Trait: chronic rhinosinusitis

Trait Information
Identifier MONDO_0006031
Description Chronic form of sinusitis. [MONDO: patterns/chronic]
Trait category
Other trait
Synonyms 2 synonyms
  • chronic sinusitis
  • sinusitis, chronic

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019270
(TPMI_475_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic sinusitis chronic rhinosinusitis 16
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019270/ScoringFiles/PGS019270.txt.gz
PGS019271
(TPMI_475_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic sinusitis chronic rhinosinusitis 939,862
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019271/ScoringFiles/PGS019271.txt.gz
PGS019272
(TPMI_475_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic sinusitis chronic rhinosinusitis 15,628
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019272/ScoringFiles/PGS019272.txt.gz
PGS019273
(TPMI_475_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic sinusitis chronic rhinosinusitis 983,804
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019273/ScoringFiles/PGS019273.txt.gz
PGS019274
(TPMI_475_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic sinusitis chronic rhinosinusitis 968,351
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019274/ScoringFiles/PGS019274.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037452 PGS019270
(TPMI_475_Lassosum2)
 PSS013173|
East Asian Ancestry|
16,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic sinusitis — AUROC: 0.64256 R²: 0.04727 sex, age, array, PCs 1-10 —
PPM037453 PGS019271
(TPMI_475_LDpred2)
 PSS013172|
East Asian Ancestry|
16,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic sinusitis — AUROC: 0.6436 R²: 0.04727 sex, age, array, PCs 1-10 —
PPM037454 PGS019272
(TPMI_475_MegaPRS)
 PSS013174|
East Asian Ancestry|
16,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic sinusitis — AUROC: 0.63977 R²: 0.0454 sex, age, array, PCs 1-10 —
PPM037455 PGS019273
(TPMI_475_PRS-CS)
 PSS013175|
East Asian Ancestry|
16,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic sinusitis — AUROC: 0.64175 R²: 0.04626 sex, age, array, PCs 1-10 —
PPM037456 PGS019274
(TPMI_475_SBayesR)
 PSS013176|
East Asian Ancestry|
16,060 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic sinusitis — AUROC: 0.64071 R²: 0.0455 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013172 473, 784.91,J32, R09.82 —
[
  • 634 cases
  • , 15,426 controls
]
,
46.53 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013173 473, 784.91,J32, R09.82 —
[
  • 634 cases
  • , 15,426 controls
]
,
46.53 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013174 473, 784.91,J32, R09.82 —
[
  • 634 cases
  • , 15,426 controls
]
,
46.53 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013175 473, 784.91,J32, R09.82 —
[
  • 634 cases
  • , 15,426 controls
]
,
46.53 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013176 473, 784.91,J32, R09.82 —
[
  • 634 cases
  • , 15,426 controls
]
,
46.53 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —