Trait: facial nerve disorder

Trait Information
Identifier MONDO_0002098
Description A disease involving the facial nerve.
Trait category
Other trait
Synonyms 6 synonyms
  • disease of facial nerve
  • disease or disorder of facial nerve
  • disorder of facial nerve
  • facial nerve disease
  • facial nerve disease or disorder
  • facial nerve disorder

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018996
(TPMI_352.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Facial nerve disorders CN7 facial nerve disorder 241,782
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018996/ScoringFiles/PGS018996.txt.gz
PGS018997
(TPMI_352.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Facial nerve disorders CN7 facial nerve disorder 939,882
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018997/ScoringFiles/PGS018997.txt.gz
PGS018998
(TPMI_352.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Facial nerve disorders CN7 facial nerve disorder 18,580
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018998/ScoringFiles/PGS018998.txt.gz
PGS018999
(TPMI_352.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Facial nerve disorders CN7 facial nerve disorder 983,821
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018999/ScoringFiles/PGS018999.txt.gz
PGS019000
(TPMI_352.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Facial nerve disorders CN7 facial nerve disorder 1,002,253
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019000/ScoringFiles/PGS019000.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037178 PGS018996
(TPMI_352.2_Lassosum2)
 PSS012899|
East Asian Ancestry|
18,297 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Facial nerve disorders CN7 — AUROC: 0.67307 R²: 0.01135 sex, age, array, PCs 1-10 —
PPM037179 PGS018997
(TPMI_352.2_LDpred2)
 PSS012898|
East Asian Ancestry|
18,297 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Facial nerve disorders CN7 — AUROC: 0.67176 R²: 0.01121 sex, age, array, PCs 1-10 —
PPM037180 PGS018998
(TPMI_352.2_MegaPRS)
 PSS012900|
East Asian Ancestry|
18,297 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Facial nerve disorders CN7 — AUROC: 0.67501 R²: 0.01142 sex, age, array, PCs 1-10 —
PPM037181 PGS018999
(TPMI_352.2_PRS-CS)
 PSS012901|
East Asian Ancestry|
18,297 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Facial nerve disorders CN7 — AUROC: 0.67303 R²: 0.01128 sex, age, array, PCs 1-10 —
PPM037182 PGS019000
(TPMI_352.2_SBayesR)
 PSS012902|
East Asian Ancestry|
18,297 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Facial nerve disorders CN7 — AUROC: 0.67171 R²: 0.0112 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012898 351,G51 —
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012899 351,G51 —
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012900 351,G51 —
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012901 351,G51 —
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012902 351,G51 —
[
  • 178 cases
  • , 18,119 controls
]
,
46.77 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —