Trait: movement disorder

Trait Information
Identifier MONDO_0005395
Description Neurological conditions resulting in abnormal voluntary or involuntary movement, which may impact the speed, fluency, quality and ease of movement. [NCIT: C116757]
Trait category
Other trait
Synonyms 3 synonyms
  • movement disease
  • movement disorder
  • movement disorders

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018971
(TPMI_327.7_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sleep related movement disorders movement disorder 147,703
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018971/ScoringFiles/PGS018971.txt.gz
PGS018972
(TPMI_327.7_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sleep related movement disorders movement disorder 939,812
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018972/ScoringFiles/PGS018972.txt.gz
PGS018973
(TPMI_327.7_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sleep related movement disorders movement disorder 10,770
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018973/ScoringFiles/PGS018973.txt.gz
PGS018974
(TPMI_327.7_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sleep related movement disorders movement disorder 983,773
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018974/ScoringFiles/PGS018974.txt.gz
PGS018975
(TPMI_327.7_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Sleep related movement disorders movement disorder 1,002,797
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018975/ScoringFiles/PGS018975.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037153 PGS018971
(TPMI_327.7_Lassosum2)
 PSS012879|
East Asian Ancestry|
16,204 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sleep related movement disorders — AUROC: 0.59938 R²: 0.00228 sex, age, array, PCs 1-10 —
PPM037154 PGS018972
(TPMI_327.7_LDpred2)
 PSS012878|
East Asian Ancestry|
16,204 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sleep related movement disorders — AUROC: 0.59366 R²: 0.00218 sex, age, array, PCs 1-10 —
PPM037155 PGS018973
(TPMI_327.7_MegaPRS)
 PSS012880|
East Asian Ancestry|
16,204 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sleep related movement disorders — AUROC: 0.59286 R²: 0.00226 sex, age, array, PCs 1-10 —
PPM037156 PGS018974
(TPMI_327.7_PRS-CS)
 PSS012881|
East Asian Ancestry|
16,204 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sleep related movement disorders — AUROC: 0.59362 R²: 0.00215 sex, age, array, PCs 1-10 —
PPM037157 PGS018975
(TPMI_327.7_SBayesR)
 PSS012882|
East Asian Ancestry|
16,204 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Sleep related movement disorders — AUROC: 0.5943 R²: 0.00216 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012878 327.5, 333.94, 780.58,G25.81, G47.6 —
[
  • 128 cases
  • , 16,076 controls
]
,
47.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012879 327.5, 333.94, 780.58,G25.81, G47.6 —
[
  • 128 cases
  • , 16,076 controls
]
,
47.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012880 327.5, 333.94, 780.58,G25.81, G47.6 —
[
  • 128 cases
  • , 16,076 controls
]
,
47.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012881 327.5, 333.94, 780.58,G25.81, G47.6 —
[
  • 128 cases
  • , 16,076 controls
]
,
47.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012882 327.5, 333.94, 780.58,G25.81, G47.6 —
[
  • 128 cases
  • , 16,076 controls
]
,
47.11 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —