Trait: hydronephrosis

Trait Information
Identifier MONDO_0005510
Description Collection of urine in the renal pelvis that results in dilatation of the renal pelvis and calyces. It is caused by obstruction of urine flow, nephrolithiasis, or vesicoureteral reflux. Signs and symptoms include flank pain, nausea, vomiting, fever, and dysuria. [EFO: 0005562]
Trait category
Other trait

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019491
(TPMI_595_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 513,891
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019491/ScoringFiles/PGS019491.txt.gz
PGS019492
(TPMI_595_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 939,887
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019492/ScoringFiles/PGS019492.txt.gz
PGS019493
(TPMI_595_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 29,293
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019493/ScoringFiles/PGS019493.txt.gz
PGS019494
(TPMI_595_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 983,828
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019494/ScoringFiles/PGS019494.txt.gz
PGS019495
(TPMI_595_PRSmix+)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 1,070,950
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019495/ScoringFiles/PGS019495.txt.gz
PGS019496
(TPMI_595_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hydronephrosis hydronephrosis 998,183
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019496/ScoringFiles/PGS019496.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037673 PGS019491
(TPMI_595_Lassosum2)
 PSS013394|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.62497 R²: 0.01767 sex, age, array, PCs 1-10 —
PPM037674 PGS019492
(TPMI_595_LDpred2)
 PSS013393|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.6247 R²: 0.01687 sex, age, array, PCs 1-10 —
PPM037675 PGS019493
(TPMI_595_MegaPRS)
 PSS013395|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.62783 R²: 0.01688 sex, age, array, PCs 1-10 —
PPM037676 PGS019494
(TPMI_595_PRS-CS)
 PSS013396|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.62409 R²: 0.01727 sex, age, array, PCs 1-10 —
PPM037677 PGS019495
(TPMI_595_PRSmix+)
 PSS013397|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.64707 R²: 0.02172 sex, age, array, PCs 1-10 —
PPM037678 PGS019496
(TPMI_595_SBayesR)
 PSS013398|
East Asian Ancestry|
18,469 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hydronephrosis — AUROC: 0.6299 R²: 0.01741 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013393 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013394 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013395 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013396 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013397 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013398 591,N13.1, N13.2, N13.3 —
[
  • 392 cases
  • , 18,077 controls
]
,
44.75 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —