Trait: acne

Trait Information
Identifier MONDO_0011438
Description An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin. [NCIT: P378]
Trait category
Other trait
Synonyms 5 synonyms
  • acne
  • acne (disease)
  • acne varioliformis
  • acne vulgaris
  • acne, adult

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS019634
(TPMI_706.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 565,294
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019634/ScoringFiles/PGS019634.txt.gz
PGS019635
(TPMI_706.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 273,955
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019635/ScoringFiles/PGS019635.txt.gz
PGS019636
(TPMI_706.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 17,458
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019636/ScoringFiles/PGS019636.txt.gz
PGS019637
(TPMI_706.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 983,822
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019637/ScoringFiles/PGS019637.txt.gz
PGS019638
(TPMI_706.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Acne acne 961,798
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019638/ScoringFiles/PGS019638.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM037816 PGS019634
(TPMI_706.1_Lassosum2)
 PSS013532|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76402 R²: 0.07598 sex, age, array, PCs 1-10 —
PPM037817 PGS019635
(TPMI_706.1_LDpred2)
 PSS013531|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76413 R²: 0.07611 sex, age, array, PCs 1-10 —
PPM037818 PGS019636
(TPMI_706.1_MegaPRS)
 PSS013533|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76454 R²: 0.07604 sex, age, array, PCs 1-10 —
PPM037819 PGS019637
(TPMI_706.1_PRS-CS)
 PSS013534|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.76392 R²: 0.07603 sex, age, array, PCs 1-10 —
PPM037820 PGS019638
(TPMI_706.1_SBayesR)
 PSS013535|
East Asian Ancestry|
19,142 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Acne — AUROC: 0.7639 R²: 0.07599 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS013533 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013534 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013535 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013531 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013532 706.0, 706.1,L70, L73.0 —
[
  • 233 cases
  • , 18,909 controls
]
,
45.93 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —