Trait: urticaria

Trait Information
Identifier MONDO_0005492
Description A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress. [MESH: D014581]
Trait category
Other trait
Synonyms 4 synonyms
  • Urticarias
  • hives
  • urticaria
  • urticaria (disease)

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019783
(TPMI_947_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urticaria urticaria 806,711
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019783/ScoringFiles/PGS019783.txt.gz
PGS019784
(TPMI_947_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urticaria urticaria 939,787
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019784/ScoringFiles/PGS019784.txt.gz
PGS019785
(TPMI_947_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urticaria urticaria 40,435
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019785/ScoringFiles/PGS019785.txt.gz
PGS019786
(TPMI_947_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urticaria urticaria 983,749
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019786/ScoringFiles/PGS019786.txt.gz
PGS019787
(TPMI_947_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Urticaria urticaria 973,975
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019787/ScoringFiles/PGS019787.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037965 PGS019783
(TPMI_947_Lassosum2)
 PSS013686|
East Asian Ancestry|
17,261 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Urticaria — AUROC: 0.6988 R²: 0.15105 sex, age, array, PCs 1-10 —
PPM037966 PGS019784
(TPMI_947_LDpred2)
 PSS013685|
East Asian Ancestry|
17,261 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Urticaria — AUROC: 0.70011 R²: 0.15277 sex, age, array, PCs 1-10 —
PPM037967 PGS019785
(TPMI_947_MegaPRS)
 PSS013687|
East Asian Ancestry|
17,261 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Urticaria — AUROC: 0.70174 R²: 0.15568 sex, age, array, PCs 1-10 —
PPM037968 PGS019786
(TPMI_947_PRS-CS)
 PSS013688|
East Asian Ancestry|
17,261 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Urticaria — AUROC: 0.69915 R²: 0.15139 sex, age, array, PCs 1-10 —
PPM037969 PGS019787
(TPMI_947_SBayesR)
 PSS013689|
East Asian Ancestry|
17,261 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Urticaria — AUROC: 0.6994 R²: 0.15197 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013685 708,D47.01, D89.4, L50 —
[
  • 671 cases
  • , 16,590 controls
]
,
46.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013686 708,D47.01, D89.4, L50 —
[
  • 671 cases
  • , 16,590 controls
]
,
46.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013687 708,D47.01, D89.4, L50 —
[
  • 671 cases
  • , 16,590 controls
]
,
46.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013688 708,D47.01, D89.4, L50 —
[
  • 671 cases
  • , 16,590 controls
]
,
46.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013689 708,D47.01, D89.4, L50 —
[
  • 671 cases
  • , 16,590 controls
]
,
46.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —