Trait: alcohol-related disorders

Trait Information
Identifier MONDO_0021698
Description Disorders related to or resulting from abuse or mis-use of alcohol. [MESH: D019973]
Trait category
Other trait
Synonyms 4 synonyms
  • alcohol related disorders
  • alcohol-related disorder
  • disorder, alcohol-related
  • disorders, alcohol-related
Child trait(s) 2 child traits

Associated Polygenic Score(s)

Filter PGS by Participant Ancestry
Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
Display options:
Ancestry legend
Multi-ancestry (including European)
Multi-ancestry (excluding European)
African
East Asian
South Asian
Additional Asian Ancestries
European
Greater Middle Eastern
Hispanic or Latin American
Additional Diverse Ancestries
Not Reported
Note: This table shows all PGS for "alcohol-related disorders" and any child terms of this trait in the EFO hierarchy by default.
Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000704
(HC171)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Alcoholic cirrhosis alcoholic liver cirrhosis 183,271
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000704/ScoringFiles/PGS000704.txt.gz - Check Terms/Licenses
PGS001777
(3-SNP_cirr)
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Cirrhosis (alcohol related) alcoholic liver cirrhosis 3
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS001777/ScoringFiles/PGS001777.txt.gz
PGS002738
(PRS_AUD)
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Alcohol use disorder alcohol dependence 326,000
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002738/ScoringFiles/PGS002738.txt.gz
PGS002739
(PRS_gene)
 PGP000346 |
Lai D et al. Transl Psychiatry (2022)
 Alcohol use disorder alcohol dependence 858
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS002739/ScoringFiles/PGS002739.txt.gz
PGS004913
(PRSALC)
 PGP000645 |
Schwantes-An TH et al. Hepatol Commun (2024)
 Alcohol-associated liver cirrhosis alcoholic liver cirrhosis 20
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS004913/ScoringFiles/PGS004913.txt.gz
PGS018956
(TPMI_317_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcohol related disorders alcohol-related disorders 30
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018956/ScoringFiles/PGS018956.txt.gz
PGS018957
(TPMI_317_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcohol related disorders alcohol-related disorders 939,840
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018957/ScoringFiles/PGS018957.txt.gz
PGS018958
(TPMI_317_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcohol related disorders alcohol-related disorders 22,608
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018958/ScoringFiles/PGS018958.txt.gz
PGS018959
(TPMI_317_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcohol related disorders alcohol-related disorders 983,786
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018959/ScoringFiles/PGS018959.txt.gz
PGS018960
(TPMI_317_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcohol related disorders alcohol-related disorders 913,261
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018960/ScoringFiles/PGS018960.txt.gz
PGS018961
(TPMI_317.1_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 15
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018961/ScoringFiles/PGS018961.txt.gz
PGS018962
(TPMI_317.1_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 939,838
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018962/ScoringFiles/PGS018962.txt.gz
PGS018963
(TPMI_317.1_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 25,361
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018963/ScoringFiles/PGS018963.txt.gz
PGS018964
(TPMI_317.1_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 983,785
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018964/ScoringFiles/PGS018964.txt.gz
PGS018965
(TPMI_317.1_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Alcoholism alcohol dependence 1,013,582
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS018965/ScoringFiles/PGS018965.txt.gz
PGS019355
(TPMI_571_Lassosum2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic liver disease and cirrhosis alcoholic liver cirrhosis 383
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019355/ScoringFiles/PGS019355.txt.gz
PGS019356
(TPMI_571_LDpred2)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic liver disease and cirrhosis alcoholic liver cirrhosis 939,833
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019356/ScoringFiles/PGS019356.txt.gz
PGS019357
(TPMI_571_MegaPRS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic liver disease and cirrhosis alcoholic liver cirrhosis 53,187
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019357/ScoringFiles/PGS019357.txt.gz
PGS019358
(TPMI_571_PRS-CS)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic liver disease and cirrhosis alcoholic liver cirrhosis 983,786
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019358/ScoringFiles/PGS019358.txt.gz
PGS019359
(TPMI_571_SBayesR)
 PGP000835 |
Chen HH et al. Nature (2025)
 Chronic liver disease and cirrhosis alcoholic liver cirrhosis 711,573
https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS019359/ScoringFiles/PGS019359.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001596 PGS000704
(HC171)
 PSS000792|
European Ancestry|
87,413 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Alcoholic cirrhosis — AUROC: 0.55471 — Age, sex, PCs(1-10) —
PPM001607 PGS000704
(HC171)
 PSS000793|
European Ancestry|
135,300 individuals
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Reported Trait: Alcoholic cirrhosis HR: 1.18 [1.11, 1.27] C-index: 0.711 — Age as time scale, sex, batch, PCs(1-10) —
PPM022382 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcohol-related cirrhosis HR: 1.67 [1.55, 1.8] — — sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array —
PPM022383 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcoholic hepatitis HR: 1.32 [1.12, 1.57] — — sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array —
PPM022384 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcohol-related cirrhosis x alcohol consumption interaction — — Hazard ratio (HR, heavy binge drinking and high PRS vs. below daily limit drinking and low PRS): 12.41 [4.96, 31.05] total weekly alcohol intake, diabetes, BMI, sex, age, ethnicity, Townsend deprivation index, physical activity, smoke, alcohol type, drinking with/without meals, genotyping array, and first 10 ancestry principal components —
PPM009254 PGS001777
(3-SNP_cirr)
 PSS007668|
European Ancestry|
1,766 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (females) β: 0.897 (0.172) AUROC: 0.635 (0.025) Odds Ratio (OR, top 20% vs bottom 20%): 3.81 [2.05, 7.07] — —
PPM009255 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (males) β: 0.8 (0.088) AUROC: 0.635 (0.016) Odds Ratio (OR, top 20% vs bottom 20%): 3.44 [2.48, 4.77] — —
PPM009256 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (females) — AUROC: 0.554 (0.036) Odds Ratio (OR, top 20% vs bottom 20%): 2.08 [1.11, 3.89] — —
PPM009247 PGS001777
(3-SNP_cirr)
 PSS007667|
European Ancestry|
1,390 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis β: 1.092 (0.099) AUROC: 0.665 (0.014) Odds Ratio (OR, top 20% vs bottom 20%): 5.99 [4.18, 8.6] — —
PPM009248 PGS001777
(3-SNP_cirr)
 PSS007668|
European Ancestry|
1,766 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis β: 0.669 (0.09) AUROC: 0.606 (0.014) Odds Ratio (OR, top 20% vs bottom 20%): 2.81 [2.03, 3.89] — —
PPM009249 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis β: 0.729 (0.08) AUROC: 0.619 (0.014) Odds Ratio (OR, top 20% vs bottom 20%): 3.1 [2.32, 4.14] — —
PPM009250 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis β: 0.748 (0.073) AUROC: 0.636 (0.015) Odds Ratio (OR, top 20% vs bottom 20%): 3.37 [2.38, 4.78] BMI, coffee —
PPM009251 PGS001777
(3-SNP_cirr)
 PSS007667|
European Ancestry|
1,390 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (males) β: 1.132 (0.116) AUROC: 0.671 (0.016) Odds Ratio (OR, top 20% vs bottom 20%): 6.18 [4.05, 9.41] — —
PPM009252 PGS001777
(3-SNP_cirr)
 PSS007667|
European Ancestry|
1,390 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (females) β: 0.974 (0.192) AUROC: 0.65 (0.027) Odds Ratio (OR, top 20% vs bottom 20%): 5.4 [2.67, 10.92] — —
PPM009253 PGS001777
(3-SNP_cirr)
 PSS007668|
European Ancestry|
1,766 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis (males) β: 0.575 (0.107) AUROC: 0.592 (0.017) Odds Ratio (OR, top 20% vs bottom 20%): 2.47 [1.68, 3.62] — —
PPM009257 PGS001777
(3-SNP_cirr)
 PSS007667|
European Ancestry|
1,390 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis in diabetics — — Odds Ratio (OR, high vs. low PRS): 5.32 [2.06, 13.7] — PRS Thresholds: Low (<= 0), High( >0.70)
PPM009258 PGS001777
(3-SNP_cirr)
 PSS007667|
European Ancestry|
1,390 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis in non-diabetics — — Odds Ratio (OR, high vs. low PRS): 4.77 [3.45, 6.58] — PRS Thresholds: Low (<= 0), High( >0.70)
PPM009259 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis in diabetics — — Odds Ratio (OR, high vs. low PRS): 3.74 [2.16, 6.48] — PRS Thresholds: Low (<= 0), High( >0.70)
PPM009260 PGS001777
(3-SNP_cirr)
 PSS007669|
European Ancestry|
6,898 individuals
 PGP000258 |
Whitfield JB et al. J Hepatol (2021)
 Reported Trait: Cirrhosis in non-diabetics — — Odds Ratio (OR, high vs. low PRS): 2.37 [1.86, 3.03] — PRS Thresholds: Low (<= 0), High( >0.70)
PPM014841 PGS002738
(PRS_AUD)
 PSS009911|
European Ancestry|
7,900 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder β: 3.17 (1.87) — Odds Ratio (OR top 10% vs rest): 1.96 [1.54, 2.51] — —
PPM014839 PGS002738
(PRS_AUD)
 PSS009910|
European Ancestry|
2,722 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with unknown family history of AUD β: 2.91 (0.38) — Odds Ratio (OR top 10% vs rest): 1.5 [0.98, 2.29] — —
PPM014838 PGS002738
(PRS_AUD)
 PSS009909|
European Ancestry|
4,842 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals with family history of AUD β: 2.43 (0.6) — Odds Ratio (OR top 10% vs rest): 1.86 [1.35, 2.56] — —
PPM014840 PGS002738
(PRS_AUD)
 PSS009908|
European Ancestry|
336 individuals
 PGP000345 |
Lai D et al. Alcohol Clin Exp Res (2022)
 Reported Trait: Alcohol use disorder (AUD) in individuals without family history of AUD β: 2.64 (0.47) — Odds Ratio (OR top 10% vs rest): 0.45 [0.12, 1.69] — —
PPM014842 PGS002739
(PRS_gene)
 PSS009912|
African Ancestry|
6,315 individuals
 PGP000346 |
Lai D et al. Transl Psychiatry (2022)
 Reported Trait: Alcohol use disorder β: 0.17 (0.03) — Odds Ratio (OR top 10% vs rest): 1.76 [1.32, 2.34] — —
PPM021374 PGS004913
(PRSALC)
 PSS011711|
European Ancestry|
9,448 individuals
 PGP000645 |
Schwantes-An TH et al. Hepatol Commun (2024)
 Reported Trait: Alcohol-associated liver cirrhosis — — R²: 0.02
Odds ratio (OR, top vs bottom PRS deciles): 2.75 [1.79, 4.21]		 Age, sex, 10 PCs —
PPM021375 PGS004913
(PRSALC)
 PSS011709|
European Ancestry|
3,360 individuals
 PGP000645 |
Schwantes-An TH et al. Hepatol Commun (2024)
 Reported Trait: Alcohol-associated liver cirrhosis — — R²: 0.029
Odds ratio (OR, top vs bottom PRS deciles): 4.4 [1.56, 12.44]		 Age, sex, 10 PCs —
PPM021376 PGS004913
(PRSALC)
 PSS011710|
European Ancestry|
3,709 individuals
 PGP000645 |
Schwantes-An TH et al. Hepatol Commun (2024)
 Reported Trait: Metabolic dysfunction-associated steatotic liver disease cirrhosis — — Odds ratio (OR, top vs bottom PRS deciles): 3.94 [2.23, 6.95] Age, sex, BMI, 10 PCs —
PPM037138 PGS018956
(TPMI_317_Lassosum2)
 PSS012864|
East Asian Ancestry|
19,532 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcohol related disorders — AUROC: 0.79513 R²: 0.04174 sex, age, array, PCs 1-10 —
PPM037139 PGS018957
(TPMI_317_LDpred2)
 PSS012863|
East Asian Ancestry|
19,532 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcohol related disorders — AUROC: 0.7961 R²: 0.04198 sex, age, array, PCs 1-10 —
PPM037140 PGS018958
(TPMI_317_MegaPRS)
 PSS012865|
East Asian Ancestry|
19,532 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcohol related disorders — AUROC: 0.78417 R²: 0.03795 sex, age, array, PCs 1-10 —
PPM037141 PGS018959
(TPMI_317_PRS-CS)
 PSS012866|
East Asian Ancestry|
19,532 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcohol related disorders — AUROC: 0.81339 R²: 0.04642 sex, age, array, PCs 1-10 —
PPM037142 PGS018960
(TPMI_317_SBayesR)
 PSS012867|
East Asian Ancestry|
19,532 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcohol related disorders — AUROC: 0.79729 R²: 0.04209 sex, age, array, PCs 1-10 —
PPM037143 PGS018961
(TPMI_317.1_Lassosum2)
 PSS012859|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79678 R²: 0.03346 sex, age, array, PCs 1-10 —
PPM037144 PGS018962
(TPMI_317.1_LDpred2)
 PSS012858|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79624 R²: 0.03318 sex, age, array, PCs 1-10 —
PPM037145 PGS018963
(TPMI_317.1_MegaPRS)
 PSS012860|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.78241 R²: 0.02968 sex, age, array, PCs 1-10 —
PPM037146 PGS018964
(TPMI_317.1_PRS-CS)
 PSS012861|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.81585 R²: 0.03723 sex, age, array, PCs 1-10 —
PPM037147 PGS018965
(TPMI_317.1_SBayesR)
 PSS012862|
East Asian Ancestry|
19,503 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Alcoholism — AUROC: 0.79751 R²: 0.03342 sex, age, array, PCs 1-10 —
PPM037537 PGS019355
(TPMI_571_Lassosum2)
 PSS013268|
East Asian Ancestry|
18,730 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic liver disease and cirrhosis — AUROC: 0.64281 R²: 0.06977 sex, age, array, PCs 1-10 —
PPM037538 PGS019356
(TPMI_571_LDpred2)
 PSS013267|
East Asian Ancestry|
18,730 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic liver disease and cirrhosis — AUROC: 0.64424 R²: 0.07074 sex, age, array, PCs 1-10 —
PPM037539 PGS019357
(TPMI_571_MegaPRS)
 PSS013269|
East Asian Ancestry|
18,730 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic liver disease and cirrhosis — AUROC: 0.63961 R²: 0.06771 sex, age, array, PCs 1-10 —
PPM037540 PGS019358
(TPMI_571_PRS-CS)
 PSS013270|
East Asian Ancestry|
18,730 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic liver disease and cirrhosis — AUROC: 0.64417 R²: 0.07095 sex, age, array, PCs 1-10 —
PPM037541 PGS019359
(TPMI_571_SBayesR)
 PSS013271|
East Asian Ancestry|
18,730 individuals
 PGP000835 |
Chen HH et al. Nature (2025)
 Reported Trait: Chronic liver disease and cirrhosis — AUROC: 0.64095 R²: 0.0684 sex, age, array, PCs 1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011933 — — 294,816 individuals — European — UKB —
PSS011933 — — 17,783 individuals — Not reported — UKB —
PSS011709 — —
[
  • 121 cases
  • , 3,239 controls
]
 — European — IB-liver —
PSS011710 — —
[
  • 470 cases
  • , 3,239 controls
]
 — European — IB-liver —
PSS011711 Cirrhosis cases were defined as having ICD10 code K70.3; “alcohol-associated cirrhosis of liver', or ICD-9 code 571.2, “Cirrhosis, liver, alcohol-associated or ICD10 code K70.1; “alcoholic hepatitis without ascites” or ICD-9 code 571.1, “acute alcoholic hepatitis.” Controls were defined as having (1) reported alcohol intake of ≥80 g/d (males) and ≥50 g/d (females) and/or (2) ICD10 diagnosis of F10.2 (mental and behavioral disorders due to alcohol) but with no recorded diagnosis of any liver disease as defined previously —
[
  • 467 cases
  • , 8,981 controls
]
 — European — UKB —
PSS012858 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012859 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012860 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012861 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012862 291.1, 291.2, 291.3, 291.81, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, V11.3,F10.1, F10.230, F10.232, F10.239, F10.251, F10.26, F10.27, F10.951, F10.96, F10.97, G62.1, K29.2, K70 —
[
  • 156 cases
  • , 19,347 controls
]
,
45.18 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012863 291, 303, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, 790.3, 980.0, E860.0, E860.1, V11.3,F10, G62.1, K29.2, K70, R78.0 —
[
  • 185 cases
  • , 19,347 controls
]
,
45.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012864 291, 303, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, 790.3, 980.0, E860.0, E860.1, V11.3,F10, G62.1, K29.2, K70, R78.0 —
[
  • 185 cases
  • , 19,347 controls
]
,
45.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012865 291, 303, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, 790.3, 980.0, E860.0, E860.1, V11.3,F10, G62.1, K29.2, K70, R78.0 —
[
  • 185 cases
  • , 19,347 controls
]
,
45.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012866 291, 303, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, 790.3, 980.0, E860.0, E860.1, V11.3,F10, G62.1, K29.2, K70, R78.0 —
[
  • 185 cases
  • , 19,347 controls
]
,
45.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS012867 291, 303, 305.0, 357.5, 535.3, 571.0, 571.1, 571.2, 571.3, 790.3, 980.0, E860.0, E860.1, V11.3,F10, G62.1, K29.2, K70, R78.0 —
[
  • 185 cases
  • , 19,347 controls
]
,
45.23 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS007667 — —
[
  • 917 cases
  • , 473 controls
]
,
72.3 % Male samples
 — European — GenomALC —
PSS007668 — —
[
  • 1,162 cases
  • , 604 controls
]
,
62.06 % Male samples
 — European — GenomALC —
PSS007669 — —
[
  • 594 cases
  • , 6,304 controls
]
,
77.02 % Male samples
 — European — UKB —
PSS013267 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 —
[
  • 3,031 cases
  • , 15,699 controls
]
,
45.81 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013268 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 —
[
  • 3,031 cases
  • , 15,699 controls
]
,
45.81 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013269 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 —
[
  • 3,031 cases
  • , 15,699 controls
]
,
45.81 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013270 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 —
[
  • 3,031 cases
  • , 15,699 controls
]
,
45.81 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS013271 571, 572,K70.4, K71.11, K72, K74.0, K74.1, K74.2, K74.3, K74.4, K74.5, K74.6, K75.0, K75.1, K75.81, K76.0, K76.6, K76.7, K76.8 —
[
  • 3,031 cases
  • , 15,699 controls
]
,
45.81 % Male samples
 — East Asian
(Han Chinese)		 — TPMI —
PSS000792 — — 87,413 individuals — European — UKB —
PSS000793 ICD-10 K70 —
[
  • 845 cases
  • , 134,455 controls
]
 — European
(Finnish)		 — FinnGen —
PSS009908 — —
[
  • 72 cases
  • , 107 controls
]
 — European — COGA —
PSS009909 — —
[
  • 2,531 cases
  • , 669 controls
]
 — European — COGA —
PSS009910 — —
[
  • 850 cases
  • , 840 controls
]
 — European — COGA —
PSS009911 — —
[
  • 3,451 cases
  • , 1,616 controls
]
,
48.0 % Male samples
 — European — COGA —
PSS009912 — —
[
  • 2,786 cases
  • , 3,529 controls
]
 — African American or Afro-Caribbean — COGA, SAGE, Yale-Penn —