Trait: gingivitis

Trait Information
Identifier MONDO_0002508
Description A disorder involving inflammation of the gums; may affect surrounding and supporting structures of the teeth. [NCIT: C34636]
Trait category
Other trait
Synonyms 5 synonyms
  • acute gingivitis
  • chronic gingivitis
  • gingiva inflammation
  • gingivitis
  • inflammation of gingiva

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019305
(TPMI_523.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Gingivitis gingivitis 38,420
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019305/ScoringFiles/PGS019305.txt.gz
PGS019306
(TPMI_523.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Gingivitis gingivitis 939,855
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019306/ScoringFiles/PGS019306.txt.gz
PGS019307
(TPMI_523.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Gingivitis gingivitis 28,584
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019307/ScoringFiles/PGS019307.txt.gz
PGS019308
(TPMI_523.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Gingivitis gingivitis 983,793
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019308/ScoringFiles/PGS019308.txt.gz
PGS019309
(TPMI_523.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Gingivitis gingivitis 989,009
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019309/ScoringFiles/PGS019309.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037487 PGS019305
(TPMI_523.1_Lassosum2)
 PSS013203|
East Asian Ancestry|
17,094 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Gingivitis — AUROC: 0.709 R²: 0.0658 sex, age, array, PCs 1-10 —
PPM037488 PGS019306
(TPMI_523.1_LDpred2)
 PSS013202|
East Asian Ancestry|
17,094 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Gingivitis — AUROC: 0.70895 R²: 0.06566 sex, age, array, PCs 1-10 —
PPM037489 PGS019307
(TPMI_523.1_MegaPRS)
 PSS013204|
East Asian Ancestry|
17,094 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Gingivitis — AUROC: 0.70904 R²: 0.06565 sex, age, array, PCs 1-10 —
PPM037490 PGS019308
(TPMI_523.1_PRS-CS)
 PSS013205|
East Asian Ancestry|
17,094 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Gingivitis — AUROC: 0.70898 R²: 0.06564 sex, age, array, PCs 1-10 —
PPM037491 PGS019309
(TPMI_523.1_SBayesR)
 PSS013206|
East Asian Ancestry|
17,094 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Gingivitis — AUROC: 0.7094 R²: 0.06585 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013202 523.0, 523.1, 523.2,K05.0, K05.1, K06.0 —
[
  • 472 cases
  • , 16,622 controls
]
,
45.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013203 523.0, 523.1, 523.2,K05.0, K05.1, K06.0 —
[
  • 472 cases
  • , 16,622 controls
]
,
45.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013204 523.0, 523.1, 523.2,K05.0, K05.1, K06.0 —
[
  • 472 cases
  • , 16,622 controls
]
,
45.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013205 523.0, 523.1, 523.2,K05.0, K05.1, K06.0 —
[
  • 472 cases
  • , 16,622 controls
]
,
45.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013206 523.0, 523.1, 523.2,K05.0, K05.1, K06.0 —
[
  • 472 cases
  • , 16,622 controls
]
,
45.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —