Trait: labyrinthitis

Trait Information
Identifier MONDO_0002008
Description Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [NCIT: C128369] [Wikipedia: Labyrinthitis]
Trait category
Other trait
Synonyms 3 synonyms
  • inflammation of internal ear
  • internal ear inflammation
  • otitis interna

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019096
(TPMI_386.3_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 245
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019096/ScoringFiles/PGS019096.txt.gz
PGS019097
(TPMI_386.3_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 939,831
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019097/ScoringFiles/PGS019097.txt.gz
PGS019098
(TPMI_386.3_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 14,820
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019098/ScoringFiles/PGS019098.txt.gz
PGS019099
(TPMI_386.3_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 983,780
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019099/ScoringFiles/PGS019099.txt.gz
PGS019100
(TPMI_386.3_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Labyrinthitis labyrinthitis 957,643
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019100/ScoringFiles/PGS019100.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037278 PGS019096
(TPMI_386.3_Lassosum2)
 PSS012999|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.57817 R²: 0.00841 sex, age, array, PCs 1-10 —
PPM037279 PGS019097
(TPMI_386.3_LDpred2)
 PSS012998|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58246 R²: 0.00937 sex, age, array, PCs 1-10 —
PPM037280 PGS019098
(TPMI_386.3_MegaPRS)
 PSS013000|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58134 R²: 0.0089 sex, age, array, PCs 1-10 —
PPM037281 PGS019099
(TPMI_386.3_PRS-CS)
 PSS013001|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.58388 R²: 0.00948 sex, age, array, PCs 1-10 —
PPM037282 PGS019100
(TPMI_386.3_SBayesR)
 PSS013002|
East Asian Ancestry|
17,995 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Labyrinthitis — AUROC: 0.57912 R²: 0.0088 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012998 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012999 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013000 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013001 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013002 386.3, 386.4, 386.5, 386.8,H81, H82, H83.0, H83.1, H83.2 —
[
  • 814 cases
  • , 17,181 controls
]
,
46.79 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —