Trait: hereditary nephritis

Trait Information
Identifier MONDO_0005334
Description A group of inherited conditions characterized initially by hematuria and slowly progressing to renal insufficiency. The most common form is the Alport syndrome (hereditary nephritis with hearing loss) which is caused by mutations in genes for type IV collagen and defective glomerular basement membrane. [EFO: 0004128]
Trait category
Other trait
Synonyms 3 synonyms
  • familial nephritis
  • hereditary nephritis
  • nephritis, familial
Child trait(s) IgA glomerulonephritis

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows PGS for child terms of "hereditary nephritis" in the EFO hierarchy.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS005282
(GRS15_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 15
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005282/ScoringFiles/PGS005282.txt.gz
PGS005283
(GRS21_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 21
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005283/ScoringFiles/PGS005283.txt.gz
PGS005284
(GRS55_nephropathy)
 PGP000756 |
Xu L et al. Phenomics (2024)
 IgA nephropathy IgA glomerulonephritis 55
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS005284/ScoringFiles/PGS005284.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022989 PGS005282
(GRS15_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.36 [1.3, 1.42] AUROC: 0.59 — — —
PPM022990 PGS005283
(GRS21_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —
PPM022991 PGS005284
(GRS55_nephropathy)
 PSS012087|
East Asian Ancestry|
12,207 individuals
 PGP000756 |
Xu L et al. Phenomics (2024)
 Reported Trait: IgA nephropathy OR: 1.62 [1.55, 1.69] AUROC: 0.63 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012087 — —
[
  • 3,365 cases
  • , 8,842 controls
]
 — East Asian
(Chinese)		 — NR PKU-IgAN Cohort