Trait: Meniere disease

Trait Information
Identifier MONDO_0007972
Description A disease of the inner ear (labyrinth) that is characterized by fluctuating sensorineural hearing loss; tinnitus; episodic vertigo; and aural fullness. It is the most common form of endolymphatic hydrops. [MESH: D008575]
Trait category
Other trait
Synonym Meniere disease

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019086
(TPMI_386.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 802,789
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019086/ScoringFiles/PGS019086.txt.gz
PGS019087
(TPMI_386.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 939,888
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019087/ScoringFiles/PGS019087.txt.gz
PGS019088
(TPMI_386.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 23,220
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019088/ScoringFiles/PGS019088.txt.gz
PGS019089
(TPMI_386.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 983,823
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019089/ScoringFiles/PGS019089.txt.gz
PGS019090
(TPMI_386.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Menieres disease Meniere disease 987,552
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019090/ScoringFiles/PGS019090.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037268 PGS019086
(TPMI_386.1_Lassosum2)
 PSS012984|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61707 R²: 0.01248 sex, age, array, PCs 1-10 —
PPM037269 PGS019087
(TPMI_386.1_LDpred2)
 PSS012983|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61731 R²: 0.01262 sex, age, array, PCs 1-10 —
PPM037270 PGS019088
(TPMI_386.1_MegaPRS)
 PSS012985|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61749 R²: 0.01255 sex, age, array, PCs 1-10 —
PPM037271 PGS019089
(TPMI_386.1_PRS-CS)
 PSS012986|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61682 R²: 0.01254 sex, age, array, PCs 1-10 —
PPM037272 PGS019090
(TPMI_386.1_SBayesR)
 PSS012987|
East Asian Ancestry|
17,579 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Menieres disease — AUROC: 0.61747 R²: 0.01243 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012983 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012984 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012985 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012986 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012987 386.0,H81.0, H81.31, H81.39 —
[
  • 398 cases
  • , 17,181 controls
]
,
47.0 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —