Trait: dermatophytosis

Trait Information
Identifier MONDO_0004678
Description A common fungal infection of the stratum corneum of the skin, hair, or nails by a dermatophyte. It is characterized by itching, inflammation, redness of the skin, small papular vesicles, central clearing, fissures, scaling, and/or hair loss in the affected area. [NCIT: P378]
Trait category
Other trait
Synonyms 6 synonyms
  • dermatomycosis
  • fungal skin disease
  • fungal skin diseases
  • ringworm
  • skin disease, fungal
  • skin diseases, fungal
Child trait(s) tinea unguium

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "dermatophytosis" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018445
(TPMI_110.11_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of nail tinea unguium 39,561
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018445/ScoringFiles/PGS018445.txt.gz
PGS018446
(TPMI_110.11_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of nail tinea unguium 350,151
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018446/ScoringFiles/PGS018446.txt.gz
PGS018447
(TPMI_110.11_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of nail tinea unguium 16,307
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018447/ScoringFiles/PGS018447.txt.gz
PGS018448
(TPMI_110.11_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of nail tinea unguium 983,814
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018448/ScoringFiles/PGS018448.txt.gz
PGS018449
(TPMI_110.11_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of nail tinea unguium 977,859
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018449/ScoringFiles/PGS018449.txt.gz
PGS018450
(TPMI_110.13_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 54
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018450/ScoringFiles/PGS018450.txt.gz
PGS018451
(TPMI_110.13_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 939,803
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018451/ScoringFiles/PGS018451.txt.gz
PGS018452
(TPMI_110.13_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 605,197
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018452/ScoringFiles/PGS018452.txt.gz
PGS018453
(TPMI_110.13_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 983,765
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018453/ScoringFiles/PGS018453.txt.gz
PGS018454
(TPMI_110.13_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Dermatophytosis of the body dermatophytosis 1,012,332
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018454/ScoringFiles/PGS018454.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036627 PGS018445
(TPMI_110.11_Lassosum2)
 PSS012348|
East Asian Ancestry|
18,675 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of nail — AUROC: 0.64442 R²: 0.03556 sex, age, array, PCs 1-10 —
PPM036628 PGS018446
(TPMI_110.11_LDpred2)
 PSS012347|
East Asian Ancestry|
18,675 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of nail — AUROC: 0.64093 R²: 0.03399 sex, age, array, PCs 1-10 —
PPM036629 PGS018447
(TPMI_110.11_MegaPRS)
 PSS012349|
East Asian Ancestry|
18,675 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of nail — AUROC: 0.63748 R²: 0.03245 sex, age, array, PCs 1-10 —
PPM036630 PGS018448
(TPMI_110.11_PRS-CS)
 PSS012350|
East Asian Ancestry|
18,675 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of nail — AUROC: 0.64402 R²: 0.03487 sex, age, array, PCs 1-10 —
PPM036631 PGS018449
(TPMI_110.11_SBayesR)
 PSS012351|
East Asian Ancestry|
18,675 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of nail — AUROC: 0.64206 R²: 0.03373 sex, age, array, PCs 1-10 —
PPM036632 PGS018450
(TPMI_110.13_Lassosum2)
 PSS012353|
East Asian Ancestry|
18,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of the body — AUROC: 0.66227 R²: 0.01587 sex, age, array, PCs 1-10 —
PPM036633 PGS018451
(TPMI_110.13_LDpred2)
 PSS012352|
East Asian Ancestry|
18,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of the body — AUROC: 0.66275 R²: 0.01528 sex, age, array, PCs 1-10 —
PPM036634 PGS018452
(TPMI_110.13_MegaPRS)
 PSS012354|
East Asian Ancestry|
18,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of the body — AUROC: 0.66222 R²: 0.01529 sex, age, array, PCs 1-10 —
PPM036635 PGS018453
(TPMI_110.13_PRS-CS)
 PSS012355|
East Asian Ancestry|
18,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of the body — AUROC: 0.66296 R²: 0.01529 sex, age, array, PCs 1-10 —
PPM036636 PGS018454
(TPMI_110.13_SBayesR)
 PSS012356|
East Asian Ancestry|
18,380 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Dermatophytosis of the body — AUROC: 0.66265 R²: 0.01527 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012349 110.1,B35.1 —
[
  • 519 cases
  • , 18,156 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012350 110.1,B35.1 —
[
  • 519 cases
  • , 18,156 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012351 110.1,B35.1 —
[
  • 519 cases
  • , 18,156 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012352 110.3, 110.5,B35.4, B35.5, B35.6 —
[
  • 224 cases
  • , 18,156 controls
]
,
45.83 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012353 110.3, 110.5,B35.4, B35.5, B35.6 —
[
  • 224 cases
  • , 18,156 controls
]
,
45.83 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012354 110.3, 110.5,B35.4, B35.5, B35.6 —
[
  • 224 cases
  • , 18,156 controls
]
,
45.83 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012355 110.3, 110.5,B35.4, B35.5, B35.6 —
[
  • 224 cases
  • , 18,156 controls
]
,
45.83 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012356 110.3, 110.5,B35.4, B35.5, B35.6 —
[
  • 224 cases
  • , 18,156 controls
]
,
45.83 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012347 110.1,B35.1 —
[
  • 519 cases
  • , 18,156 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012348 110.1,B35.1 —
[
  • 519 cases
  • , 18,156 controls
]
,
45.96 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —