Trait: pneumonia

Trait Information
Identifier MONDO_0005249
Description An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, caused by an infection in one or both of the lungs (by bacteria, viruses, fungi, or mycoplasma.). Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. [NCIT: P378]
Trait category
Other trait
Synonym acute pneumonia

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019280
(TPMI_480_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pneumonia pneumonia 144
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019280/ScoringFiles/PGS019280.txt.gz
PGS019281
(TPMI_480_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pneumonia pneumonia 149,980
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019281/ScoringFiles/PGS019281.txt.gz
PGS019282
(TPMI_480_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pneumonia pneumonia 517,334
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019282/ScoringFiles/PGS019282.txt.gz
PGS019283
(TPMI_480_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pneumonia pneumonia 983,820
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019283/ScoringFiles/PGS019283.txt.gz
PGS019284
(TPMI_480_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Pneumonia pneumonia 947,856
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019284/ScoringFiles/PGS019284.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037462 PGS019280
(TPMI_480_Lassosum2)
 PSS013183|
East Asian Ancestry|
18,873 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Pneumonia — AUROC: 0.61192 R²: 0.04685 sex, age, array, PCs 1-10 —
PPM037463 PGS019281
(TPMI_480_LDpred2)
 PSS013182|
East Asian Ancestry|
18,873 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Pneumonia — AUROC: 0.61184 R²: 0.04681 sex, age, array, PCs 1-10 —
PPM037464 PGS019282
(TPMI_480_MegaPRS)
 PSS013184|
East Asian Ancestry|
18,873 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Pneumonia — AUROC: 0.6121 R²: 0.04688 sex, age, array, PCs 1-10 —
PPM037465 PGS019283
(TPMI_480_PRS-CS)
 PSS013185|
East Asian Ancestry|
18,873 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Pneumonia — AUROC: 0.61189 R²: 0.0468 sex, age, array, PCs 1-10 —
PPM037466 PGS019284
(TPMI_480_SBayesR)
 PSS013186|
East Asian Ancestry|
18,873 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Pneumonia — AUROC: 0.61187 R²: 0.0469 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013182 003.22, 020.3, 020.4, 020.5, 021.2, 022.1, 031.0, 039.1, 052.1, 055.1, 073.0, 083.0, 112.4, 114.0, 114.4, 114.5, 130.4, 136.3, 480, 481, 482, 483, 484, 485, 486, 513, 517.1, V12.61,A02.22, A20.2, A21.2, A22.1, A31.0, A37.01, A37.11, A37.81, A37.91, A42.0, A43.0, A48.1, A75, A78, B01.2, B05.2, B25.0, B37.1, B38.0, B38.1, B38.2, B44.0, B58.3, B59, B77.81, J12, J13, J14, J15.0, J15.1, J15.2, J15.3, J15.4, J15.5, J15.6, J15.7, J15.8, J15.9, J16.0, J16.8, J17, J18, J85, Z87.01 —
[
  • 736 cases
  • , 18,137 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013183 003.22, 020.3, 020.4, 020.5, 021.2, 022.1, 031.0, 039.1, 052.1, 055.1, 073.0, 083.0, 112.4, 114.0, 114.4, 114.5, 130.4, 136.3, 480, 481, 482, 483, 484, 485, 486, 513, 517.1, V12.61,A02.22, A20.2, A21.2, A22.1, A31.0, A37.01, A37.11, A37.81, A37.91, A42.0, A43.0, A48.1, A75, A78, B01.2, B05.2, B25.0, B37.1, B38.0, B38.1, B38.2, B44.0, B58.3, B59, B77.81, J12, J13, J14, J15.0, J15.1, J15.2, J15.3, J15.4, J15.5, J15.6, J15.7, J15.8, J15.9, J16.0, J16.8, J17, J18, J85, Z87.01 —
[
  • 736 cases
  • , 18,137 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013184 003.22, 020.3, 020.4, 020.5, 021.2, 022.1, 031.0, 039.1, 052.1, 055.1, 073.0, 083.0, 112.4, 114.0, 114.4, 114.5, 130.4, 136.3, 480, 481, 482, 483, 484, 485, 486, 513, 517.1, V12.61,A02.22, A20.2, A21.2, A22.1, A31.0, A37.01, A37.11, A37.81, A37.91, A42.0, A43.0, A48.1, A75, A78, B01.2, B05.2, B25.0, B37.1, B38.0, B38.1, B38.2, B44.0, B58.3, B59, B77.81, J12, J13, J14, J15.0, J15.1, J15.2, J15.3, J15.4, J15.5, J15.6, J15.7, J15.8, J15.9, J16.0, J16.8, J17, J18, J85, Z87.01 —
[
  • 736 cases
  • , 18,137 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013185 003.22, 020.3, 020.4, 020.5, 021.2, 022.1, 031.0, 039.1, 052.1, 055.1, 073.0, 083.0, 112.4, 114.0, 114.4, 114.5, 130.4, 136.3, 480, 481, 482, 483, 484, 485, 486, 513, 517.1, V12.61,A02.22, A20.2, A21.2, A22.1, A31.0, A37.01, A37.11, A37.81, A37.91, A42.0, A43.0, A48.1, A75, A78, B01.2, B05.2, B25.0, B37.1, B38.0, B38.1, B38.2, B44.0, B58.3, B59, B77.81, J12, J13, J14, J15.0, J15.1, J15.2, J15.3, J15.4, J15.5, J15.6, J15.7, J15.8, J15.9, J16.0, J16.8, J17, J18, J85, Z87.01 —
[
  • 736 cases
  • , 18,137 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013186 003.22, 020.3, 020.4, 020.5, 021.2, 022.1, 031.0, 039.1, 052.1, 055.1, 073.0, 083.0, 112.4, 114.0, 114.4, 114.5, 130.4, 136.3, 480, 481, 482, 483, 484, 485, 486, 513, 517.1, V12.61,A02.22, A20.2, A21.2, A22.1, A31.0, A37.01, A37.11, A37.81, A37.91, A42.0, A43.0, A48.1, A75, A78, B01.2, B05.2, B25.0, B37.1, B38.0, B38.1, B38.2, B44.0, B58.3, B59, B77.81, J12, J13, J14, J15.0, J15.1, J15.2, J15.3, J15.4, J15.5, J15.6, J15.7, J15.8, J15.9, J16.0, J16.8, J17, J18, J85, Z87.01 —
[
  • 736 cases
  • , 18,137 controls
]
,
46.09 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —