02,F41.1 —
[
  • 454 cases
  • , 14,188 controls
]
,
46.82 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012846 300.02,F41.1 —
[
  • 454 cases
  • , 14,188 controls
]
,
46.82 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012847 300.02,F41.1 —
[
  • 454 cases
  • , 14,188 controls
]
,
46.82 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —