Trait: tongue cancer

Trait Information
Identifier MONDO_0004631
Description A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. [NCIT: C9345]
Trait category
Other trait
Synonyms 50 synonyms
  • cancer of tongue
  • malignant neoplasm of anterior 2/3 of tongue
  • malignant neoplasm of anterior two-thirds of tongue
  • malignant neoplasm of anterior two-thirds of tongue, part unspecified
  • malignant neoplasm of base of tongue
  • malignant neoplasm of border of tongue
  • malignant neoplasm of dorsal surface of tongue
  • malignant neoplasm of dorsal tongue
  • malignant neoplasm of dorsal tongue NOS
  • malignant neoplasm of dorsum of tongue
  • malignant neoplasm of fixed part of tongue
  • malignant neoplasm of fixed part of tongue NOS
  • malignant neoplasm of junctional zone of tongue
  • malignant neoplasm of lingual tonsil
  • malignant neoplasm of mobile part of tongue
  • malignant neoplasm of mobile part of tongue NOS
  • malignant neoplasm of other sites of tongue
  • malignant neoplasm of the tongue
  • malignant neoplasm of tip and lateral border of tongue
  • malignant neoplasm of tip and/or lateral border of tongue
  • malignant neoplasm of tongue
  • malignant neoplasm of tongue NOS
  • malignant neoplasm of tongue, NOS
  • malignant neoplasm of tongue, tip and lateral border
  • malignant neoplasm of ventral surface of tongue
  • malignant neoplasm of ventral tongue surface
  • malignant tongue neoplasm
  • malignant tongue tumor
  • malignant tongue tumour
  • malignant tumor of anterior two-thirds of tongue
  • malignant tumor of base of tongue
  • malignant tumor of lingual tonsil
  • malignant tumor of lingual tonsil (disorder)
  • malignant tumor of mobile part of tongue
  • malignant tumor of posterior tongue
  • malignant tumor of the tongue
  • malignant tumor of tongue
  • malignant tumour of anterior two-thirds of tongue
  • malignant tumour of base of tongue
  • malignant tumour of lingual tonsil
  • malignant tumour of lingual tonsil (disorder)
  • malignant tumour of mobile part of tongue
  • malignant tumour of posterior tongue
  • malignant tumour of the tongue
  • malignant tumour of tongue
  • tongue cancer
  • tongue carcinoma
  • tongue neoplasm malignant
  • tongue neoplasm malignant stage unspecified
  • tongue neoplasm, malignant

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018460
(TPMI_145.2_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 11
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018460/ScoringFiles/PGS018460.txt.gz
PGS018461
(TPMI_145.2_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 34,059
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018461/ScoringFiles/PGS018461.txt.gz
PGS018462
(TPMI_145.2_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 570,182
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018462/ScoringFiles/PGS018462.txt.gz
PGS018463
(TPMI_145.2_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 983,776
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018463/ScoringFiles/PGS018463.txt.gz
PGS018464
(TPMI_145.2_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Tongue cancer tongue cancer 1,003,968
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018464/ScoringFiles/PGS018464.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036642 PGS018460
(TPMI_145.2_Lassosum2)
 PSS012358|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68616 R²: 0.01171 sex, age, array, PCs 1-10 —
PPM036643 PGS018461
(TPMI_145.2_LDpred2)
 PSS012357|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68599 R²: 0.01168 sex, age, array, PCs 1-10 —
PPM036644 PGS018462
(TPMI_145.2_MegaPRS)
 PSS012359|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68604 R²: 0.0117 sex, age, array, PCs 1-10 —
PPM036645 PGS018463
(TPMI_145.2_PRS-CS)
 PSS012360|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68622 R²: 0.0117 sex, age, array, PCs 1-10 —
PPM036646 PGS018464
(TPMI_145.2_SBayesR)
 PSS012361|
East Asian Ancestry|
19,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Cancer of tongue — AUROC: 0.68563 R²: 0.01173 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012357 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012358 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012359 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012360 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012361 141, V10.01,C01, C02, Z85.810 —
[
  • 201 cases
  • , 18,859 controls
]
,
45.19 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —