Trait: keratitis

Trait Information
Identifier MONDO_0003085
Description A corneal disease that is characterized by inflammation of the cornea. [NCIT: C26805]
Trait category
Other trait
Synonyms 2 synonyms
  • cornea inflammation
  • inflammation of cornea

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019056
(TPMI_370_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 130,226
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019056/ScoringFiles/PGS019056.txt.gz
PGS019057
(TPMI_370_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 256,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019057/ScoringFiles/PGS019057.txt.gz
PGS019058
(TPMI_370_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 20,519
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019058/ScoringFiles/PGS019058.txt.gz
PGS019059
(TPMI_370_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 983,798
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019059/ScoringFiles/PGS019059.txt.gz
PGS019060
(TPMI_370_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Keratitis keratitis 983,726
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019060/ScoringFiles/PGS019060.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037238 PGS019056
(TPMI_370_Lassosum2)
 PSS012959|
East Asian Ancestry|
17,270 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Keratitis — AUROC: 0.6425 R²: 0.02353 sex, age, array, PCs 1-10 —
PPM037239 PGS019057
(TPMI_370_LDpred2)
 PSS012958|
East Asian Ancestry|
17,270 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Keratitis — AUROC: 0.64516 R²: 0.02464 sex, age, array, PCs 1-10 —
PPM037240 PGS019058
(TPMI_370_MegaPRS)
 PSS012960|
East Asian Ancestry|
17,270 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Keratitis — AUROC: 0.64239 R²: 0.02302 sex, age, array, PCs 1-10 —
PPM037241 PGS019059
(TPMI_370_PRS-CS)
 PSS012961|
East Asian Ancestry|
17,270 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Keratitis — AUROC: 0.64193 R²: 0.02342 sex, age, array, PCs 1-10 —
PPM037242 PGS019060
(TPMI_370_SBayesR)
 PSS012962|
East Asian Ancestry|
17,270 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Keratitis — AUROC: 0.64304 R²: 0.02348 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012958 370,B60.13, H16 —
[
  • 340 cases
  • , 16,930 controls
]
,
46.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012959 370,B60.13, H16 —
[
  • 340 cases
  • , 16,930 controls
]
,
46.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012960 370,B60.13, H16 —
[
  • 340 cases
  • , 16,930 controls
]
,
46.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012961 370,B60.13, H16 —
[
  • 340 cases
  • , 16,930 controls
]
,
46.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012962 370,B60.13, H16 —
[
  • 340 cases
  • , 16,930 controls
]
,
46.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —