Trait: hyperlipidemia

Trait Information
Identifier MONDO_0021187
Trait category
Other trait
Synonyms 8 synonyms
  • hyperlipemia
  • hyperlipemias
  • hyperlipidemia
  • hyperlipidemia (disease)
  • lipemia
  • lipemias
  • lipidemia
  • lipidemias
Child trait(s) familial lipoprotein lipase deficiency

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "hyperlipidemia" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS018791
(TPMI_272.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 2,990
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018791/ScoringFiles/PGS018791.txt.gz
PGS018792
(TPMI_272.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 939,817
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018792/ScoringFiles/PGS018792.txt.gz
PGS018793
(TPMI_272.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 620,040
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018793/ScoringFiles/PGS018793.txt.gz
PGS018794
(TPMI_272.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 983,772
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018794/ScoringFiles/PGS018794.txt.gz
PGS018795
(TPMI_272.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperlipidemia hyperlipidemia 64,248
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018795/ScoringFiles/PGS018795.txt.gz
PGS018806
(TPMI_272.12_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperglyceridemia familial lipoprotein lipase deficiency 26
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018806/ScoringFiles/PGS018806.txt.gz
PGS018807
(TPMI_272.12_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperglyceridemia familial lipoprotein lipase deficiency 939,771
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018807/ScoringFiles/PGS018807.txt.gz
PGS018808
(TPMI_272.12_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperglyceridemia familial lipoprotein lipase deficiency 509,844
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018808/ScoringFiles/PGS018808.txt.gz
PGS018809
(TPMI_272.12_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperglyceridemia familial lipoprotein lipase deficiency 983,736
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018809/ScoringFiles/PGS018809.txt.gz
PGS018810
(TPMI_272.12_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Hyperglyceridemia familial lipoprotein lipase deficiency 26,876
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018810/ScoringFiles/PGS018810.txt.gz
PGS018811
(TPMI_272.13_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mixed hyperlipidemia hyperlipidemia 594
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018811/ScoringFiles/PGS018811.txt.gz
PGS018812
(TPMI_272.13_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mixed hyperlipidemia hyperlipidemia 939,841
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018812/ScoringFiles/PGS018812.txt.gz
PGS018813
(TPMI_272.13_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mixed hyperlipidemia hyperlipidemia 43,897
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018813/ScoringFiles/PGS018813.txt.gz
PGS018814
(TPMI_272.13_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mixed hyperlipidemia hyperlipidemia 983,790
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018814/ScoringFiles/PGS018814.txt.gz
PGS018815
(TPMI_272.13_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Mixed hyperlipidemia hyperlipidemia 62,199
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018815/ScoringFiles/PGS018815.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM036973 PGS018791
(TPMI_272.1_Lassosum2)
 PSS012704|
East Asian Ancestry|
19,320 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperlipidemia — AUROC: 0.60796 R²: 0.0461 sex, age, array, PCs 1-10 —
PPM036974 PGS018792
(TPMI_272.1_LDpred2)
 PSS012703|
East Asian Ancestry|
19,320 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperlipidemia — AUROC: 0.61052 R²: 0.04764 sex, age, array, PCs 1-10 —
PPM036975 PGS018793
(TPMI_272.1_MegaPRS)
 PSS012705|
East Asian Ancestry|
19,320 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperlipidemia — AUROC: 0.60094 R²: 0.04036 sex, age, array, PCs 1-10 —
PPM036976 PGS018794
(TPMI_272.1_PRS-CS)
 PSS012706|
East Asian Ancestry|
19,320 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperlipidemia — AUROC: 0.60973 R²: 0.04716 sex, age, array, PCs 1-10 —
PPM036977 PGS018795
(TPMI_272.1_SBayesR)
 PSS012707|
East Asian Ancestry|
19,320 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperlipidemia — AUROC: 0.60355 R²: 0.04274 sex, age, array, PCs 1-10 —
PPM036988 PGS018806
(TPMI_272.12_Lassosum2)
 PSS012694|
East Asian Ancestry|
12,025 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperglyceridemia — AUROC: 0.75986 R²: 0.03891 sex, age, array, PCs 1-10 —
PPM036989 PGS018807
(TPMI_272.12_LDpred2)
 PSS012693|
East Asian Ancestry|
12,025 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperglyceridemia — AUROC: 0.77316 R²: 0.04188 sex, age, array, PCs 1-10 —
PPM036990 PGS018808
(TPMI_272.12_MegaPRS)
 PSS012695|
East Asian Ancestry|
12,025 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperglyceridemia — AUROC: 0.73637 R²: 0.03131 sex, age, array, PCs 1-10 —
PPM036991 PGS018809
(TPMI_272.12_PRS-CS)
 PSS012696|
East Asian Ancestry|
12,025 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperglyceridemia — AUROC: 0.77433 R²: 0.04135 sex, age, array, PCs 1-10 —
PPM036992 PGS018810
(TPMI_272.12_SBayesR)
 PSS012697|
East Asian Ancestry|
12,025 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Hyperglyceridemia — AUROC: 0.76801 R²: 0.04021 sex, age, array, PCs 1-10 —
PPM036993 PGS018811
(TPMI_272.13_Lassosum2)
 PSS012699|
East Asian Ancestry|
14,526 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mixed hyperlipidemia — AUROC: 0.59356 R²: 0.02602 sex, age, array, PCs 1-10 —
PPM036994 PGS018812
(TPMI_272.13_LDpred2)
 PSS012698|
East Asian Ancestry|
14,526 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mixed hyperlipidemia — AUROC: 0.60037 R²: 0.02936 sex, age, array, PCs 1-10 —
PPM036995 PGS018813
(TPMI_272.13_MegaPRS)
 PSS012700|
East Asian Ancestry|
14,526 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mixed hyperlipidemia — AUROC: 0.58451 R²: 0.01996 sex, age, array, PCs 1-10 —
PPM036996 PGS018814
(TPMI_272.13_PRS-CS)
 PSS012701|
East Asian Ancestry|
14,526 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mixed hyperlipidemia — AUROC: 0.59628 R²: 0.02772 sex, age, array, PCs 1-10 —
PPM036997 PGS018815
(TPMI_272.13_SBayesR)
 PSS012702|
East Asian Ancestry|
14,526 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Mixed hyperlipidemia — AUROC: 0.59442 R²: 0.02653 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS012701 272.2,E78.2 —
[
  • 2,649 cases
  • , 11,877 controls
]
,
43.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012702 272.2,E78.2 —
[
  • 2,649 cases
  • , 11,877 controls
]
,
43.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012703 272.0, 272.1, 272.2, 272.3, 272.4,E78.0, E78.1, E78.2, E78.3, E78.4, E78.5 —
[
  • 7,443 cases
  • , 11,877 controls
]
,
45.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012704 272.0, 272.1, 272.2, 272.3, 272.4,E78.0, E78.1, E78.2, E78.3, E78.4, E78.5 —
[
  • 7,443 cases
  • , 11,877 controls
]
,
45.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012705 272.0, 272.1, 272.2, 272.3, 272.4,E78.0, E78.1, E78.2, E78.3, E78.4, E78.5 —
[
  • 7,443 cases
  • , 11,877 controls
]
,
45.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012706 272.0, 272.1, 272.2, 272.3, 272.4,E78.0, E78.1, E78.2, E78.3, E78.4, E78.5 —
[
  • 7,443 cases
  • , 11,877 controls
]
,
45.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012707 272.0, 272.1, 272.2, 272.3, 272.4,E78.0, E78.1, E78.2, E78.3, E78.4, E78.5 —
[
  • 7,443 cases
  • , 11,877 controls
]
,
45.95 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012693 272.1,E78.1 —
[
  • 148 cases
  • , 11,877 controls
]
,
42.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012694 272.1,E78.1 —
[
  • 148 cases
  • , 11,877 controls
]
,
42.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012695 272.1,E78.1 —
[
  • 148 cases
  • , 11,877 controls
]
,
42.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012696 272.1,E78.1 —
[
  • 148 cases
  • , 11,877 controls
]
,
42.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012697 272.1,E78.1 —
[
  • 148 cases
  • , 11,877 controls
]
,
42.51 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012698 272.2,E78.2 —
[
  • 2,649 cases
  • , 11,877 controls
]
,
43.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012699 272.2,E78.2 —
[
  • 2,649 cases
  • , 11,877 controls
]
,
43.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012700 272.2,E78.2 —
[
  • 2,649 cases
  • , 11,877 controls
]
,
43.54 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —